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公开(公告)号：US07576094B2
公开(公告)日：2009-08-18
申请号：US11298137
申请日：2005-12-09
申请人： Daniel T. W. Chu , Jian Chen , Wei Zhang , Xianfeng Li , Jiangao Song , Bing Wang , Qiang Cong , Donald R. James
发明人： Daniel T. W. Chu , Jian Chen , Wei Zhang , Xianfeng Li , Jiangao Song , Bing Wang , Qiang Cong , Donald R. James
IPC分类号： A61K31/353 , A61K31/382 , A61K31/4353 , C07D221/20 , C07D311/96 , C07D335/04
CPC分类号： C07D221/20 , C07D311/96 , C07D335/04 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D407/04 , C07D413/04 , C07D417/04
摘要： The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful in the manufacture of pharmaceutical formulations for the treatment of lipoxygenase-mediated disorders.
摘要翻译： 本发明涉及某些新的螺取代杂环衍生物。 这些化合物可用于制备用于治疗由脂肪氧合酶介导的病症的药物组合物。 它们也可用于制备用于治疗脂氧合酶介导的病症的药物制剂。
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公开(公告)号：US20060128790A1
公开(公告)日：2006-06-15
申请号：US11298137
申请日：2005-12-09
申请人： Daniel Chu , Jian Chen , Wei Zhang , Xianfeng Li , Jiangao Song , Bing Wang , Qiang Cong , Donald James
发明人： Daniel Chu , Jian Chen , Wei Zhang , Xianfeng Li , Jiangao Song , Bing Wang , Qiang Cong , Donald James
IPC分类号： A61K31/382 , A61K31/353 , C07D335/10 , C07D317/72
CPC分类号： C07D221/20 , C07D311/96 , C07D335/04 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D407/04 , C07D413/04 , C07D417/04
摘要： The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful in the manufacture of pharmaceutical formulations for the treatment of lipoxygenase-mediated disorders.
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公开(公告)号：US07514461B2
公开(公告)日：2009-04-07
申请号：US10941125
申请日：2004-09-15
申请人： Bing Wang , Gail Walkinshaw , Sekhar Boddupalli , Arkadij M. Elizarov , Xianming Jin , Xianfeng Li , Donald R. James , Jiangao Song , Jian Chen , Wei Zhang
发明人： Bing Wang , Gail Walkinshaw , Sekhar Boddupalli , Arkadij M. Elizarov , Xianming Jin , Xianfeng Li , Donald R. James , Jiangao Song , Jian Chen , Wei Zhang
IPC分类号： A61K31/355 , A61K31/427 , A61K31/4152 , C07D311/72 , C07D405/06 , C07D417/06
CPC分类号： A61K31/352 , A61K31/353 , A61K31/357 , A61K31/496 , A61K31/675 , A61K31/7048 , C07D295/096 , C07D311/58 , C07D311/70 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12
摘要： The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.
摘要翻译： 本发明涉及式I的新型色满衍生物，立体异构体和药学上可接受的盐，其中取代基如说明书中所定义。 它们可用于治疗由脂氧合酶介导的疾病，例如免疫疾病，呼吸系统疾病和心血管疾病，以及治疗神经变性疾病和/或线粒体疾病。 它们也可用于制备用于治疗这些病症的药物制剂。
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公开(公告)号：US20050065150A1
公开(公告)日：2005-03-24
申请号：US10941125
申请日：2004-09-15
申请人： Bing Wang , Gail Walkinshaw , Sekhar Boddupalli , Arkadij Elizarov , Xianming Jin , Xianfeng Li , Donald James , Jiangao Song , Jian Chen , Wei Zhang
发明人： Bing Wang , Gail Walkinshaw , Sekhar Boddupalli , Arkadij Elizarov , Xianming Jin , Xianfeng Li , Donald James , Jiangao Song , Jian Chen , Wei Zhang
IPC分类号： A61K31/353 , A61K31/675 , A61K31/7048 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12 , A61K31/382 , A61K31/538
CPC分类号： A61K31/352 , A61K31/353 , A61K31/357 , A61K31/496 , A61K31/675 , A61K31/7048 , C07D295/096 , C07D311/58 , C07D311/70 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12
摘要： The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.
摘要翻译： 本发明涉及式I的新型色满衍生物，立体异构体和药学上可接受的盐，其中取代基如说明书中所定义。 它们可用于治疗由脂氧合酶介导的疾病，例如免疫疾病，呼吸系统疾病和心血管疾病，以及治疗神经变性疾病和/或线粒体疾病。 它们也可用于制备用于治疗这些病症的药物制剂。
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公开(公告)号：US20060178356A1
公开(公告)日：2006-08-10
申请号：US11387507
申请日：2006-03-22
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： C07F1/08 , A61K31/555 , A61K31/426 , A61K31/4152 , A61K31/444
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
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公开(公告)号：US07470798B2
公开(公告)日：2008-12-30
申请号：US10941121
申请日：2004-09-15
申请人： Bing Wang , Gail Walkinshaw , Jian Chen , Xianming Jin , Jiangao Song , Wei Zhang
发明人： Bing Wang , Gail Walkinshaw , Jian Chen , Xianming Jin , Jiangao Song , Wei Zhang
IPC分类号： C07D309/00
CPC分类号： A61K31/352 , A61K31/353 , A61K31/357 , A61K31/496 , A61K31/675 , A61K31/7048 , C07D295/096 , C07D311/58 , C07D311/70 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12
摘要： 7,8-Bicyclic-chroman derivatives of Formula I: wherein the substituents are defined as in the specification or the pharmaceutically acceptable salts thereof, are disclosed. They are useful for the treatment of inflammatory disorders, neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.
摘要翻译： 7,8-式I的双环 - 苯并二氢吡喃衍生物：其中取代基如说明书或其药学上可接受的盐所定义。 它们可用于治疗炎性疾病，神经变性疾病和/或线粒体疾病。 它们也可用于制备用于治疗这些病症的药物制剂。
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7.发明申请Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods 审中-公开细胞保护化合物，药物和化妆品制剂及方法公开(公告)号：US20050142155A1
公开(公告)日：2005-06-30
申请号：US11055895
申请日：2005-02-10
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： C07D295/18 , A61K8/00 , A61K8/30 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/122 , A61K31/15 , A61K31/166 , A61K31/18 , A61K31/192 , A61K31/21 , A61K31/235 , A61K31/277 , A61K31/28 , A61K31/30 , A61K31/315 , A61K31/343 , A61K31/353 , A61K31/36 , A61K31/381 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4425 , A61K31/444 , A61K31/4453 , A61K31/5375 , A61K31/555 , A61K31/662 , A61K31/7024 , A61K33/32 , A61P1/04 , A61P3/10 , A61P5/24 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/16 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P29/00 , A61P37/06 , A61P43/00 , A61Q19/00 , A61Q19/02 , C07C39/21 , C07C39/373 , C07C39/44 , C07C43/215 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C49/747 , C07C50/34 , C07C69/007 , C07C69/76 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/15 , C07C255/36 , C07C255/53 , C07C255/54 , C07C311/29 , C07C317/22 , C07D213/30 , C07D213/53 , C07D231/22 , C07D231/26 , C07D233/24 , C07D233/64 , C07D235/08 , C07D277/20 , C07D277/24 , C07D277/30 , C07D277/34 , C07D295/22 , C07D295/26 , C07D307/83 , C07D311/72 , C07D317/62 , C07D333/16 , C07F1/08 , C07F9/40 , C07H13/08 , A61K7/42 , A61K31/4152 , A61K31/42 , C07D231/08 , C07D261/12
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
摘要翻译： 细胞保护性化合物，其中许多是以具有某些缀合键的取代苯酚为特征的酚类衍生物，可用于治疗某些缺血性或炎症性疾病，包括但不限于中风，心肌梗死，充血性心力衰竭和特征为 炎症或氧化损伤。 它们也可用于制造用于治疗这些病症的药物和化妆品制剂。
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公开(公告)号：US20050065149A1
公开(公告)日：2005-03-24
申请号：US10941121
申请日：2004-09-15
申请人： Bing Wang , Gail Walkinshaw , Jian Chen , Xianming Jin , Jiangao Song , Wei Zhang
发明人： Bing Wang , Gail Walkinshaw , Jian Chen , Xianming Jin , Jiangao Song , Wei Zhang
IPC分类号： A61K31/353 , A61K31/675 , A61K31/7048 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12 , A61K31/538 , A61K31/382
CPC分类号： A61K31/352 , A61K31/353 , A61K31/357 , A61K31/496 , A61K31/675 , A61K31/7048 , C07D295/096 , C07D311/58 , C07D311/70 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12
摘要： 7,8-Bicyclic-chroman derivatives of Formula I: wherein the substituents are defined as in the specification or the pharmaceutically acceptable salts thereof, are disclosed. They are useful for the treatment of inflammatory disorders, neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.
摘要翻译： 7,8-式I的双环 - 苯并二氢吡喃衍生物：其中取代基如说明书或其药学上可接受的盐所定义。 它们可用于治疗炎性疾病，神经变性疾病和/或线粒体疾病。 它们也可用于制备用于治疗这些病症的药物制剂。
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9.发明授权Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods 有权细胞保护化合物，药物和化妆品制剂及方法公开(公告)号：US07629375B2
公开(公告)日：2009-12-08
申请号：US11015198
申请日：2004-12-16
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： A61K31/415 , A01N43/56
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
摘要翻译： 细胞保护性化合物，其中许多是以具有某些缀合键的取代苯酚为特征的酚类衍生物，可用于治疗某些缺血性或炎症性疾病，包括但不限于中风，心肌梗死，充血性心力衰竭和特征为 炎症或氧化损伤。 它们也可用于制造用于治疗这些病症的药物和化妆品制剂。
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公开(公告)号：US20050113416A1
公开(公告)日：2005-05-26
申请号：US11015198
申请日：2004-12-16
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： C07D295/18 , A61K8/00 , A61K8/30 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/122 , A61K31/15 , A61K31/166 , A61K31/18 , A61K31/192 , A61K31/21 , A61K31/235 , A61K31/277 , A61K31/28 , A61K31/30 , A61K31/315 , A61K31/343 , A61K31/353 , A61K31/36 , A61K31/381 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4425 , A61K31/444 , A61K31/4453 , A61K31/5375 , A61K31/555 , A61K31/662 , A61K31/7024 , A61K33/32 , A61P1/04 , A61P3/10 , A61P5/24 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/16 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P29/00 , A61P37/06 , A61P43/00 , A61Q19/00 , A61Q19/02 , C07C39/21 , C07C39/373 , C07C39/44 , C07C43/215 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C49/747 , C07C50/34 , C07C69/007 , C07C69/76 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/15 , C07C255/36 , C07C255/53 , C07C255/54 , C07C311/29 , C07C317/22 , C07D213/30 , C07D213/53 , C07D231/22 , C07D231/26 , C07D233/24 , C07D233/64 , C07D235/08 , C07D277/20 , C07D277/24 , C07D277/30 , C07D277/34 , C07D295/22 , C07D295/26 , C07D307/83 , C07D311/72 , C07D317/62 , C07D333/16 , C07F1/08 , C07F9/40 , C07H13/08 , A61K31/445 , A61K31/165 , A61K31/185 , A61K31/40
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
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