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公开(公告)号：US20240302640A1
公开(公告)日：2024-09-12
申请号：US18600728
申请日：2024-03-10
Applicant: Ramona Optics Inc.
Inventor： Gregor Horstmeyer , Robert Horstmeyer , Paul Reamey
CPC classification number: G02B21/18 , G02B21/0028 , G02B21/0032 , G02B21/0076 , H04N23/11 , H04N23/56 , H04N23/74 , H04N23/90
Abstract: An imaging system having multiple cameras can be used for simultaneously imaging the top and side of samples in wells of a wellplate under multiple illumination sources, with each well in the wellplate adjacent to a set of two angled optical elements configured for viewing the two opposite side of the well. The cameras, the wells, and the illumination sources are configured to match each other to provide a high throughput imaging system, which can be used for a wide range of applications including pharmaceutical drug discovery, toxicology and a patient specific oncology.
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公开(公告)号：US11953670B2
公开(公告)日：2024-04-09
申请号：US17546377
申请日：2021-12-09
Applicant: Ramona Optics Inc.
Inventor： Mark Harfouche , Gregor Horstmeyer , Robert Horstmeyer
CPC classification number: G02B21/367 , G02B21/06 , G02B21/368 , H04N23/67
Abstract: An imaging system is configured with an autofocus operation that refocuses multiple cameras of the imaging system on detected features of interest, instead of on the whole image of the sample. Focus measures are calculated on the detected features, and then aggregated to focus distances of actuator moving the camera array, the sample stage, or individual cameras based on a maximization of detected features to be in focus. After the refocus, the imaging system recaptures new images and analyzes features on the new images to generate statistical characterization of the sample based on the classification of the features.
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公开(公告)号：US20240080579A1
公开(公告)日：2024-03-07
申请号：US18508115
申请日：2023-11-13
Applicant: Ramona Optics Inc.
Inventor： Mark HARFOUCHE , Roarke HORSTMEYER , Robert HORSTMEYER
IPC: H04N23/90 , G01B11/245 , H04N23/54 , H04N23/695
CPC classification number: H04N23/90 , G01B11/245 , H04N23/54 , H04N23/695
Abstract: An arrangement of one or more micro cameras are used in conjunction with computer controlled illumination to create a high-throughput microscope able to operate without the need of expensive scanning stages. A single unit contains a plurality of sensors, lenses tiled in such a way to cover a significant fraction of the desired field of view in a digital single acquisition. Mechanical stages and patterned illumination can then be used in conjunction with the system to enhanced the imaged depth of field, or create an acquisition stack to enhance the information acquired. Multiple units can be combined to obtain images of a single sample from different angles. The absence of mechanical stages makes the imaging system ideal for use in scenarios that require the sample to be in a climate and/or environmentally controlled chamber.
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公开(公告)号：US20230058781A1
公开(公告)日：2023-02-23
申请号：US17978078
申请日：2022-10-31
Applicant: Ramona Optics Inc.
Inventor： Jaehee Park , Mark Harfouche , Gregor Horstmeyer , Jed Doman , Paul Reamey
Abstract: A system and method for high resolution multi-fluorescence imaging with synchronized image acquisition amongst sensors can be used to simultaneously capture fluorescence signals from multiple fluorophores over extremely large fields of view. The system can include an array of micro-cameras, along with a particular arrangement of fluorescent filters that can be fixed in one location or moved to new locations.
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公开(公告)号：US20220141393A1
公开(公告)日：2022-05-05
申请号：US17500379
申请日：2021-10-13
Applicant: Ramona Optics Inc.
Inventor： Mark HARFOUCHE , Roarke HORSTMEYER , Robert HORSTMEYER
IPC: H04N5/247 , H04N5/232 , G01B11/245 , H04N5/225
Abstract: An arrangement of one or more micro cameras are used in conjunction with computer controlled illumination to create a high-throughput microscope able to operate without the need of expensive scanning stages. A single unit contains a plurality of sensors, lenses tiled in such a way to cover a significant fraction of the desired field of view in a digital single acquisition. Mechanical stages and patterned illumination can then be used in conjunction with the system to enhanced the imaged depth of field, or create an acquisition stack to enhance the information acquired. Multiple units can be combined to obtain images of a single sample from different angles. The absence of mechanical stages makes the imaging system ideal for use in scenarios that require the sample to be in a climate and/or environmentally controlled chamber.
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Patent Agency Ranking
公开(公告)号：US11818471B2
公开(公告)日：2023-11-14
申请号：US17500379
申请日：2021-10-13
Applicant: Ramona Optics Inc.
Inventor： Mark Harfouche , Roarke Horstmeyer , Robert Horstmeyer
IPC: H04N23/90 , G01B11/245 , H04N23/54 , H04N23/695
CPC classification number: H04N23/90 , G01B11/245 , H04N23/54 , H04N23/695
Abstract: An arrangement of one or more micro cameras are used in conjunction with computer controlled illumination to create a high-throughput microscope able to operate without the need of expensive scanning stages. A single unit contains a plurality of sensors, lenses tiled in such a way to cover a significant fraction of the desired field of view in a digital single acquisition. Mechanical stages and patterned illumination can then be used in conjunction with the system to enhanced the imaged depth of field, or create an acquisition stack to enhance the information acquired. Multiple units can be combined to obtain images of a single sample from different angles. The absence of mechanical stages makes the imaging system ideal for use in scenarios that require the sample to be in a climate and/or environmentally controlled chamber.
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公开(公告)号：US11525997B2
公开(公告)日：2022-12-13
申请号：US17228121
申请日：2021-04-12
Applicant: Ramona Optics Inc.
Inventor： Roarke Horstmeyer , Robert Horstmeyer , Mark Harfouche
Abstract: An array of more than one digital micro-camera, along with the use of patterned illumination and a digital post-processing operation, jointly create a multi-camera patterned illumination (MCPI) microscope. Each micro-camera includes its own unique lens system and detector. The field-over-view of each micro-camera unit at least partially overlaps with the field-of-view of one or more other micro-camera units within the array. The entire field-of-view of a sample of interest is imaged by the entire array of micro-cameras in a single snapshot. In addition, the MCPI system uses patterned optical illumination to improve its effective resolution. The MCPI system captures one or more images as the patterned optical illumination changes its distribution across space and/or angle at the sample. Then, the MCPI system digitally combines the acquired image sequence using a unique post-processing algorithm.
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公开(公告)号：US11477411B1
公开(公告)日：2022-10-18
申请号：US17157928
申请日：2021-01-25
Applicant: Ramona Optics Inc.
Inventor： Mark Harfouche , Jaehee Park , Colin Cooke , Gregor Horstmeyer , Veton Saliu
Abstract: A method to capture microscopy images from multiple image sensors and to relay them to one or more central processing units while minimizing delay in image capture can include the co-optimization of image acquisition hardware, data aggregation digital logic, firmware, and integration with data post processing on the central processing units. The methods can include organizing the incoming image data into data packets containing partial image frames, together with configuring the central processing units to be capable of analyzing the received partial image frames. The quick analysis of the images, e.g., on the partial image frames, can allow the computational system to rapidly respond to the captured images, such as to provide feed back on the captured images before the next images are to be captured.
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公开(公告)号：US11477410B1
公开(公告)日：2022-10-18
申请号：US17157924
申请日：2021-01-25
Applicant: Ramona Optics Inc.
Inventor： Mark Harfouche , Jaehee Park , Colin Cooke , Gregor Horstmeyer , Veton Saliu
Abstract: A method to capture microscopy images from multiple image sensors and to relay them to one or more central processing units while minimizing delay in image capture can include the co-optimization of image acquisition hardware, data aggregation digital logic, firmware, and integration with data post processing on the central processing units. The methods can include organizing the incoming image data into data packets containing partial image frames, together with configuring the central processing units to be capable of analyzing the received partial image frames. The quick analysis of the images, e.g., on the partial image frames, can allow the computational system to rapidly respond to the captured images, such as to provide feed back on the captured images before the next images are to be captured.
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公开(公告)号：US11153508B2
公开(公告)日：2021-10-19
申请号：US16954960
申请日：2018-12-17
Applicant: Ramona Optics Inc.
Inventor： Mark Harfouche , Roarke Horstmeyer , Robert Horstmeyer
IPC: H04N5/247 , H04N5/232 , G01B11/245 , H04N5/225
Abstract: An arrangement of one or more micro cameras are used in conjunction with computer controlled illumination to create a high-throughput microscope able to operate without the need of expensive scanning stages. A single unit contains a plurality of sensors, lenses tiled in such a way to cover a significant fraction of the desired field of view in a digital single acquisition. Mechanical stages and patterned illumination can then be used in conjunction with the system to enhanced the imaged depth of field, or create an acquisition stack to enhance the information acquired. Multiple units can be combined to obtain images of a single sample from different angles. The absence of mechanical stages makes the imaging system ideal for use in scenarios that require the sample to be in a climate and/or environmentally controlled chamber.
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