公开(公告)号：US20120053150A1

公开(公告)日：2012-03-01

申请号：US13265037

申请日：2010-04-22

申请人： David George Allen ,  Diane Mary Coe ,  Anthony William James Cooper ,  Paul Martin Gore ,  David House ,  Stefan Senger ,  Steven Leslie Sollis ,  Sadie Vile ,  Caroline Wilson

发明人： David George Allen ,  Diane Mary Coe ,  Anthony William James Cooper ,  Paul Martin Gore ,  David House ,  Stefan Senger ,  Steven Leslie Sollis ,  Sadie Vile ,  Caroline Wilson

IPC分类号： A61K31/675 ,  C07D401/12 ,  C07D403/10 ,  C07D413/10 ,  C07D413/12 ,  C07D403/12 ,  C07F9/6503 ,  A61K31/415 ,  A61K31/4439 ,  A61K31/4245 ,  A61K31/422 ,  A61K31/513 ,  A61P11/06 ,  A61P29/00 ,  C07D231/40

CPC分类号： C07D231/40

摘要： The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.

摘要翻译： 本发明涉及酰胺化合物，其制备方法，含有这些化合物的药物组合物及其用于治疗疾病，病症或病症如过敏性疾病，炎症性疾病和免疫系统疾病的用途。

公开(公告)号：US07326785B2

公开(公告)日：2008-02-05

申请号：US11548404

申请日：2006-10-11

申请人： Chuen Chan ,  Julie Nicole Hamblin ,  Henry Anderson Kelly ,  Nigel Paul King ,  Andrew McMurtrie Mason ,  Vipulkumar Kantibhai Patel ,  Stefan Senger ,  Gita Punjabhai Shah ,  Nigel Stephen Watson ,  Helen Elisabeth Weston ,  Caroline Whitworth ,  Robert John Young

发明人： Chuen Chan ,  Julie Nicole Hamblin ,  Henry Anderson Kelly ,  Nigel Paul King ,  Andrew McMurtrie Mason ,  Vipulkumar Kantibhai Patel ,  Stefan Senger ,  Gita Punjabhai Shah ,  Nigel Stephen Watson ,  Helen Elisabeth Weston ,  Caroline Whitworth ,  Robert John Young

IPC分类号： C07D413/14

CPC分类号： C07D413/14 ,  A61K31/5377 ,  C07D207/12 ,  C07D413/06 ,  C07D417/14 ,  C07D495/04

摘要： The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.

摘要翻译： 本发明涉及式（I）化合物的制备方法，含有它们的药物组合物及其在医药中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。

公开(公告)号：US07282497B2

公开(公告)日：2007-10-16

申请号：US11384094

申请日：2006-03-17

申请人： Chuen Chan ,  Julie Nicole Hamblin ,  Henry Anderson Kelly ,  Nigel Paul King ,  Andrew McMurtrie Mason ,  Vipulkumar Kantibhai Patel ,  Stefan Senger ,  Gita Punjabhai Shah ,  Nigel Stephen Watson ,  Helen Elisabeth Weston ,  Caroline Whitworth ,  Robert John Young

发明人： Chuen Chan ,  Julie Nicole Hamblin ,  Henry Anderson Kelly ,  Nigel Paul King ,  Andrew McMurtrie Mason ,  Vipulkumar Kantibhai Patel ,  Stefan Senger ,  Gita Punjabhai Shah ,  Nigel Stephen Watson ,  Helen Elisabeth Weston ,  Caroline Whitworth ,  Robert John Young

IPC分类号： C07D409/14 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/454

CPC分类号： A61K9/0031 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0043 ,  A61K9/0056 ,  A61K9/0073 ,  A61K9/0095 ,  A61K9/02 ,  A61K9/12 ,  A61K31/4025 ,  A61K31/454 ,  A61K38/00 ,  C07K5/06034 ,  C07K5/06139 ,  C07K5/06191

摘要： The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.

公开(公告)号：US07226929B2

公开(公告)日：2007-06-05

申请号：US11378947

申请日：2006-03-17

申请人： Chuen Chan ,  Julie Nicole Hamblin ,  Henry Anderson Kelly ,  Nigel Paul King ,  Andrew McMurtrie Mason ,  Vipulkumar Kantibhai Patel ,  Stefan Senger ,  Gita Punjabhai Shah ,  Nigel Stephen Watson ,  Helen Elisabeth Weston ,  Caroline Whitworth ,  Robert John Young

发明人： Chuen Chan ,  Julie Nicole Hamblin ,  Henry Anderson Kelly ,  Nigel Paul King ,  Andrew McMurtrie Mason ,  Vipulkumar Kantibhai Patel ,  Stefan Senger ,  Gita Punjabhai Shah ,  Nigel Stephen Watson ,  Helen Elisabeth Weston ,  Caroline Whitworth ,  Robert John Young

IPC分类号： C07D211/56 ,  C07D215/14 ,  A61K31/454 ,  A61K31/437 ,  A61K31/4545

CPC分类号： A61K9/0031 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0043 ,  A61K9/0056 ,  A61K9/0073 ,  A61K9/0095 ,  A61K9/02 ,  A61K9/12 ,  A61K31/4025 ,  A61K31/454 ,  A61K38/00 ,  C07K5/06034 ,  C07K5/06139 ,  C07K5/06191

摘要： The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.

摘要翻译： 本发明涉及式（Ic）化合物的制备方法，含有它们的药物组合物及其在药物中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。

公开(公告)号：US07084139B2

公开(公告)日：2006-08-01

申请号：US10479534

申请日：2002-06-06

申请人： Chuen Chan ,  Julie Nicole Hamblin ,  Henry Anderson Kelly ,  Nigel Paul King ,  Andrew McMurtrie Mason ,  Vipulkumar Kantibhai Patel ,  Stefan Senger ,  Gita Punjabhai Shah ,  Nigel Stephen Watson ,  Helen Elisabeth Weston ,  Caroline Whitworth ,  Robert John Young

发明人： Chuen Chan ,  Julie Nicole Hamblin ,  Henry Anderson Kelly ,  Nigel Paul King ,  Andrew McMurtrie Mason ,  Vipulkumar Kantibhai Patel ,  Stefan Senger ,  Gita Punjabhai Shah ,  Nigel Stephen Watson ,  Helen Elisabeth Weston ,  Caroline Whitworth ,  Robert John Young

IPC分类号： A61K51/5377 ,  A61K31/4015 ,  C07D413/414 ,  C07D207/12

CPC分类号： A61K9/0031 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0043 ,  A61K9/0056 ,  A61K9/0073 ,  A61K9/0095 ,  A61K9/02 ,  A61K9/12 ,  A61K31/4025 ,  A61K31/454 ,  A61K38/00 ,  C07K5/06034 ,  C07K5/06139 ,  C07K5/06191

摘要： The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.

摘要翻译： 本发明涉及式（Ic）化合物的制备方法，含有它们的药物组合物及其在药物中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。

公开(公告)号：US08399436B2

公开(公告)日：2013-03-19

申请号：US13265037

申请日：2010-04-22

申请人： David George Allen ,  Diane Mary Coe ,  Anthony William James Cooper ,  Paul Martin Gore ,  David House ,  Stefan Senger ,  Steven Leslie Sollis ,  Sadie Vile ,  Caroline Wilson

发明人： David George Allen ,  Diane Mary Coe ,  Anthony William James Cooper ,  Paul Martin Gore ,  David House ,  Stefan Senger ,  Steven Leslie Sollis ,  Sadie Vile ,  Caroline Wilson

IPC分类号： A61K31/675 ,  A61K31/415 ,  A61K31/4439 ,  A61K31/4245 ,  A61K31/513 ,  A61P11/06 ,  C07D401/12 ,  C07D403/10 ,  C07D413/12

CPC分类号： C07D231/40

摘要： The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.

摘要翻译： 本发明涉及酰胺化合物，其制备方法，含有这些化合物的药物组合物及其用于治疗疾病，病症或病症如过敏性疾病，炎症性疾病和免疫系统疾病的用途。

公开(公告)号：US20120035237A1

公开(公告)日：2012-02-09

申请号：US13265031

申请日：2010-04-22

申请人： Diane Mary Coe ,  Anthony William James Cooper ,  Paul Martin Gore ,  David House ,  Stefan Senger ,  Sadie Vile

发明人： Diane Mary Coe ,  Anthony William James Cooper ,  Paul Martin Gore ,  David House ,  Stefan Senger ,  Sadie Vile

IPC分类号： A61K31/415 ,  A61P11/00 ,  A61K31/4192 ,  A61P11/06 ,  C07D231/12 ,  C07D249/04

CPC分类号： C07D231/14 ,  C07D249/04

摘要： The present invention relates to amide compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing these compounds and to their use in therapy.

摘要翻译： 本发明涉及酰胺化合物，其制备方法，可用于这些方法的中间体，含有这些化合物的药物组合物及其在治疗中的用途。

公开(公告)号：US07429587B2

公开(公告)日：2008-09-30

申请号：US11548395

申请日：2006-10-11

申请人： Chuen Chan ,  Julie Nicole Hamblin ,  Henry Anderson Kelly ,  Nigel Paul King ,  Andrew McMurtrie Mason ,  Vipulkumar Kantibhai Patel ,  Stefan Senger ,  Gita Punjabhai Shah ,  Nigel Stephen Watson ,  Helen Elisabeth Weston ,  Caroline Whitworth ,  Robert John Young

发明人： Chuen Chan ,  Julie Nicole Hamblin ,  Henry Anderson Kelly ,  Nigel Paul King ,  Andrew McMurtrie Mason ,  Vipulkumar Kantibhai Patel ,  Stefan Senger ,  Gita Punjabhai Shah ,  Nigel Stephen Watson ,  Helen Elisabeth Weston ,  Caroline Whitworth ,  Robert John Young

IPC分类号： A61K31/5377 ,  C07D413/06

CPC分类号： C07D413/14 ,  A61K31/5377 ,  C07D207/12 ,  C07D413/06 ,  C07D417/14 ,  C07D495/04

摘要： The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.

摘要翻译： 本发明涉及式（I）化合物的制备方法，含有它们的药物组合物及其在医药中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。

公开(公告)号：US20060160885A1

公开(公告)日：2006-07-20

申请号：US11378947

申请日：2006-03-17

申请人： Chuen Chan ,  Julie Hamblin ,  Henry Kelly ,  Nigel King ,  Andrew Mason ,  Vipulkumar Patel ,  Stefan Senger ,  Gita Shah ,  Nigel Watson ,  Helen Weston ,  Caroline Whitworth ,  Robert Young

发明人： Chuen Chan ,  Julie Hamblin ,  Henry Kelly ,  Nigel King ,  Andrew Mason ,  Vipulkumar Patel ,  Stefan Senger ,  Gita Shah ,  Nigel Watson ,  Helen Weston ,  Caroline Whitworth ,  Robert Young

IPC分类号： A61K31/4015 ,  A61K31/4025 ,  C07D403/02

CPC分类号： A61K9/0031 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0043 ,  A61K9/0056 ,  A61K9/0073 ,  A61K9/0095 ,  A61K9/02 ,  A61K9/12 ,  A61K31/4025 ,  A61K31/454 ,  A61K38/00 ,  C07K5/06034 ,  C07K5/06139 ,  C07K5/06191

摘要： The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.

摘要翻译： 本发明涉及式（Ic）化合物的制备方法，含有它们的药物组合物及其在药物中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。

公开(公告)号：US06547186B2

公开(公告)日：2003-04-15

申请号：US10188041

申请日：2002-07-03

申请人： Stefan Senger

发明人： Stefan Senger

IPC分类号： B64C114

CPC分类号： B64C1/143 ,  B64C1/1407

摘要： A device for opening a passenger door of an aircraft includes a supporting arm connected movably to the fuselage frame, a wishbone connecting the support arm to the passenger door, a first journal rotatably connecting the wishbone to the support arm, and a lifting mechanism. The lifting mechanism includes a lifting shaft for raising and lowering the door, a lowering safety shaft, a controllable drive engaged with the lowering safety shaft to rotate lowering safety shaft, and a lowering safety link. The lifting shaft includes two ends and a roller lever disposed at each end, wherein when the passage door is in the closed position, each roller lever engages a fuselage frame mounting. The lowering safety shaft includes an end and a roller lever disposed at the end. The lowering safety shaft is engaged with the lifting shaft. The lowering safety link includes a second journal having an elongated configuration. The second journal has a link track, and the roller of the lowering safety shaft is guided on the link track of the second journal.