公开(公告)号：US20080306045A1

公开(公告)日：2008-12-11

申请号：US12094707

申请日：2006-11-22

申请人： Laure Camus ,  Reshma Chudasama ,  Caroline Jane Day ,  Deepali Deshmukh ,  John Gerald Gleason ,  John David Harling ,  Chao-Pin Lee ,  Paula Saklatvala ,  Stefan Senger ,  Sarah Vallance ,  John Watson ,  Nigel Stephen Watson ,  Robert John Young ,  Barbara Yuan

发明人： Laure Camus ,  Reshma Chudasama ,  Caroline Jane Day ,  Deepali Deshmukh ,  John Gerald Gleason ,  John David Harling ,  Chao-Pin Lee ,  Paula Saklatvala ,  Stefan Senger ,  Sarah Vallance ,  John Watson ,  Nigel Stephen Watson ,  Robert John Young ,  Barbara Yuan

IPC分类号： A61K31/55 ,  C07D409/14 ,  C07D403/10 ,  C07D403/14

CPC分类号： C07D409/14 ,  C07D403/04 ,  C07D403/14

摘要： The invention relates to chemical entities of formula (I): and/or pharmaceutically acceptable derivative(s) thereof. The invention also relates to processes for the preparation of compounds of formula (I), pharmaceutical compositions containing compounds of formula (I) and to the use of compounds of formula (I) in medicine, particularly in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.

摘要翻译： 本发明涉及式（I）的化学实体：和/或其药学上可接受的衍生物。 本发明还涉及制备式（I）化合物的方法，含有式（I）化合物的药物组合物和式（I）化合物在医药中的应用，特别是在改善临床病症方面 指示因子Xa抑制剂。