公开(公告)号：US12083101B2

公开(公告)日：2024-09-10

申请号：US17201268

申请日：2021-03-15

申请人： Novartis AG

发明人： Vincent Bordas ,  Cara Brocklehurst ,  Patrick Chene ,  Pascal Furet ,  Vito Guagnano ,  Patricia Imbach-Weese ,  Joerg Kallen ,  Mickael Le Douget ,  Edwige Liliane Jeanne Lorthiois ,  Joseph McKenna ,  Bahaa Salem ,  Tobias Schmelzle ,  Holger Sellner ,  Nicolas Soldermann ,  Markus Voegtle ,  Markus Wartmann

IPC分类号： A61K31/4155 ,  A61K31/343 ,  A61K31/351 ,  A61K31/357 ,  A61K31/4025 ,  A61K31/403 ,  A61K31/404 ,  A61K31/41 ,  A61K31/426 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/4525 ,  A61K31/506 ,  A61P35/00 ,  C07D307/81 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04 ,  C07D407/12 ,  C07D413/04 ,  C07D417/04 ,  C07D491/04

CPC分类号： A61K31/4155 ,  A61K31/343 ,  A61K31/351 ,  A61K31/357 ,  A61K31/4025 ,  A61K31/403 ,  A61K31/41 ,  A61K31/426 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/4525 ,  A61K31/506 ,  A61P35/00 ,  C07D307/81 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04 ,  C07D407/12 ,  C07D417/04

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;






a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

公开(公告)号：US20240270709A1

公开(公告)日：2024-08-15

申请号：US18289365

申请日：2022-05-12

申请人： SFC CO., LTD.

发明人： Si-In KIM ,  Se-Jin LEE ,  Seok-Bae PARK ,  Hee-Dae KIM ,  Yeong-Tae CHOI ,  Ji-Ying KIM ,  Kyungtae KIM ,  Myeong-Jun KIM ,  Kyeong-Hyeon KIM ,  Seung-Soo LEE ,  Tae Gyun LEE ,  Joon-Ho KIM

IPC分类号： C07D307/79 ,  C07D307/92 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D407/14 ,  C07D409/14 ,  C07D491/04 ,  C07D493/04 ,  C09K11/06 ,  H10K50/12 ,  H10K85/60

CPC分类号： C07D307/79 ,  C07D307/92 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D407/14 ,  C07D409/14 ,  C07D491/04 ,  C07D493/04 ,  C09K11/06 ,  H10K50/12 ,  H10K85/636 ,  H10K85/6574 ,  H10K85/6576 ,  H10K85/658 ,  C09K2211/1018

摘要： The present invention relates to a novel heterocyclic compound which can be used for an organic light-emitting device, and an organic light-emitting device comprising same, wherein [Chemical Formula A] above is as set forth in the detailed description of the invention.

公开(公告)号：US20240051948A1

公开(公告)日：2024-02-15

申请号：US18486620

申请日：2023-10-13

申请人： Petra Pharma Corporation

发明人： Erin Danielle ANDERSON ,  Sean Douglas ARONOW ,  Nicholas A. BOYLES ,  Surendra DAWADI ,  Eugene R. HICKEY ,  Thomas Combs IRVIN ,  Edward A. KESICKI ,  Gabrielle R. KOLAKOWSKI ,  Jennifer Lynn KNIGHT ,  Manoj KUMAR ,  Katelyn Frances LONG ,  Christopher Glenn MAYNE ,  Alfredo PICADO ,  Gerit Maria POTOTSCHNIG ,  Michael Brian WELCH ,  Tien WIDJAJA ,  Xiaohong CHEN ,  Nathan Edward WRIGHT ,  Hua-Yu WANG

IPC分类号： C07D405/10 ,  A61P35/00 ,  C07D311/30 ,  C07D405/12 ,  C07D407/04 ,  C07D413/10 ,  C07D417/12

CPC分类号： C07D405/10 ,  A61P35/00 ,  C07D311/30 ,  C07D405/12 ,  C07D407/04 ,  C07D413/10 ,  C07D417/12

摘要： The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I):




or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

公开(公告)号：US11834417B2

公开(公告)日：2023-12-05

申请号：US17315969

申请日：2021-05-10

申请人： Vectus Biosystems Limited

发明人： Karen Annette Duggan

IPC分类号： C07D233/64 ,  C07D241/04 ,  A61P9/00 ,  A61P13/12 ,  A61P11/00 ,  C07D233/90 ,  C07D401/06 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D417/04 ,  C07D413/04 ,  C07D413/06 ,  C07D403/06 ,  C07D407/04 ,  C07D417/06 ,  C07D407/06 ,  C07D409/06 ,  C07D409/04 ,  A61P1/16 ,  A61P9/12

CPC分类号： C07D233/64 ,  A61P1/16 ,  A61P9/00 ,  A61P9/12 ,  A61P11/00 ,  A61P13/12 ,  C07D233/90 ,  C07D241/04 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D407/04 ,  C07D407/06 ,  C07D409/04 ,  C07D409/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06

摘要： The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.

公开(公告)号：US11787765B2

公开(公告)日：2023-10-17

申请号：US17516272

申请日：2021-11-01

申请人： FMC CORPORATION

发明人： Andrew Duncan Satterfield ,  Matthew James Campbell ,  James Francis Bereznak ,  William Guy Whittingham ,  Glynn Mitchell ,  Christopher John Mathews ,  James Nicholas Scutt ,  James Alan Morris ,  Jonathan Wesley Paul Dallimore

IPC分类号： C07D211/40 ,  C07D211/94 ,  C07D207/46 ,  C07D401/04 ,  C07D401/12 ,  C07D407/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D471/04 ,  C07D495/04 ,  C07D207/277 ,  A01N43/36 ,  A01N43/40

CPC分类号： C07D211/40 ,  A01N43/36 ,  A01N43/40 ,  C07D207/277 ,  C07D207/46 ,  C07D211/94 ,  C07D401/04 ,  C07D401/12 ,  C07D407/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D471/04 ,  C07D495/04

摘要： Disclosed are compounds of Formula 1, N-oxides of the compounds and salts of the compounds and N-oxides:






wherein R1, R2, R3, R4, R5, R6, Q1, Q2, J, Y1, and Y2 are as defined in the disclosure.




Also disclosed are compositions containing the compounds, N-oxides and salts, and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of such a compound, N-oxide, salt or composition.

公开(公告)号：US11691952B2

公开(公告)日：2023-07-04

申请号：US17787656

申请日：2021-04-28

申请人： Shaanxi Lighte Optoelectronics Material Co., Ltd.

发明人： Min Yang ,  Peng Nan

IPC分类号： C07D251/24 ,  C07D407/04 ,  C07D401/04 ,  C07D401/10 ,  C07D405/10 ,  C07D403/10 ,  C07D403/04 ,  C07D413/10 ,  C07D417/10 ,  C07D239/74 ,  C07D237/08 ,  C07D241/42 ,  C07D215/12 ,  C07D235/18 ,  C07D495/04 ,  C07D491/048 ,  C07D405/14 ,  C07D407/14 ,  C07D401/14 ,  C07D239/26 ,  H01L51/50 ,  H01L51/00 ,  C07D405/04

CPC分类号： C07D251/24 ,  C07D215/12 ,  C07D235/18 ,  C07D237/08 ,  C07D239/26 ,  C07D239/74 ,  C07D241/42 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/10 ,  C07D405/14 ,  C07D407/04 ,  C07D407/14 ,  C07D413/10 ,  C07D417/10 ,  C07D491/048 ,  C07D495/04 ,  H01L51/0064 ,  H01L51/0067 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/0073 ,  H01L51/0074 ,  H01L51/5072 ,  H01L51/5096 ,  C07B2200/05

摘要： The present application relates to a nitrogen-containing compound. The structural formula of the nitrogen-containing compound is as shown in a Formula 1, in which a ring A and a ring B are each independently selected from a benzene ring or a fused aromatic ring with 10 to 14 ring-forming carbon atoms, and at least one of the ring A and the ring B is selected from the fused aromatic ring with 10 to 14 ring-forming carbon atoms; L is selected from a single bond, a substituted or unsubstituted arylene group with 6 to 30 carbon atoms, and a substituted or unsubstituted heteroarylene group with 3 to 30 carbon atoms; and Het is a substituted or unsubstituted nitrogen-containing heteroaryl group with 3 to 30 carbon atoms. The nitrogen-containing compound of the present application can improve the luminous efficiency of an organic electroluminescent device and the conversion efficiency of a photoelectric conversion device using the nitrogen-containing compound.

公开(公告)号：US20230165892A1

公开(公告)日：2023-06-01

申请号：US17983125

申请日：2022-11-08

申请人： SynDevRx, Inc.

发明人： John S. PETERSEN

IPC分类号： A61K31/785 ,  A61K47/58 ,  C07D303/18 ,  C07D405/14 ,  C07D407/04 ,  C07D473/34 ,  C07K7/06 ,  C08F220/58 ,  A61K31/336

CPC分类号： A61K31/785 ,  A61K47/58 ,  C07D303/18 ,  C07D405/14 ,  C07D407/04 ,  C07D473/34 ,  C07K7/06 ,  C08F220/58 ,  A61K31/336

摘要： One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.

公开(公告)号：US11649475B2

公开(公告)日：2023-05-16

申请号：US17058623

申请日：2019-05-24

申请人： NEMIS Technologies AG ,  Ramot at Tel-Aviv University Ltd.

发明人： Doron Shabat ,  Michal Eli Roth-Konforti ,  Nir Hananya ,  Ori Green ,  Urs Spitz ,  Lukas Wick ,  Julian Ihssen ,  Raffael Vorberg ,  Riccardo Cribiu ,  Zuzana Babjakovà ,  Chunyan Yao

IPC分类号： C07D321/00 ,  C07D407/04 ,  C12Q1/10 ,  C12Q1/04 ,  C12Q1/14 ,  C12Q1/22 ,  C12Q1/44 ,  C12Q1/54 ,  G01N21/76

CPC分类号： C12Q1/10 ,  C07D321/00 ,  C07D407/04 ,  C12Q1/04 ,  C12Q1/14 ,  C12Q1/22 ,  C12Q1/44 ,  C12Q1/54 ,  G01N21/76

摘要： Dioxetane compounds represented by Formula I below, and methods of using the dioxetane compounds in the detection of presence or absence, quantification, and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, and fungi by means of chemiluminescence.

公开(公告)号：US20190185443A1

公开(公告)日：2019-06-20

申请号：US16241424

申请日：2019-01-07

申请人： Northeastern University

发明人： Alexandros Makriyannis ,  Ganeshsingh A. Thakur ,  Rishi Sharma

IPC分类号： C07D311/80 ,  C07D493/04 ,  C07C255/57 ,  C07D405/12 ,  C07D407/04 ,  C07C57/58

CPC分类号： C07D311/80 ,  C07C57/58 ,  C07C255/57 ,  C07D405/12 ,  C07D407/04 ,  C07D493/04

摘要： Disclosed are compounds and compositions that modulate cannabinoid receptors, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. This disclosure is directed to methods of treating cannabinoid dependence, neuropathy, inflammation, glaucoma, a neurodegenerative disorder, a motor function disorder, a gastrointestinal disorder, hypothermia, emesis, loss of appetite, or anorexia associated with AIDS.

公开(公告)号：US20180346455A1

公开(公告)日：2018-12-06

申请号：US16008631

申请日：2018-06-14

申请人： Zander Therapeutics, Inc.

发明人： Harry M. Lander ,  David R. Koos

IPC分类号： C07D407/12 ,  C07D407/14 ,  C07D333/48 ,  C07D407/04

CPC分类号： C07D407/12 ,  C07D333/48 ,  C07D407/04 ,  C07D407/14 ,  C07D409/14

摘要： The present technology is directed to modulators of nuclear receptor activity, specifically to the modulation of NR2F6 activity and NR2F6 utilizing compounds, and the immune modulation and modulation of cancer stem cell activity through administration of compounds described herein to animals.