公开(公告)号：US08841287B2

公开(公告)日：2014-09-23

申请号：US12997567

申请日：2009-06-11

Applicant: Hui Cai ,  Frank Chavez ,  Paul J. Dunford ,  Andrew J. Greenspan ,  Steven P. Meduna ,  Jorge A. Quiroz ,  Brad M. Savall ,  Kevin L. Tays ,  Robin L. Thurmond ,  Jianmei Wei ,  Ronald L. Wolin ,  Xiaohu Zhang

Inventor： Hui Cai ,  Frank Chavez ,  Paul J. Dunford ,  Andrew J. Greenspan ,  Steven P. Meduna ,  Jorge A. Quiroz ,  Brad M. Savall ,  Kevin L. Tays ,  Robin L. Thurmond ,  Jianmei Wei ,  Ronald L. Wolin ,  Xiaohu Zhang

IPC: A01N43/00

CPC classification number: C07D213/74 ,  A61K31/44 ,  A61K31/50 ,  C07D237/20 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14 ,  C07D487/04

Abstract: Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Abstract translation: 可用作H 4受体调节剂的二氨基 - 吡啶，嘧啶和哒嗪化合物，以及用于治疗H4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和 瘙痒症

公开(公告)号：US20110092474A1

公开(公告)日：2011-04-21

申请号：US12997567

申请日：2009-06-11

Applicant: Hui Cai ,  Frank Chavez ,  Paul J. Dunford ,  Andrew J. Greenspan ,  Steven P. Meduna ,  Jorge A. Quiroz ,  Brad M. Savall ,  Kevin L. Tays ,  Robin L. Thurmond ,  Jianmei Wei ,  Ronald L. Wolin ,  Xiaohu Zhang

Inventor： Hui Cai ,  Frank Chavez ,  Paul J. Dunford ,  Andrew J. Greenspan ,  Steven P. Meduna ,  Jorge A. Quiroz ,  Brad M. Savall ,  Kevin L. Tays ,  Robin L. Thurmond ,  Jianmei Wei ,  Ronald L. Wolin ,  Xiaohu Zhang

IPC: A61K31/4439 ,  C07D401/04 ,  C07D405/14 ,  A61K31/496 ,  C07D403/04 ,  A61K31/506 ,  C07D401/14 ,  A61K31/501 ,  C07D487/04 ,  A61K31/551 ,  A61K31/444 ,  C07D237/20 ,  A61K31/50 ,  A61P29/00 ,  A61P37/08 ,  A61P17/00 ,  A61P37/06 ,  A61P37/04 ,  A61P11/06 ,  A61P9/10 ,  A61P25/00 ,  A61P27/02 ,  A61P1/00 ,  A61P17/06 ,  A61P17/04 ,  A61P11/00 ,  A61P3/10 ,  A61P13/12 ,  A61P7/06 ,  A61P1/16 ,  A61P25/24 ,  A61P25/18 ,  A61P25/22 ,  A61P25/04

CPC classification number: C07D213/74 ,  A61K31/44 ,  A61K31/50 ,  C07D237/20 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14 ,  C07D487/04

Abstract: Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Abstract translation: 可用作H 4受体调节剂的二氨基 - 吡啶，嘧啶和哒嗪化合物，以及用于治疗H4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和 瘙痒症