公开(公告)号：US5392781A

公开(公告)日：1995-02-28

申请号：US686420

申请日：1991-04-16

申请人： Patrick G. Phillipps ,  Paul Epstein ,  David G. Tweed

发明人： Patrick G. Phillipps ,  Paul Epstein ,  David G. Tweed

IPC分类号： A61B5/022 ,  A61B5/02 ,  A61B5/0225

CPC分类号： A61B5/02208 ,  A61B5/02

摘要： Several techniques are provided for aiding in the discrimination of detected biological signals indicative of blood pressure from detected signals not indicative of blood pressure (e.g., noise). A threshold, based predominantly on a level of noise, is developed and used in the discrimination. A second threshold, based predominantly on levels of previously detected biological signals, is developed and additionally used to help discriminate the biological signals from noise. The biological signals are detected during a selected portion of a cardiac cycle, and additional signals detected outside of the selected portion of the cycle are applied to the detected signals. Another threshold may be developed based predominantly on a level of signals sensed by a transducer positioned to preferentially sense noise; the transducer is positioned so that the noise that it detects is related to noise that is detected during the detection of the biological signals. Blood pressure is measured during periodically scheduled measurement cycles, and a measurement cycle is suspended if noise exceeds a predetermined level. The times at which the detected signals (i.e., the signals indicative of blood pressure and the signals not indicative of blood pressure) are processed during a given cardiac cycle are selected based at least in part on the pressure of the cuff. The biological signals indicative of blood pressure that are detected during a current measurement cycle are used to at least in part determine the times at which the detected signals will be processed during a succeeding measurement cycle.

摘要翻译： 提供了几种技术来帮助鉴别从未指示血压（例如，噪声）的检测信号指示血压的检测到的生物信号。 基于噪音水平的阈值主要用于歧视。 开发了主要基于先前检测到的生物信号的水平的第二阈值，并且另外用于帮助区分生物信号与噪声。 在心脏周期的选定部分期间检测生物信号，并且在周期的选定部分之外检测到的附加信号被应用于检测到的信号。 可以主要基于被定位成优先感测噪声的换能器感测的信号的水平来开发另一个阈值; 换能器被定位成使得其检测到的噪声与在生物信号的检测期间检测到的噪声相关。 在周期性调度的测量循环期间测量血压，并且如果噪声超过预定水平，则测量循环被暂停。 至少部分地基于袖带的压力选择在给定的心动周期期间处理检测到的信号（即，指示血压的信号和不指示血压的信号）的时间。 指示在当前测量周期期间检测到的血压的生物信号用于至少部分地确定在随后的测量周期期间检测到的信号将被处理的时间。

公开(公告)号：USD519366S1

公开(公告)日：2006-04-25

申请号：US29213944

申请日：2004-09-24

申请人： Paul Epstein

设计人： Paul Epstein

公开(公告)号：US20050148885A1

公开(公告)日：2005-07-07

申请号：US10922826

申请日：2004-08-20

申请人： David Tweed ,  Patrick Phillipps ,  Paul Epstein

发明人： David Tweed ,  Patrick Phillipps ,  Paul Epstein

IPC分类号： A61B5/02 ,  A61B5/021 ,  A61B5/022 ,  A61B5/0225

CPC分类号： A61B5/02241 ,  A61B5/0048 ,  A61B5/021 ,  A61B5/02116 ,  A61B5/02225 ,  A61B5/02255 ,  A61B5/411 ,  A61B5/7285 ,  A61B2562/0233

摘要： The apparatus and methods of the present invention provide a non-invasive measurement of blood pressure with a frequency that approximates a continuous measurement. Blood pressure measurement provides information that is both clinically and diagnostically significant. In accordance with an aspect of the present invention, a method for providing a non-invasive measurement of blood pressure, includes obtaining a first input signal and a second input signal indicative of occlusive measurements of systolic blood pressure and diastolic blood pressure, respectively; tracking a signal indicative of pulse pressure; continuously measuring a third signal indicative of mean blood pressure; and processing the signals to obtain a measurement indicative of systolic and diastolic blood pressure, wherein at least a portion of the measurement indicative of systolic and diastolic blood pressure is continuous. The second input signal indicative of diastolic blood pressure is analyzed to identify a maximum amplitude of the signal, the maximum amplitude being indicative of the diastolic blood pressure measurement.

摘要翻译： 本发明的装置和方法以近似连续测量的频率提供血压的非侵入式测量。 血压测量提供了临床和诊断上显着的信息。 根据本发明的一个方面，提供一种用于提供血压无创测量的方法，包括分别获得指示收缩压和舒张压的闭塞测量的第一输入信号和第二输入信号; 跟踪指示脉压的信号; 连续地测量指示平均血压的第三信号; 以及处理所述信号以获得指示收缩压和舒张压的测量值，其中指示收缩压和舒张压的测量的至少一部分是连续的。 分析指示舒张压的第二输入信号以识别信号的最大振幅，最大振幅指示舒张压测量。

公开(公告)号：US5100380A

公开(公告)日：1992-03-31

申请号：US355035

申请日：1989-05-16

申请人： Paul Epstein ,  Harry Petschek ,  Eric LaWhite ,  Clair Strohl ,  Henry Coyne ,  Edward Kaleskas ,  George Adaniya

发明人： Paul Epstein ,  Harry Petschek ,  Eric LaWhite ,  Clair Strohl ,  Henry Coyne ,  Edward Kaleskas ,  George Adaniya

IPC分类号： A61M5/142 ,  A61M5/168 ,  A61M5/172

CPC分类号： A61M5/172 ,  A61M5/14224 ,  A61M2005/1402 ,  A61M2005/14208 ,  A61M5/16827 ,  Y10S128/12 ,  Y10S128/13

摘要： An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectively operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode. The system is operative to adapt actual to desired flow rates in normal operation. All fluids flow through a unitary disposable cassette without making any other system contact. Air bubbles in the fluid line are automatically detected and disposed of. Fluid pressures are monitored and system operation adjusted as a function of such pressures. Infusates may be administered from syringes as well as from standard bag or bottle containers. Infusate from a selected input port may be controllably pumped into a syringe for unsticking the syringe plunger. The system is selectively operable to adjust total fluid volume and rate to below preselected values for patients whose total fluid intake must be restricted. The system is operable to maintain an accurate record of total infusion history. The system may be controlled by a terminal or a computer located remotely from the patient location. The system may include auxiliary pumps in addition to a primary pump, all controlled by a single computer.

摘要翻译： 一种输注系统，用于以多个流体输入端口中的任何一个或多个通过患者输出端口并进入患者的循环系统，以单独可编程的速率，体积和顺序管理多个输注物。 输注物可以是连续的或时间依次施用的，并且输注物可以间歇地以选择性的定期间隔或时间重叠施用以施用稀释。 自动检测各种错误条件，并在发生冲突时产生警报，识别不输注的时间，并识别系统故障。 该系统可以选择性地可操作地在启动模式，维护模式，正常模式和手动超控模式中。 该系统可操作以在正常操作中使实际适应期望的流速。 所有的流体都流经整体的一次性盒式磁带，而不会使任何其他系统接触。 流体管路中的气泡被自动检测并处理。 监测流体压力并根据这种压力调整系统运行。 注射器可以从注射器以及标准袋或瓶容器中进行施用。 从选择的输入端口输注可以可控地泵送到注射器中用于取消对注射器柱塞的取出。 该系统可选择性地可操作地调整总体积体积并且对于总流体摄取必须被限制的患者的速率低于预选值。 该系统可操作以保持总输液历史的准确记录。 系统可以由远离患者位置的终端或计算机控制。 该系统可以包括除主泵之外的辅助泵，全部由单个计算机控制。

公开(公告)号：US4865584A

公开(公告)日：1989-09-12

申请号：US39314

申请日：1987-04-16

申请人： Paul Epstein ,  Harry Petschek ,  Eric LaWhite ,  Clair Strohl ,  Henry Coyne ,  Edward Kaleskas ,  George Adaniya

发明人： Paul Epstein ,  Harry Petschek ,  Eric LaWhite ,  Clair Strohl ,  Henry Coyne ,  Edward Kaleskas ,  George Adaniya

IPC分类号： A61M5/142 ,  A61M5/168 ,  A61M5/172

CPC分类号： A61M5/172 ,  A61M5/14224 ,  A61M2005/1402 ,  A61M2005/14208 ,  A61M5/16827

摘要： An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectivley operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode. The system is operative to adapt actual to desired flow rates in normal operation. All fluids flow through a unitary disposable cassette without making any other system contact. Air bubbles in the fluid line are automatically detected and disposed of. Fluid pressures are monitored and system operation adjusted as a function of such pressures. Infusates may be administered from syringes as well as from standard bag or bottle containers. Infusate from a selected input port may be controllably pumped into a syringe for unsticking the syringe plunger. The system is selectivley operable to adjust total fluid volume and rate to below preselected values for patients whose total fluid intake must be restricted. The system is operable to maintain an accurate record of total infusion history.

摘要翻译： 一种输注系统，用于以多个流体输入端口中的任何一个或多个通过患者输出端口并进入患者的循环系统，以单独可编程的速率，体积和顺序管理多个输注物。 输注物可以是连续的或时间依次施用的，并且输注物可以间歇地以选择性的定期间隔或时间重叠施用以施用稀释。 自动检测各种错误条件，并在发生冲突时产生警报，识别不输注的时间，并识别系统故障。 该系统是选择性操作的，其中包括起动模式，维护模式，正常模式和手动超驰模式。 该系统可操作以在正常操作中使实际适应期望的流速。 所有的流体都流经整体的一次性盒式磁带，而不会使任何其他系统接触。 流体管路中的气泡被自动检测并处理。 监测流体压力并根据这种压力调整系统运行。 注射器可以从注射器以及标准袋或瓶容器中进行施用。 从选择的输入端口输注可以可控地泵送到注射器中用于取消对注射器柱塞的取出。 该系统是选择性可操作的，用于调整总体积体积，并将速率调整到低于预选值，对于总流体摄入必须限制的患者。 该系统可操作以保持总输液历史的准确记录。

公开(公告)号：US4828545A

公开(公告)日：1989-05-09

申请号：US39154

申请日：1987-04-16

申请人： Paul Epstein ,  Harry Petschek ,  Eric LaWhite ,  Clair Strohl ,  Henry Coyne ,  Edward Kaleskas ,  George Adaniya

发明人： Paul Epstein ,  Harry Petschek ,  Eric LaWhite ,  Clair Strohl ,  Henry Coyne ,  Edward Kaleskas ,  George Adaniya

IPC分类号： A61M5/142 ,  A61M5/168 ,  A61M5/172

CPC分类号： A61M5/172 ,  A61M5/14224 ,  A61M2005/1402 ,  A61M2005/14208 ,  A61M5/16827

摘要： An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectively operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode. The system is operative to adapt actual to desired flow rates in normal operation. All fluids flow through a unitary disposable cassette without making any other system contact. Air bubbles in the fluid line are automatically detected and disposed of. Fluid pressures are monitored and system operation adjusted as a function of such pressures. Infusates may be administered from syringes as well as from standard bag or bottle containers. Infusate from a selected input port may be controllably pumped into a syringe for unsticking the syringe plunger. The system is selectively operable to adjust total fluid volume and rate to below preselected values for patients whose total fluid intake must be restricted. The system is operable to maintain an accurate record of total infusion history.

摘要翻译： 一种输注系统，用于以多个流体输入端口中的任何一个或多个通过患者输出端口并进入患者的循环系统，以单独可编程的速率，体积和顺序管理多个输注物。 输注物可以是连续的或时间依次施用的，并且输注物可以间歇地以选择性的定期间隔或时间重叠施用以施用稀释。 自动检测各种错误条件，并在发生冲突时产生警报，识别不输注的时间，并识别系统故障。 该系统可以选择性地可操作地在启动模式，维护模式，正常模式和手动超控模式中。 该系统可操作以在正常操作中使实际适应期望的流速。 所有的流体都流经整体的一次性盒式磁带，而不会使任何其他系统接触。 流体管路中的气泡被自动检测并处理。 监测流体压力并根据这种压力调整系统运行。 注射器可以从注射器以及标准袋或瓶容器中进行施用。 从选择的输入端口输注可以可控地泵送到注射器中用于取消对注射器柱塞的取出。 该系统可选择性地可操作地调整总体积体积并且对于总流体摄取必须被限制的患者的速率低于预选值。 该系统可操作以保持总输液历史的准确记录。

公开(公告)号：US20220134241A1

公开(公告)日：2022-05-05

申请号：US17647831

申请日：2022-01-12

申请人： Justin Paul Epstein ,  Joshua Jacques Slocumb

发明人： Justin Paul Epstein ,  Joshua Jacques Slocumb

IPC分类号： A63F13/98 ,  F16M11/04

摘要： A mount, that includes a first ring adapted to allow a first grip of a handheld device to pass partially therethrough, that includes a first ring outer portion adapted to prevent lateral movement of the first grip, and a second ring adapted to allow a second grip of the handheld device to pass partially therethrough, that includes a second ring outer portion adapted to prevent lateral movement of the second grip.

公开(公告)号：USRE36871E

公开(公告)日：2000-09-12

申请号：US401339

申请日：1995-03-09

申请人： Paul Epstein ,  Harry Petschek ,  Eric LaWhite ,  Clair Strohl ,  Henry Coyne ,  Edward Kaleskas ,  George Adaniya

发明人： Paul Epstein ,  Harry Petschek ,  Eric LaWhite ,  Clair Strohl ,  Henry Coyne ,  Edward Kaleskas ,  George Adaniya

IPC分类号： A61M5/00 ,  A61M5/142 ,  A61M5/168 ,  A61M5/172 ,  A61M31/00

CPC分类号： A61M5/14224 ,  A61M5/172 ,  A61M2005/14208 ,  A61M5/16827 ,  Y10S128/13

摘要： An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectively operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode. The system is operative to adapt actual to desired flow rates in normal operation. All fluids flow through a unitary disposable cassette without making any other system contact. Air bubbles in the fluid line are automatically detected and disposed of. Fluid pressures are monitored and system operation adjusted as a function of such pressures. Infusates may be administered from syringes as well as from standard bag or bottle containers. Infusate from a selected input port may be controllably pumped into a syringe for unsticking the syringe plunger. The system is selectively operable to adjust total fluid volume and rate to below preselected values for patients whose total fluid intake must be restricted. The system is operable to maintain an accurate record of total infusion history. The system may be controlled by a terminal or a computer located remotely from the patient location. The system may include auxiliary pumps in addition to a primary pump, all controlled by a single computer.

公开(公告)号：US4489726A

公开(公告)日：1984-12-25

申请号：US318339

申请日：1981-11-05

申请人： Paul Epstein ,  John S. Ballas, Jr. ,  John J. Mandler, Jr. ,  Joseph M. Van Horn

发明人： Paul Epstein ,  John S. Ballas, Jr. ,  John J. Mandler, Jr. ,  Joseph M. Van Horn

IPC分类号： A61B5/024 ,  G06F17/00 ,  A61N5/00

CPC分类号： A61B5/02411 ,  A61B5/4362 ,  A61B8/02 ,  A61B8/0866

摘要： Apparatus and method for continuously monitoring the fetal heart rate simultaneously using ultrasonic and electrocardiographic signals. The signals are continuously processed to provide an improved output fetal heart rate indication in terms of better continuity and accuracy.

摘要翻译： 使用超声波和心电图信号同时连续监测胎儿心率的装置和方法。 在更好的连续性和准确性方面，信号被连续处理以提供改进的输出胎儿心率指示。

公开(公告)号：US20140136627A1

公开(公告)日：2014-05-15

申请号：US14099735

申请日：2013-12-06

申请人： Paul EPSTEIN

发明人： Paul EPSTEIN

IPC分类号： H04L29/06

CPC分类号： H04L65/403 ,  G06Q10/109 ,  G06Q10/1095

摘要： Facilitating a meeting is described. The method comprises providing a network interface for receiving information via a network, and receiving, at the network interface, meeting information in respect of a meeting. The meeting information includes information that is indicative of at least one agenda item. The method also comprises providing a meeting structure information generator for generating meeting structure information based on received meeting information and generating, at the meeting structure information generator, meeting structure information based on the meeting information. The generated meeting structure information is provided to at least one meeting participant for use in facilitating the meeting. In a further step, agenda outcome information that is indicative of at least one outcome of the agenda item is received at the network interface. A meeting report information generator for generating meeting report information is used to generate meeting report information based on the received agenda outcome information.

摘要翻译： 描述了促进会议。 该方法包括：提供用于经由网络接收信息的网络接口，以及在网络接口处接收关于会议的会议信息。 会议信息包括指示至少一个议程项目的信息。 该方法还包括提供一种会议结构信息发生器，用于基于接收到的会议信息产生会议结构信息，并在会议结构信息生成器处根据会议信息生成会议结构信息。 生成的会议结构信息被提供给至少一个会议参与者以便于会议。 在另一步骤中，在网络接口处接收表示议程项目的至少一个结果的议程结果信息。 用于生成会议报告信息的会议报告信息生成器用于根据接收的议程结果信息生成会议报告信息。