公开(公告)号：US07005508B2

公开(公告)日：2006-02-28

申请号：US10362811

申请日：2001-08-10

申请人： Francesca Benedini ,  Benito Casu ,  Piero Del Soldato ,  Paolo Gresele ,  Annamaria Naggi ,  Giangiacomo Torri ,  Simona Venturini

发明人： Francesca Benedini ,  Benito Casu ,  Piero Del Soldato ,  Paolo Gresele ,  Annamaria Naggi ,  Giangiacomo Torri ,  Simona Venturini

IPC分类号： C07H5/04 ,  C07H1/00 ,  C08B37/08 ,  C08B37/10 ,  A61K31/727

CPC分类号： C08B37/0075 ,  C08B37/0063

摘要： The present invention provides a new class of compounds presenting a high compatibility with tissues and organic fluids. Such new compounds are polysaccharides essentially formed of units of uronic acid and/or hexosamine, containing nitro groups —ONO2 covalently bonded to the saccharide structure. Preferably, the polysaccharides according to the invention are prevalently formed of disaccharide repeating units formed of uronic acid and hexosamine. These compounds, in psychological conditions, selectively release NO, allowing a reduction in the amount of NO needed to achieve a determined therapeutical effect. This result has been achieved by functionalizing polysaccharides essentially formed of units of uronic acid and/or hexosamine, with subsituents containing a ONO2 ? group.

摘要翻译： 本发明提供了与组织和有机流体具有高相容性的新类化合物。 这些新化合物是基本上由糖醛酸和/或己糖胺的单元形成的多糖，其含有与糖结构共价结合的硝基-ONO 2。 优选地，根据本发明的多糖优选由由糖醛酸和己糖胺形成的二糖重复单元形成。 这些化合物在心理条件下选择性地释放NO，允许减少实现确定的治疗效果所需的NO量。 通过官能化基本上由糖醛酸和/或己糖胺形成的多糖来实现该结果，其中含有ONO的取代基包含ONO 2？ 组。