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公开(公告)号：US20100041051A1
公开(公告)日：2010-02-18
申请号：US12536326
申请日：2009-08-05
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/16
摘要： An assay for diagnosing or prognosticating prostate cancer incorporates the detection of hypermethylation of SEQ ID NO 1, SEQ ID NO 3, and SEQ ID NO 2 genes and may be incorporated into a nomogram.
摘要翻译： 用于诊断或预测前列腺癌的测定法包括检测SEQ ID NO 1，SEQ ID NO 3和SEQ ID NO 2基因的高甲基化，并且可以并入到诺欧图中。
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公开(公告)号：US20090186360A1
公开(公告)日：2009-07-23
申请号：US12355869
申请日：2009-01-19
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/16
摘要： An assay for detecting prostate cancer includes reagents for detecting multiple methylation markers from within one gene such as GSTP1.
摘要翻译： 用于检测前列腺癌的测定法包括用于从一个基因（例如GSTP1）内检测多个甲基化标记物的试剂。
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公开(公告)号：US20090047656A1
公开(公告)日：2009-02-19
申请号：US11717835
申请日：2007-03-13
申请人： Jonathan F. Baden , Chang H. Choi , Dondapati Chowdary , Kathleen M. Curtin , Tatiana Vener , Haiying Wang , Christine A. Burnett , Abhijit Mazumder
发明人： Jonathan F. Baden , Chang H. Choi , Dondapati Chowdary , Kathleen M. Curtin , Tatiana Vener , Haiying Wang , Christine A. Burnett , Abhijit Mazumder
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16 , C12Q2600/178
摘要： The present invention provides a method of propagating cells of interest obtained from a biological specimen by a) enriching the cells under conditions that maintain sufficient cell viability; and b) propagating the cells under conditions effective to allow cell viability, proliferation and integrity.
摘要翻译： 本发明提供一种通过以下步骤来繁殖生物样品获得的感兴趣的细胞：（a）在维持足够细胞活力的条件下使细胞富集; 和b）在有效允许细胞活力，增殖和完整性的条件下繁殖细胞。
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4.发明申请Methods and Materials for Identifying the Origin of a Carcinoma of Unknown Primary Origin 审中-公开识别原发性原发性癌的原因的方法和材料公开(公告)号：US20100021886A1
公开(公告)日：2010-01-28
申请号：US12024134
申请日：2008-02-01
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into a linear discrimination analysis where the linear discrimination analysis normalizes the Biomarkers against a reference; and imposes a cut-off which optimizes sensitivity and specificity of each Biomarker, weights the prevalence of the carcinomas and selects a tissue of origin determining origin based on highest probability determined by the linear discrimination analysis or determining that the carcinoma is not derived from a particular set of carcinomas; and optionally measuring Biomarkers specific for one or more additional different carcinoma, and repeating the steps for additional Biomarkers.
摘要翻译： 本发明提供了通过获得含有转移细胞的样品来鉴定未知来源的转移起点的方法; 测量与至少两种不同癌相关的生物标志物; 将来自生物标志物的数据组合成线性鉴别分析，其中线性鉴别分析使生物标志物反对参考标准化; 并强加了一个优化每个生物标志物的灵敏度和特异性的切断点，重视癌症的流行，并且基于通过线性鉴别分析确定的最高概率来选择确定起源的组织，或者确定癌症不是从特定的 一套癌; 并且任选地测量对一种或多种另外的不同癌特异性的生物标志物，并重复其它生物标志物的步骤。
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公开(公告)号：US20100081145A1
公开(公告)日：2010-04-01
申请号：US12628764
申请日：2009-12-01
IPC分类号： C12Q1/68
CPC分类号： G01N33/57434 , G01N2333/91171
摘要： Methods and kits for detecting prostate cancer in urine samples include detecting the methylation status of various genes.
摘要翻译： 用于检测尿样中前列腺癌的方法和试剂盒包括检测各种基因的甲基化状态。
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公开(公告)号：US20080254455A1
公开(公告)日：2008-10-16
申请号：US11734763
申请日：2007-04-12
CPC分类号： G01N33/57434 , G01N2333/91171
摘要： Methods and kits for detecting prostate cancer in urine samples include detecting the methylation status of various genes.
摘要翻译： 用于检测尿样中前列腺癌的方法和试剂盒包括检测各种基因的甲基化状态。
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公开(公告)号：US20080213781A1
公开(公告)日：2008-09-04
申请号：US12032085
申请日：2008-02-15
申请人： Jonathan F. Baden , Jennifer Painter , Shobha A. Varde , Jyoti Mehrotra , Tatiana I. Vener , Abhijit Mazumder
发明人： Jonathan F. Baden , Jennifer Painter , Shobha A. Varde , Jyoti Mehrotra , Tatiana I. Vener , Abhijit Mazumder
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2523/125 , C12Q2600/154 , C12Q2600/16
摘要： A method of increasing sensitivity of a DNA methylation assay by determining complementation within a CpG island of the methylated DNA.
摘要翻译： 通过测定甲基化DNA的CpG岛内的互补来提高DNA甲基化测定的灵敏度的方法。
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