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1.发明授权Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor 有权二氨基 - 吡啶，嘧啶和组胺H4受体的哒嗪调节剂公开(公告)号：US08841287B2
公开(公告)日：2014-09-23
申请号：US12997567
申请日：2009-06-11
Applicant: Hui Cai , Frank Chavez , Paul J. Dunford , Andrew J. Greenspan , Steven P. Meduna , Jorge A. Quiroz , Brad M. Savall , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei , Ronald L. Wolin , Xiaohu Zhang
Inventor： Hui Cai , Frank Chavez , Paul J. Dunford , Andrew J. Greenspan , Steven P. Meduna , Jorge A. Quiroz , Brad M. Savall , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei , Ronald L. Wolin , Xiaohu Zhang
IPC: A01N43/00
CPC classification number: C07D213/74 , A61K31/44 , A61K31/50 , C07D237/20 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D487/04
Abstract: Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Abstract translation: 可用作H 4受体调节剂的二氨基 - 吡啶，嘧啶和哒嗪化合物，以及用于治疗H4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和 瘙痒症
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2.发明授权Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor 有权组胺H4受体的苯并呋喃和苯并噻吩并嘧啶调节剂公开(公告)号：US08030321B2
公开(公告)日：2011-10-04
申请号：US12496932
申请日：2009-07-02
Applicant: Frank Chavez , Michael P. Curtis , James P. Edwards , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Brad M. Savall
Inventor： Frank Chavez , Michael P. Curtis , James P. Edwards , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Brad M. Savall
IPC: A01N43/54 , A61K31/505 , C07D239/00 , C07D471/00 , C07D491/00
CPC classification number: C07D491/048 , C07D491/147 , C07D495/04 , C07D519/00
Abstract: Benzofuro- and benzothienopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Abstract translation: 描述了苯并呋喃和苯并噻吩并嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于治疗由H 4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和瘙痒症。
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公开(公告)号：US20110166132A1
公开(公告)日：2011-07-07
申请号：US12746902
申请日：2008-12-12
Applicant: Stephen A. Hitchcock , Jian J. Chen , Mqhele Vellah Ncube , Thomas Nixey , Albert Amegadzie , Roxanne Kunz , Wenyan Qian , Ning Chen , Christopher M. Tegley , Frenel F. De Morin , Chester Chenguang Yuan , Qingyian Liu , Jiawang Zhu , Tanya A.N. Peterkin , Jeffrey A. Adams , Essa Hu , Frank Chavez, JR.
Inventor： Stephen A. Hitchcock , Jian J. Chen , Mqhele Vellah Ncube , Thomas Nixey , Albert Amegadzie , Roxanne Kunz , Wenyan Qian , Ning Chen , Christopher M. Tegley , Frenel F. De Morin , Chester Chenguang Yuan , Qingyian Liu , Jiawang Zhu , Tanya A.N. Peterkin , Jeffrey A. Adams , Essa Hu , Frank Chavez, JR.
IPC: A61K31/538 , C07D213/56 , C07D413/12 , C07D401/12 , C07D401/14 , C07D413/14 , C07D405/12 , C07D233/61 , C07D403/12 , A61K31/4418 , A61K31/4439 , A61K31/496 , A61K31/444 , A61K31/4725 , A61K31/4545 , A61K31/5377 , A61K31/4433 , A61K31/4709 , A61K31/4164 , A61K31/4178 , A61P25/28
CPC classification number: C07D213/40 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12
Abstract: The present invention provides compounds that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
Abstract translation: 本发明提供了γ-分泌酶调节剂的化合物，因此可用于治疗通过调节γ分泌酶如阿尔茨海默病可治疗的疾病。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。
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公开(公告)号：US20080194577A1
公开(公告)日：2008-08-14
申请号：US12070051
申请日：2008-02-14
Applicant: Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
Inventor： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
IPC: A61K31/496 , C07D239/48 , A61K31/505 , A61P37/08 , C07K14/705 , A61P17/00 , A61P29/00 , C07D403/04
CPC classification number: C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Abstract translation: 描述了2-氨基嘧啶化合物，其可用作H 4 S 5受体调节剂。 这样的化合物可以用于治疗由H 4 S受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫疾病和瘙痒症。
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5.发明申请公开(公告)号：US20130079325A1
公开(公告)日：2013-03-28
申请号：US13676826
申请日：2012-11-14
Applicant: Jennifer R. Allen , Biswas Kaustav , Frank Chavez , Ning Chen , Frenel Fils De Morin , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Roxanne Kunz , Holger Monenschein , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Guomin Yao
Inventor： Jennifer R. Allen , Biswas Kaustav , Frank Chavez , Ning Chen , Frenel Fils De Morin , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Roxanne Kunz , Holger Monenschein , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Guomin Yao
IPC: C07D413/14 , C07D401/14 , C07D401/12
CPC classification number: C07D413/14 , C07D401/12 , C07D401/14 , C07D417/12 , C07D471/04 , C07D473/00
Abstract: Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
Abstract translation: 吡啶和嘧啶化合物，以及含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症等。
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Patent Agency Ranking
公开(公告)号：US20090325927A1
公开(公告)日：2009-12-31
申请号：US12496932
申请日：2009-07-02
Applicant: Frank Chavez , Michael P. Curtis , James P. Edwards , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Brad M. Savall
Inventor： Frank Chavez , Michael P. Curtis , James P. Edwards , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Brad M. Savall
IPC: A61K31/496 , C07D491/048 , C07D405/14 , A61K31/551 , A61K31/397 , A61P37/00
CPC classification number: C07D491/048 , C07D491/147 , C07D495/04 , C07D519/00
Abstract: Benzofuro- and benzothienopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
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公开(公告)号：US20110160451A1
公开(公告)日：2011-06-30
申请号：US13043391
申请日：2011-03-08
Applicant: Hui CAI , Frank CHAVEZ , James P. EDWARDS , Anne E. FITZGERALD , Jing LIU , Neelakandha S. MANI , Danielle K. NEFF , Michele C. RIZZOLIO , Brad M. SAVALL , Deborah M. SMITH , Jennifer D. VENABLE , Jianmei WEI , Ronald L. WOLIN
Inventor： Hui CAI , Frank CHAVEZ , James P. EDWARDS , Anne E. FITZGERALD , Jing LIU , Neelakandha S. MANI , Danielle K. NEFF , Michele C. RIZZOLIO , Brad M. SAVALL , Deborah M. SMITH , Jennifer D. VENABLE , Jianmei WEI , Ronald L. WOLIN
IPC: C07D403/04 , C07D401/04 , C07D487/04 , C07D471/04 , C07D487/08 , C07D405/14 , C07D487/10 , C07D498/04 , C07D491/052 , C07D239/48 , C07D409/14 , C07D409/06
CPC classification number: C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Abstract translation: 描述了2-氨基嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于治疗由H 4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和瘙痒症。
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8.发明申请公开(公告)号：US20100125062A1
公开(公告)日：2010-05-20
申请号：US12619573
申请日：2009-11-16
Applicant: Jennifer R. Allen , Kaustav Biswas , Frank Chavez, Jr. , Ning Chen , Frenel Fils Demorin , James R. Falsey , Mike Frohn , Paul Harrington , Dan Horne , Essa Hu , Matthew R. Kaller , Roxanne Kunz , Holger Monenschein , Tom Nguyen , Alex Pickrell , Andreas Reichelt , Shannon Rumfelt , Rob Rzasa , Kelvin Sham , Guomin Yao
Inventor： Jennifer R. Allen , Kaustav Biswas , Frank Chavez, Jr. , Ning Chen , Frenel Fils Demorin , James R. Falsey , Mike Frohn , Paul Harrington , Dan Horne , Essa Hu , Matthew R. Kaller , Roxanne Kunz , Holger Monenschein , Tom Nguyen , Alex Pickrell , Andreas Reichelt , Shannon Rumfelt , Rob Rzasa , Kelvin Sham , Guomin Yao
IPC: A61K31/4439 , C07D401/12 , C07D471/04 , C07D473/00 , C07D413/14 , C07D401/14 , A61K31/437 , A61K31/52 , A61K31/5377 , A61K31/55 , A61K31/397 , A61P25/00
CPC classification number: C07D413/14 , C07D401/12 , C07D401/14 , C07D417/12 , C07D471/04 , C07D473/00
Abstract: Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
Abstract translation: 吡啶和嘧啶化合物，以及含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖型糖尿病，精神分裂症，双相情感障碍，强迫症等。
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9.发明授权Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor 有权组胺H4受体的苯并呋喃和苯并噻吩并嘧啶调节剂公开(公告)号：US07576092B2
公开(公告)日：2009-08-18
申请号：US11827354
申请日：2007-07-10
Applicant: Frank Chavez , Michael P. Curtis , James P. Edwards , Anne E. Fitzgerald , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Jing Liu , Neelakandha S. Mani , Brad M. Savall
Inventor： Frank Chavez , Michael P. Curtis , James P. Edwards , Anne E. Fitzgerald , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Jing Liu , Neelakandha S. Mani , Brad M. Savall
IPC: A01N43/54 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC classification number: C07D491/048 , C07D491/147 , C07D495/04 , C07D519/00
Abstract: Benzofuro- and benzothienopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Abstract translation: 描述了苯并呋喃和苯并噻吩并嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于治疗由H 4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和瘙痒症。
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10.发明授权公开(公告)号：US08318718B2
公开(公告)日：2012-11-27
申请号：US12619573
申请日：2009-11-16
Applicant: Jennifer R. Allen , Biswas Kaustav , Frank Chavez , Ning Chen , Frenel Fils De Morin , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Roxanne Kunz , Holger Monenschein , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Guomin Yao
Inventor： Jennifer R. Allen , Biswas Kaustav , Frank Chavez , Ning Chen , Frenel Fils De Morin , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Roxanne Kunz , Holger Monenschein , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Guomin Yao
IPC: A61K31/4439 , A61K31/437 , A61K31/52 , A61K31/5377 , A61K31/55 , A61K31/397 , C07D401/12 , C07D471/04 , C07D473/00 , C07D413/14 , C07D401/14 , A61P25/00
CPC classification number: C07D413/14 , C07D401/12 , C07D401/14 , C07D417/12 , C07D471/04 , C07D473/00
Abstract: Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
Abstract translation: 吡啶和嘧啶化合物，以及含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症等。
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