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公开(公告)号：US06395740B1
公开(公告)日：2002-05-28
申请号：US09616695
申请日：2000-07-14
申请人： Nand Baindur , Virender Labroo , Steven Stroop , Stephanie Beigel , Theresa Martinez , Charles R. Petrie , Mark W. Orme , Patricia A. Mckernan , Emma E. Moore
发明人： Nand Baindur , Virender Labroo , Steven Stroop , Stephanie Beigel , Theresa Martinez , Charles R. Petrie , Mark W. Orme , Patricia A. Mckernan , Emma E. Moore
IPC分类号： A61K31495
CPC分类号： C07D295/096 , A61K31/495 , C07D295/215
摘要： Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.
摘要翻译： 描述了作为降钙素模拟物的化合物。 这些化合物可用于治疗与骨吸收相关的疾病。 本发明的降钙素模拟物中包括取代的哌嗪。 本发明的降钙素模拟物也可用于文库和用于测定降钙素受体活性的测定中。
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公开(公告)号：US07294613B2
公开(公告)日：2007-11-13
申请号：US10091166
申请日：2002-03-05
CPC分类号： C07K14/4723 , A61K38/00 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the β-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
摘要翻译： 本发明涉及zamp1的多核苷酸和多肽分子，其是β-防御素家族的新成员。 多肽和编码它们的多核苷酸表现出抗微生物活性，并可用于微生物感染的研究或治疗。 本发明还包括针对zamp1多肽的抗体。
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公开(公告)号：US5698672A
公开(公告)日：1997-12-16
申请号：US416601
申请日：1995-04-04
CPC分类号： C07K14/585 , A61K38/00
摘要： The invention provides synthetic calcitonin mimetics. The mimetics of the present invention may include modifications that further enhance desired characteristics, such as oral bioavailability, while maintaining or enhancing inhibition of bone resorption. Related pharmaceutical compositions and methods are also disclosed.
摘要翻译： 本发明提供合成降钙素模拟物。 本发明的模拟物可以包括进一步增强期望特征的修饰，例如口服生物利用度，同时保持或增强对骨吸收的抑制。 还公开了相关的药物组合物和方法。
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公开(公告)号：US06576755B1
公开(公告)日：2003-06-10
申请号：US09636399
申请日：2000-08-10
IPC分类号： C12N1512
CPC分类号： C07K14/4723 , A61K38/00 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the &bgr;-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
摘要翻译： 本发明涉及zamp1的多核苷酸和多肽分子，其是β-防御素家族的新成员。 多肽和编码它们的多核苷酸表现出抗微生物活性，并可用于微生物感染的研究或治疗。 本发明还包括针对zamp1多肽的抗体。
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公开(公告)号：US20060223987A1
公开(公告)日：2006-10-05
申请号：US11450178
申请日：2006-06-09
CPC分类号： C07K14/4723 , A61K38/00 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the β-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
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公开(公告)号：US07087407B2
公开(公告)日：2006-08-08
申请号：US10409532
申请日：2003-04-07
CPC分类号： C07K14/4723 , A61K38/00 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the β-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
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公开(公告)号：US6124299A
公开(公告)日：2000-09-26
申请号：US28085
申请日：1998-02-23
申请人： Nand Baindur , Virender Labroo , Steven Stroop , Stephanie Beigel , Theresa Martinez , Charles R. Petrie , Mark W. Orme , Patricia A. McKernan , Emma E. Moore
发明人： Nand Baindur , Virender Labroo , Steven Stroop , Stephanie Beigel , Theresa Martinez , Charles R. Petrie , Mark W. Orme , Patricia A. McKernan , Emma E. Moore
IPC分类号： C07D295/08 , A61K31/495 , A61P19/08 , A61P19/10 , A61P43/00 , C07D295/096 , C07D295/20 , C07D295/215 , A61K31/415 , A61K31/55
CPC分类号： C07D295/096 , A61K31/495 , C07D295/215
摘要： Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.
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公开(公告)号：US20080160037A1
公开(公告)日：2008-07-03
申请号：US11764048
申请日：2007-06-15
CPC分类号： C07K14/4723 , A61K38/00 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the β-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
摘要翻译： 本发明涉及zamp1的多核苷酸和多肽分子，其是β-防御素家族的新成员。 多肽和编码它们的多核苷酸表现出抗微生物活性，并可用于微生物感染的研究或治疗。 本发明还包括针对zamp1多肽的抗体。
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