公开(公告)号：US08822674B2

公开(公告)日：2014-09-02

申请号：US13816647

申请日：2011-08-19

申请人： Yoshihiro Kimura ,  Koreaki Imura ,  Naoto Osaki ,  Ayumi Matsushima

发明人： Yoshihiro Kimura ,  Koreaki Imura ,  Naoto Osaki ,  Ayumi Matsushima

IPC分类号： C07H7/04

CPC分类号： C07H15/203 ,  C07D309/10 ,  C07H1/00

摘要： A highly stable crystal of (1S)-1,5-anhydro-1-[5-(4-{(1E)-4-[(1-{[2-(dimethylamino)ethyl]amino}-2-methyl-1-oxopropan-2-yl)amino]-3,3-dimethyl-4-oxobut-1-en-1-yl}benzyl)-2-methoxy-4-(propan-2-yl)phenyl]-D-glucitol, and a process for producing the crystal are provided. Specifically, an ethanolate having the following physical properties, and a plurality of other crystal forms transformed from the ethanolate are provided: (a) Having peaks at 2θ=5.9 degrees, 17.1 degrees, 17.6 degrees and 21.5 degrees in X-ray powder diffraction (Cu—Kα); (b) Showing characteristic absorption bands at 3538 cm−1, 3357 cm−1, 2964 cm−1, 1673 cm−1, 1634 cm−1 and 1505 cm−1 in an infrared absorption spectrum; and (c) Having a melting point in a vicinity of 111° C.

摘要翻译： （1S）-1,5-脱水-1- [5-（4 - {（1E）-4 - [（1 - {[2-（二甲基氨基）乙基]氨基} -2-甲基 - -1-氧代丙-2-基）氨基] -3,3-二甲基-4-氧代丁-1-烯-1-基}苄基）-2-甲氧基-4-（丙-2-基）苯基] 葡萄糖醇，以及晶体的制造方法。 具体地说，提供具有以下物理性质的乙醇化物和从乙醇化物转化的多种其它晶体形式：（a）在X射线粉末衍射中在2θ= 5.9度，17.1度，17.6度和21.5度处具有峰值 （Cu-Kα）; （b）在红外吸收光谱中显示在3538cm-1,3337cm-1,2964cm-1,1673cm -1，1634cm -1和1505cm -1处的特征吸收带; 和（c）熔点在111℃附近

公开(公告)号：US20130144050A1

公开(公告)日：2013-06-06

申请号：US13816647

申请日：2011-08-19

申请人： Yoshihiro Kimura ,  Koreaki Imura ,  Naoto Osaki ,  Ayumi Matsushima

发明人： Yoshihiro Kimura ,  Koreaki Imura ,  Naoto Osaki ,  Ayumi Matsushima

IPC分类号： A61K31/7028 ,  C07H15/203 ,  C07H1/00

CPC分类号： C07H15/203 ,  C07D309/10 ,  C07H1/00

摘要： A highly stable crystal of (1S)-1,5-anhydro-1-[5-(4-{(1E)-4-[(1-{[2-(dimethylamino)ethyl]amino}-2-methyl-1-oxopropan-2-yl)amino]-3,3-dimethyl-4-oxobut-1-en-1-yl}benzyl)-2-methoxy-4-(propan-2-yl)phenyl]-D-glucitol, and a process for producing the crystal are provided. Specifically, an ethanolate having the following physical properties, and a plurality of other crystal forms transformed from the ethanolate are provided: (a) Having peaks at 2θ=5.9 degrees, 17.1 degrees, 17.6 degrees and 21.5 degrees in X-ray powder diffraction (Cu—Kα); (b) Showing characteristic absorption bands at 3538 cm−1, 3357 cm−1, 2964 cm−1, 1673 cm−1, 1634 cm−1 and 1505 cm−1 in an infrared absorption spectrum; and (c) Having a melting point in a vicinity of 111° C.

摘要翻译： （1S）-1,5-脱水-1- [5-（4 - {（1E）-4 - [（1 - {[2-（二甲基氨基）乙基]氨基} -2-甲基 - -1-氧代丙-2-基）氨基] -3,3-二甲基-4-氧代丁-1-烯-1-基}苄基）-2-甲氧基-4-（丙-2-基）苯基] 葡萄糖醇，以及晶体的制造方法。 具体地，提供具有以下物理性质的乙醇化物和从乙醇化物转化的多种其它晶体形式：（a）在X射线粉末衍射（2θ= 5.9度，17.1度，17.6度和21.5度）处具有峰值 Cu-Kalpha）; （b）在红外吸收光谱中显示在3538cm-1,3337cm-1,2964cm-1,1673cm -1，1634cm -1和1505cm -1处的特征吸收带; 和（c）熔点在111℃附近

公开(公告)号：US4163863A

公开(公告)日：1979-08-07

申请号：US877890

申请日：1978-02-15

申请人： Takeo Ikarashi ,  Mikio Goto ,  Kozo Sano ,  Naoto Osaki ,  Tetsuo Aoyama ,  Shigeru Horie

发明人： Takeo Ikarashi ,  Mikio Goto ,  Kozo Sano ,  Naoto Osaki ,  Tetsuo Aoyama ,  Shigeru Horie

IPC分类号： C07C37/08 ,  C07C39/07 ,  C07C39/06

CPC分类号： C07C37/08

摘要： A process for preparing a methylphenol from an alkylbenzene which process comprises oxidizing by molecular oxygen an alkylbenzene having one secondary alkyl group and 1-3 methyl groups of the general formula I ##STR1## where R is a secondary alkyl group and n is an integer of 1-3, acid-decomposing the oxidation product solution in the presence of an acid catalyst, stopping the acid-decomposition reaction before its completion, hydrogenating the acid decomposition product solution in the presence of a hydrogenation catalyst in the presence or absence of a solvent, and recovering the resulting methylphenol of the general formula II ##STR2## where n is an integer of 1-3 from the hydrogenation product solution.

公开(公告)号：US4013725A

公开(公告)日：1977-03-22

申请号：US574898

申请日：1975-05-06

申请人： Eiichi Yonemitsu ,  Takeo Igarashi ,  Naoto Osaki ,  Tetsuo Aoyama ,  Yukiya Nakazato

发明人： Eiichi Yonemitsu ,  Takeo Igarashi ,  Naoto Osaki ,  Tetsuo Aoyama ,  Yukiya Nakazato

IPC分类号： C07C409/08 ,  C07C179/02 ,  C07C179/04

CPC分类号： C07C409/08 ,  C07C407/00

摘要： A process for preparing hydroperoxide by autoxidizing secondary alkyl group-substituted methylbenzenes in the presence of water comprises using as a catalyst a water-soluble chelate compound in which multidentate ligands are coordinated to at least one member selected from the class of cobalt, nickel, manganese, copper and iron.