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公开(公告)号:US06258937B1
公开(公告)日:2001-07-10
申请号:US09361707
申请日:1999-07-27
申请人: Shuping Tong , Jisu Li , Jack R. Wands
发明人: Shuping Tong , Jisu Li , Jack R. Wands
IPC分类号: C07K1400
CPC分类号: C07K14/705 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要: The invention features an hepadnavirus cellular receptor and a nucleic acid sequence that encodes the receptor. The receptor is a 170 kD surface glycoprotein, and is referred to as the p170 receptor.
摘要翻译: 本发明的特征在于肝炎疫苗细胞受体和编码受体的核酸序列。 受体是170kD的表面糖蛋白,被称为p170受体。
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公开(公告)号:US5929220A
公开(公告)日:1999-07-27
申请号:US683262
申请日:1996-07-18
申请人: Shuping Tong , Jisu Li , Jack R. Wands
发明人: Shuping Tong , Jisu Li , Jack R. Wands
IPC分类号: A01K67/027 , A61K31/00 , A61K38/00 , A61K39/29 , A61K39/395 , A61K48/00 , A61P31/00 , A61P31/20 , A61P37/00 , C07K14/705 , C07K16/28 , C12N15/09 , C07H21/00 , C07H21/04 , C12N15/10
CPC分类号: C07K14/705 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要: The invention features a purified nucleic acid that encodes a member of the hepadnavirus family of cellular receptors. The receptor is a 170 kD cell surface glycoprotein, and is referred to as the p170 receptor. The pre-S domain of the duck hepatitis B virus envelope protein binds the p170 receptor at a major neutralizing epitope, within which are two basic amino acids required for virion-receptor interaction.
摘要翻译: 本发明的特征在于一种纯化的核酸,其编码细胞受体的肝炎病毒家族的成员。 受体是170kD的细胞表面糖蛋白,被称为p170受体。 鸭乙型肝炎病毒包膜蛋白的前S结构域以主要中和表位结合p170受体,其中是病毒 - 受体相互作用所需的两种碱性氨基酸。
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