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公开(公告)号:US20250041603A1
公开(公告)日:2025-02-06
申请号:US18696392
申请日:2022-09-21
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. , Sheba Impact Ltd.
Inventor: Ben Meir MAOZ , Gil MARKOVICH , Amir ARAMI , Iftach SHLOMY
Abstract: Provided herein are devices, systems and methods for restoring tactile sensation in a subject, using a subcutaneously implanted nanogenerator which is connected to at least one of the subject's sensory nerves and is configured to produce an electric signal upon external stimulus and provide the electric signal to the sensory nerve to thereby stimulate the nerve in accordance with the external stimulus.
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公开(公告)号:US20240415644A1
公开(公告)日:2024-12-19
申请号:US18814988
申请日:2024-08-26
Applicant: SHEBA IMPACT LTD.
Inventor: Ehud RAANANI , Boris ORLOV , Boaz HARARI , Oded MEIRI , Lichen ROZITSKY
IPC: A61F2/24
Abstract: Apparatus and methods are described including placing a valve frame within a subject's heart. The valve frame is configured to support the prosthetic valve within the native atrio-ventricular valve and includes a valve frame body having atrial and ventricular parts and at least one arm that is configured to extend from the ventricular part. The arm is deployed among chords of the native atrio-ventricular valve and is rotated, such as to pull the native atrio-ventricular valve radially inward toward the valve frame and twist the native atrio-ventricular valve around the valve frame, by recruiting and deflecting at least a portion of the chords. The frame body of the valve frame traps the native valve leaflets in a partially closed and twisted configuration by radially expanding, to thereby at least partially seal a space between the native atrio-ventricular valve and the prosthetic valve. Other applications are also described.
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公开(公告)号:US20240293026A1
公开(公告)日:2024-09-05
申请号:US18572809
申请日:2022-06-22
Applicant: Sheba Impact Ltd.
Inventor: Abigail LIVNY-EZER , Inbar MENINGHER , Gregory BERLINERBLAU , Reut Moran RAIZMAN
CPC classification number: A61B5/0042 , A61B5/055 , A61B5/7267
Abstract: A method of determining a condition of a subject comprises receiving functional magnetic resonance (MR) data and structural MR data, each describing the brain of the subject. A subject-specific functional connectome (FC) is constructed using the functional MR data, and a subject-specific structural connectome (SC) is constructed using the structural MR data. A convolutional neural network (CNN) is fed with the subject-specific FC and SC. The CNN has a first set of layers that separately process the subject-specific FC and SC, and a second set of layers that process combined outputs from the first set of layers. An output indicative of the condition of the subject is received from the second set of layers of the CNN.
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公开(公告)号:US20240261256A1
公开(公告)日:2024-08-08
申请号:US18101611
申请日:2023-01-26
Applicant: Sheba Impact Ltd. , Ministry of Health, State of Israel
Inventor: Yaacov DAVIDOV , Galia RAHAV , Alla USYSKIN-TONNE , Alex SHULMAN , Ari ROBINSON , Israel Ronen NISSAN , Noa Lea TEJMAN-YARDEN
IPC: A61K31/357 , A61K31/4025 , A61K31/4433 , A61K33/24 , A61P31/04
CPC classification number: A61K31/357 , A61K31/4025 , A61K31/4433 , A61K33/24 , A61P31/04
Abstract: A method of treating an infection of a gram positive bacteria in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of enterobactin and/or an active derivative thereof. Compositions comprising enterobactin are also disclosed or active derivatives are also disclosed.
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公开(公告)号:US20240120101A1
公开(公告)日:2024-04-11
申请号:US18509835
申请日:2023-11-15
Applicant: SHEBA IMPACT LTD.
Inventor: Yael HABERMAN ZIV , Haya ABBAS , Tzipi BRAUN , Amnon AMIR
Abstract: Herein disclosed are a computer-implemented method, a system, and a kit for assessing/classifying the health status associated with a microbiome profile of a gastrointestinal (GI) sample. The method includes receiving data regarding expression levels of amplicon sequence variants (ASVs) of a V4 region of 16S rRNA in a GI sample of a subject, and utilizing a machine learning algorithm that is trained to distinguish a healthy state from a sick state, a score is computed, and a prediction is made for the presence of a general microbial response that is shared by a large variety of diseases.
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公开(公告)号:US20250120805A1
公开(公告)日:2025-04-17
申请号:US18999207
申请日:2024-12-23
Applicant: SHEBA IMPACT LTD.
Inventor: Boris Orlov , Ehud Raanani
Abstract: Apparatus and methods are described herein including an expandable prosthetic mitral valve device that includes a first component configured to be deployed in the left atrium of a subject and a second component configured to be deployed in a left ventricle of the subject. At least one approximating component approximates the first and second components with respect to each other, such that, when the first and said second components are in an approximated configuration with respect to each other, one or more leaflets of the native mitral valve are trapped within the gap between a ventricular part and an annulus part. The approximating component secures the annulus part and the ventricular part in the approximated configuration. Other applications are also described.
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公开(公告)号:US20240271135A1
公开(公告)日:2024-08-15
申请号:US18442518
申请日:2024-02-15
Applicant: SHEBA IMPACT LTD.
Inventor: Yehuda KAMARI , Michal KANDEL-KFIR , Dror HARATS , Dan DOMINISSINI , Gideon RECHAVI , Aviv SHAISH
IPC: C12N15/113 , A61K45/06 , A61P3/06
CPC classification number: C12N15/113 , A61K45/06 , A61P3/06 , C12N2310/11 , C12N2310/351
Abstract: This disclosure is directed to compositions comprising an RNA therapeutic targeting FAT10 and uses of same.
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公开(公告)号:US20250073292A1
公开(公告)日:2025-03-06
申请号:US18293996
申请日:2022-08-02
Applicant: THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL R , SHEBA IMPACT LTD.
Inventor: Sigal LIRAZ ZALTSMAN , Anat ELMANN , Nativ DUDAI
IPC: A61K36/185 , A61K31/045 , A61P25/00 , A61P25/28
Abstract: The present invention provides methods and compositions comprising essential oil extracted from Pelargonium graveolens for treating, preventing, or ameliorating traumatic brain injury (TBI) in a subject, or for improving cognitive functions in a subject suffering from TBI.
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公开(公告)号:US20240261257A1
公开(公告)日:2024-08-08
申请号:US18408663
申请日:2024-01-10
Applicant: Sheba Impact Ltd. , Ministry of Health, State of Israel
Inventor: Yaacov DAVIDOV , Galia RAHAV , Alla USYSKIN-TONNE , Alex SHULMAN , Ari ROBINSON , Israel Ronen NISSAN , Noa Lea TEJMAN-YARDEN
IPC: A61K31/357 , A61K31/4025 , A61K31/4433 , A61K33/24 , A61P31/04
CPC classification number: A61K31/357 , A61K31/4025 , A61K31/4433 , A61K33/24 , A61P31/04
Abstract: A method of treating an infection of a gram positive bacteria in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of enterobactin and/or an active derivative thereof. Compositions comprising enterobactin are also disclosed or active derivatives are also disclosed.
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公开(公告)号:US20240249409A1
公开(公告)日:2024-07-25
申请号:US18561749
申请日:2022-05-18
Applicant: Ramot at Tel-Aviv University Ltd. , Sheba Impact Ltd.
Inventor: Arnaldo MAYER , Tamir MANOR , Asaf HALLE , Nahum KIRYATI , Eliahu KONEN , Jana PICKOVSKY
CPC classification number: G06T7/0012 , G06T7/11 , G06T2207/10081 , G06T2207/20081 , G06T2207/20084 , G06T2207/30028
Abstract: A method of analyzing an abdominal computed tomography (CT) scan comprises applying a colon segmentation machine learning procedure to the CT scan, and receiving from the colon segmentation machine learning procedure an output indicative of a plurality of colon segments. The method also comprises feeding the output into a colon lesion detection machine learning procedure, and receiving from the colon lesion detection machine learning procedure an output indicative of presence of at least one pathology in the colon.
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