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公开(公告)号：US08212024B2
公开(公告)日：2012-07-03
申请号：US12089821
申请日：2006-10-12
申请人： Udayampalayam Palanisamy Senthilkumar , Kanagaraj Suresh Kumar , Singaravel Mohan , Lakshminarayanan Arunkumar , Bakthavachalam Ananthan
发明人： Udayampalayam Palanisamy Senthilkumar , Kanagaraj Suresh Kumar , Singaravel Mohan , Lakshminarayanan Arunkumar , Bakthavachalam Ananthan
IPC分类号： C07D501/36 , A61K31/546
CPC分类号： C07D501/36
摘要： The present invention relates to novel polymorph of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of crystalline Ceftiofur sodium of formula (I).
摘要翻译： 本发明涉及头孢噻呋钠作为结晶产物的新型多晶型物。 本发明还提供了制备式（I）的结晶头孢噻呋钠的方法。
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2.发明授权Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer 失效富含（S，S） - 异构体的S-腺苷-L-甲硫氨酸的化学合成公开(公告)号：US07667034B2
公开(公告)日：2010-02-23
申请号：US11630622
申请日：2005-06-22
申请人： Udayampalayam Palanisamy Senthilkumar , Ramar Padmanabhan , Venugopal Sivasankaran , Singaravel Mohan
发明人： Udayampalayam Palanisamy Senthilkumar , Ramar Padmanabhan , Venugopal Sivasankaran , Singaravel Mohan
IPC分类号： C07H19/16
CPC分类号： C07H19/16
摘要： This invention relates to an improved process for the industrial manufacture of S-adenosyl-L-methionine (SAMe) of formula (I), which consists of stereo-selective methylation of S-adenosyl-L-homocysteine (SAH) with the enrichment of active (S,S)-isomer.
摘要翻译： 本发明涉及一种工业制备式（I）的S-腺苷-L-甲硫氨酸（SAMe）的改进方法，其由S-腺苷-L-高半胱氨酸（SAH）的立体选择性甲基化与富集 活性（S，S） - 异构体。
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3.发明申请Chemical Synthesis Of S-Adenosyl-L-Methionine With Enrichment Of (S,S)-Isomer 失效富含（S，S） - 异构体的S-腺苷-L-甲硫氨酸的化学合成公开(公告)号：US20080103303A1
公开(公告)日：2008-05-01
申请号：US11630622
申请日：2005-06-22
申请人： Udayampalayam Palanisamy Senthilkumar , Ramar Padmanabhan , Venugopal Sivasankaran , Singaravel Mohan
发明人： Udayampalayam Palanisamy Senthilkumar , Ramar Padmanabhan , Venugopal Sivasankaran , Singaravel Mohan
IPC分类号： C07D473/00 , C07C41/00
CPC分类号： C07H19/16
摘要： This invention relates to an improved process for the industrial manufacture of S-adenosyl-L-methionine (SAMe) of formula (I), which consists of stereo-selective methylation of S-adenosyl-L-homocysteine (SAH) with the enrichment of active (S,S)-isomer.
摘要翻译： 本发明涉及一种工业制备式（I）的S-腺苷-L-甲硫氨酸（SAMe）的改进方法，其由S-腺苷-L-高半胱氨酸（SAH）的立体选择性甲基化与富集 活性（S，S） - 异构体。
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公开(公告)号：US20060094872A1
公开(公告)日：2006-05-04
申请号：US11294410
申请日：2005-12-06
申请人： Udayampalayam Senthilkumar , Kanagaraj Sureshkumar , Singaravel Mohan , Lakshminarayanan Arunkumar , Bakthavachalam Ananthan
发明人： Udayampalayam Senthilkumar , Kanagaraj Sureshkumar , Singaravel Mohan , Lakshminarayanan Arunkumar , Bakthavachalam Ananthan
IPC分类号： C07D501/00
CPC分类号： C07D501/00
摘要： An improved process for the preparation of Ceftiofar sodium of formula (I) without isolating intermediate compound of formula (IV)
摘要翻译： 制备式（I）头孢曲南钠的改进方法而不分离式（IV）的中间体化合物，
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公开(公告)号：US20060058281A1
公开(公告)日：2006-03-16
申请号：US11240382
申请日：2005-10-03
申请人： Udayampalayam Senthilkumar , Kanagaraj Sureshkumar , Singaravel Mohan , Lakshminarayanan Arunkumar
发明人： Udayampalayam Senthilkumar , Kanagaraj Sureshkumar , Singaravel Mohan , Lakshminarayanan Arunkumar
IPC分类号： A61K31/545 , C07D501/14
CPC分类号： C07D501/00
摘要： An improved one-pot process for the preparation of Ceftiofur of the formula (I) or its salt, without isolating intermediate compound.
摘要翻译： 用于制备式（I）的头孢噻呋或其盐的改进的一锅法，而不分离中间体化合物。
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6.发明申请Improved Process For the Preparation of Cephalosporin Antibiotic Intermediate 审中-公开改进制备头孢菌素抗生素中间体的方法公开(公告)号：US20100261897A1
公开(公告)日：2010-10-14
申请号：US11794735
申请日：2006-01-16
IPC分类号： C07D501/18
CPC分类号： C07D501/18 , C07D501/04
摘要： The present invention relates to a process for the production of cephalosporin antibiotic intermediate of formula (I). More particularly relates to the preparation of the compound of formula (I) using a solvent medium selected from the group consisting of decalin (decahydronapthalene), hexane, cyclohexene, tetralin, petroleum ether, wherein X represents HI, HCI, H2SO4 and the like. The compound of formula (I) is an important intermediate in the preparation of Cefepime.
摘要翻译： 本发明涉及制备式（I）的头孢菌素抗生素中间体的方法。 更具体地涉及使用选自十氢萘（十氢萘），己烷，环己烯，四氢化萘，石油醚，其中X代表HI，HCl，H 2 SO 4等的溶剂介质制备式（I）化合物。 式（I）化合物是头孢吡肟制剂中的重要中间体。
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公开(公告)号：US20080221076A1
公开(公告)日：2008-09-11
申请号：US12089821
申请日：2006-10-12
申请人： Udayampalayam Palanisamy Senthilkumar , Kanagaraj Suresh Kumar , Singaravel Mohan , Lakshminarayanan Arunkumar , Bakthavachalam Ananthan
发明人： Udayampalayam Palanisamy Senthilkumar , Kanagaraj Suresh Kumar , Singaravel Mohan , Lakshminarayanan Arunkumar , Bakthavachalam Ananthan
IPC分类号： A61K31/546 , C07D501/02 , C07D501/16 , A61P31/00
CPC分类号： C07D501/36
摘要： The present invention relates to novel polymorph of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of crystalline Ceftiofur sodium of formula (I).
摘要翻译： 本发明涉及头孢噻呋钠作为结晶产物的新型多晶型物。 本发明还提供了制备式（I）的结晶头孢噻呋钠的方法。
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公开(公告)号：US07345169B2
公开(公告)日：2008-03-18
申请号：US11240382
申请日：2005-10-03
申请人： Udayampalayam P. Senthilkumar , Kanagaraj Sureshkumar , Singaravel Mohan , Lakshminarayanan Arunkumar
发明人： Udayampalayam P. Senthilkumar , Kanagaraj Sureshkumar , Singaravel Mohan , Lakshminarayanan Arunkumar
IPC分类号： C07D501/36
CPC分类号： C07D501/00
摘要： An improved one-pot process for the preparation of Ceftiofur of the formula (I) or its salt, without isolating intermediate compound
摘要翻译： 用于制备式（I）的头孢噻呋或其盐的改进的一锅法，而不分离中间体化合物
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