COMPOSITION AND PROCESS FOR SYNTHESIZING POLYMERIZED HUMAN SERUM ALBUMIN FOR APPLICATIONS IN TRANSFUSION MEDICINE
    6.
    发明申请
    COMPOSITION AND PROCESS FOR SYNTHESIZING POLYMERIZED HUMAN SERUM ALBUMIN FOR APPLICATIONS IN TRANSFUSION MEDICINE 审中-公开
    用于合成聚合人血清白蛋白的组合物和方法用于转移医学应用

    公开(公告)号:US20120046231A1

    公开(公告)日:2012-02-23

    申请号:US13215473

    申请日:2011-08-23

    IPC分类号: A61K38/38 A61P7/00 C07K14/765

    CPC分类号: A61K38/38

    摘要: Described herein is a composition and process for synthesizing a human serum albumin (HSA) based plasma replacement composition that includes a polymerized HSA (PolyHSA) that is chemically stabilized by the reduction of Schiff bases. The PolyHSA may have a molecular weight of at least about 100 kDa and may optionally have a cross-linker to HSA molar ratio of at least about 10:1. The PolyHSA composition is useful for restoring a subject's circulatory volume.

    摘要翻译: 本文描述的是用于合成基于血浆白蛋白(HSA)的血浆置换组合物的组合物和方法,其包括通过还原希夫碱化学稳定的聚合的HSA(PolyHSA)。 PolyHSA可以具有至少约100kDa的分子量,并且可以任选地具有至少约10:1的HSA摩尔比的交联剂。 PolyHSA组合物可用于恢复受试者的循环体积。