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1.发明授权Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof 有权抗增殖化合物，其缀合物，其方法及其应用公开(公告)号：US08394922B2
公开(公告)日：2013-03-12
申请号：US12846493
申请日：2010-07-29
申请人： Heng Cheng , Qiang Cong , Sanjeev Gangwar
发明人： Heng Cheng , Qiang Cong , Sanjeev Gangwar
IPC分类号： C07K5/00
CPC分类号： C07K7/06 , A61K38/06 , A61K47/6811 , A61K47/6829 , C07C229/14 , C07C229/16 , C07K5/021 , C07K5/06139 , C07K5/10 , C07K16/18
摘要： Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
摘要翻译： 具有由式（II）表示的结构的抗增殖化合物，其中n，R 1，R 2，R 3，R 4和R 5如本文所定义，可任选地当与配体例如抗体缀合时用于治疗肿瘤：
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公开(公告)号：US07576094B2
公开(公告)日：2009-08-18
申请号：US11298137
申请日：2005-12-09
申请人： Daniel T. W. Chu , Jian Chen , Wei Zhang , Xianfeng Li , Jiangao Song , Bing Wang , Qiang Cong , Donald R. James
发明人： Daniel T. W. Chu , Jian Chen , Wei Zhang , Xianfeng Li , Jiangao Song , Bing Wang , Qiang Cong , Donald R. James
IPC分类号： A61K31/353 , A61K31/382 , A61K31/4353 , C07D221/20 , C07D311/96 , C07D335/04
CPC分类号： C07D221/20 , C07D311/96 , C07D335/04 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D407/04 , C07D413/04 , C07D417/04
摘要： The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful in the manufacture of pharmaceutical formulations for the treatment of lipoxygenase-mediated disorders.
摘要翻译： 本发明涉及某些新的螺取代杂环衍生物。 这些化合物可用于制备用于治疗由脂肪氧合酶介导的病症的药物组合物。 它们也可用于制备用于治疗脂氧合酶介导的病症的药物制剂。
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3.发明申请ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF 有权抗生素化合物，其结合物及其用途及其用途公开(公告)号：US20110027274A1
公开(公告)日：2011-02-03
申请号：US12846493
申请日：2010-07-29
申请人： Heng Cheng , Qiang Cong , Sanjeev Gangwar , Qian Zhang
发明人： Heng Cheng , Qiang Cong , Sanjeev Gangwar , Qian Zhang
IPC分类号： A61K39/395 , C07K5/10 , C07K16/00 , C07C205/00 , C07C229/00
CPC分类号： C07K7/06 , A61K38/06 , A61K47/6811 , A61K47/6829 , C07C229/14 , C07C229/16 , C07K5/021 , C07K5/06139 , C07K5/10 , C07K16/18
摘要： Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
摘要翻译： 具有由式（II）表示的结构的抗增殖化合物，其中n，R 1，R 2，R 3，R 4和R 5如本文所定义，可任选地当与配体例如抗体缀合时用于治疗肿瘤：
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公开(公告)号：US20060128790A1
公开(公告)日：2006-06-15
申请号：US11298137
申请日：2005-12-09
申请人： Daniel Chu , Jian Chen , Wei Zhang , Xianfeng Li , Jiangao Song , Bing Wang , Qiang Cong , Donald James
发明人： Daniel Chu , Jian Chen , Wei Zhang , Xianfeng Li , Jiangao Song , Bing Wang , Qiang Cong , Donald James
IPC分类号： A61K31/382 , A61K31/353 , C07D335/10 , C07D317/72
CPC分类号： C07D221/20 , C07D311/96 , C07D335/04 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D407/04 , C07D413/04 , C07D417/04
摘要： The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful in the manufacture of pharmaceutical formulations for the treatment of lipoxygenase-mediated disorders.
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