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公开(公告)号：US20070053998A1
公开(公告)日：2007-03-08
申请号：US11219503
申请日：2005-09-02
Applicant: Wen-Chin Yang , Shu-Lin Chang , Lee-Tian Chang , Yi-Ming Chiang , Lie-Fen Shyur
Inventor： Wen-Chin Yang , Shu-Lin Chang , Lee-Tian Chang , Yi-Ming Chiang , Lie-Fen Shyur
IPC: A61K36/185
Abstract: A compound of the formula: wherein R1 is H, alkyl, aryl, or cyclyl; R2 is pyranose; R3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; and p is 1, 2, 3, or 4. Also disclosed is use of the compound to inhibit Th1 differentiation, promote Th2 differentiation, and treat certain disorders.
Abstract translation: 下式的化合物：其中R 1是H，烷基，芳基或环基; R 2是吡喃糖; R 3是H或烷基; m为2,3,4,5或6; n为0,1,2或3; o是0，1，2，3，4; 并且p是1,2,3或4.还公开了该化合物用于抑制Th1分化，促进Th2分化和治疗某些疾病的用途。
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公开(公告)号：US07341752B2
公开(公告)日：2008-03-11
申请号：US11215765
申请日：2005-08-30
Applicant: Wen-Chin Yang , Shu-Lin Chang
Inventor： Wen-Chin Yang , Shu-Lin Chang
CPC classification number: A61K36/28 , A61K31/7048 , Y02A50/478 , A61K2300/00
Abstract: A method for treating a bacterial infection in a subject by administration of an effective amount of centaurein alone or in combination with a bacteriocide. Also described is a composition containing an effective combined amount of centaurein and a bacteriocide useful for treating a bacterial infection in a subject.
Abstract translation: 通过单独施用有效量的百吗百醇或与杀细菌剂组合来治疗受试者的细菌感染的方法。 还描述了含有有效组合量的百里灵素和可用于治疗受试者细菌感染的杀菌剂的组合物。
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Patent Agency Ranking
公开(公告)号：US20070048394A1
公开(公告)日：2007-03-01
申请号：US11215568
申请日：2005-08-29
Applicant: Wen-Chin Yang , Shu-Lin Chang , Yi-Ming Chiang , Lie-Fen Shyur
Inventor： Wen-Chin Yang , Shu-Lin Chang , Yi-Ming Chiang , Lie-Fen Shyur
CPC classification number: G01N33/505 , A61K36/28
Abstract: Methods useful, for example, in identifying plant compositions that have immunomodulatory activity. Also disclosed is an Asteraceae plant immunomodulatory composition useful for increasing an immune response, e.g., IFN γ or IL-2 transcription.
Abstract translation: 方法可用于例如鉴定具有免疫调节活性的植物组合物。 还公开了可用于增加免疫应答例如IFNγ或IL-2转录的菊科植物免疫调节组合物。
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公开(公告)号：US20090062216A1
公开(公告)日：2009-03-05
申请号：US12263896
申请日：2008-11-03
Applicant: Wen-Chin Yang , Shu-Lin Chang , Lee-Tian Chang , Yi-Ming Chiang , Lie-Fen Shyur
Inventor： Wen-Chin Yang , Shu-Lin Chang , Lee-Tian Chang , Yi-Ming Chiang , Lie-Fen Shyur
IPC: A61K31/7028 , A61P37/00
Abstract: A method of treating a Th1-mediated disorder includes administering to a subject in need of the treatment an effective amount of a compound of the formula I: wherein R1 is H, alkyl, aryl, or cyclyl; R2 is pyranose; R3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; p is 1, 2, 3, or 4; and the Th1-mediated disorder is non-obese diabetes, Crohn's colitis, autoimmune hemolytic anemia, rheumatoid arthritis, autoimmune encephalitis, multiple sclerosis, or autoimmune myocarditis. Also disclosed is a pharmaceutical composition including a compound of formula I above and a pharmaceutically acceptable carrier.
Abstract translation: 治疗Th1介导的病症的方法包括向需要治疗的受试者施用有效量的式I化合物：其中R 1是H，烷基，芳基或环基; R2是吡喃糖; R3是H或烷基; m为2,3,4,5或6; n为0,1,2或3; o是0，1，2，3，4; p是1,2,3或4; 并且Th1介导的病症是非肥胖性糖尿病，克罗恩病的结肠炎，自身免疫性溶血性贫血，类风湿性关节炎，自身免疫性脑炎，多发性硬化或自身免疫性心肌炎。 还公开了包含上述式I化合物和药学上可接受的载体的药物组合物。
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公开(公告)号：US20070048395A1
公开(公告)日：2007-03-01
申请号：US11215765
申请日：2005-08-30
Applicant: Wen-Chin Yang , Shu-Lin Chang
Inventor： Wen-Chin Yang , Shu-Lin Chang
IPC: A61K36/28 , A61K31/7048
CPC classification number: A61K36/28 , A61K31/7048 , Y02A50/478 , A61K2300/00
Abstract: A method for treating a bacterial infection in a subject by administration of an effective amount of centaurein alone or in combination with a bacteriocide. Also described is a composition containing an effective combined amount of centaurein and a bacteriocide useful for treating a bacterial infection in a subject.
Abstract translation: 通过单独施用有效量的百吗百醇或与杀细菌剂组合来治疗受试者的细菌感染的方法。 还描述了含有有效组合量的百里灵素和可用于治疗受试者细菌感染的杀菌剂的组合物。
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公开(公告)号：US08048860B2
公开(公告)日：2011-11-01
申请号：US12263896
申请日：2008-11-03
Applicant: Wen-Chin Yang , Shu-Lin Chang , Lee-Tian Chang , Yi-Ming Chiang , Lie-Fen Shyur
Inventor： Wen-Chin Yang , Shu-Lin Chang , Lee-Tian Chang , Yi-Ming Chiang , Lie-Fen Shyur
IPC: A61K31/7032 , C07G3/00 , C07H15/10
Abstract: A method of treating a Th1-mediated disorder includes administering to a subject in need of the treatment an effective amount of a compound of the formula I: wherein R1 is H, alkyl, aryl, or cyclyl; R2 is pyranose; R3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; p is 1, 2, 3, or 4; and the Th1-mediated disorder is non-obese diabetes, Crohn's colitis, autoimmune hemolytic anemia, rheumatoid arthritis, autoimmune encephalitis, multiple sclerosis, or autoimmune myocarditis. Also disclosed is a pharmaceutical composition including a compound of formula I above and a pharmaceutically acceptable carrier.
Abstract translation: 治疗Th1介导的病症的方法包括向需要治疗的受试者施用有效量的式I化合物：其中R 1是H，烷基，芳基或环基; R2是吡喃糖; R3是H或烷基; m为2,3,4,5或6; n为0,1,2或3; o是0，1，2，3，4; p是1,2,3或4; 并且Th1介导的病症是非肥胖性糖尿病，克罗恩病的结肠炎，自身免疫性溶血性贫血，类风湿性关节炎，自身免疫性脑炎，多发性硬化或自身免疫性心肌炎。 还公开了包含上述式I化合物和药学上可接受的载体的药物组合物。
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公开(公告)号：US07691575B2
公开(公告)日：2010-04-06
申请号：US11215568
申请日：2005-08-29
Applicant: Wen-Chin Yang , Shu-Lin Chang , Yi-Ming Chiang , Lie-Fen Shyur
Inventor： Wen-Chin Yang , Shu-Lin Chang , Yi-Ming Chiang , Lie-Fen Shyur
CPC classification number: G01N33/505 , A61K36/28
Abstract: Methods useful, for example, in identifying plant compositions that have immunomodulatory activity. Also disclosed is an Asteraceae plant immunomodulatory composition useful for increasing an immune response, e.g., IFN γ or IL-2 transcription.
Abstract translation: 方法可用于例如鉴定具有免疫调节活性的植物组合物。 还公开了可用于增加免疫应答例如IFNγ或IL-2转录的菊科植物免疫调节组合物。
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