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公开(公告)号：US09107412B2
公开(公告)日：2015-08-18
申请号：US13812304
申请日：2011-09-01
Applicant: Jeffrey Keith Long , Vann Gregory , Steven Gutteridge , Andrew Edmund Taggi , James Francis Bereznak
Inventor： Jeffrey Keith Long , Vann Gregory , Steven Gutteridge , Andrew Edmund Taggi , James Francis Bereznak
IPC: A01N43/56 , A01N43/48 , A01N43/40 , A01N43/42 , A01N43/50 , A01N43/54 , A01N43/653 , A01N43/78 , A01N43/84 , A01N43/90 , A01N59/20 , C07D231/38
CPC classification number: A01N43/56 , A01N37/34 , A01N37/44 , A01N43/12 , A01N43/26 , A01N43/30 , A01N43/40 , A01N43/42 , A01N43/48 , A01N43/50 , A01N43/54 , A01N43/653 , A01N43/78 , A01N43/80 , A01N43/84 , A01N43/90 , A01N47/08 , A01N47/12 , A01N47/28 , A01N59/20 , C07D231/20 , C07D231/38 , A01N37/38 , A01N37/46 , A01N43/36 , A01N45/02 , A01N47/04 , A01N47/14 , A01N47/24 , A01N47/34 , A01N47/38
Abstract: Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1, N-oxides, and salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined in the disclosure; and (b) at least one additional fungicidal compound. Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of Formula 1, an N-oxide, or salt thereof (e.g., as a component in the aforesaid composition). Also disclosed is a composition comprising: (a) at least one compound selected from the compounds of Formula 1 described above, N-oxides, and salts thereof; and at least one invertebrate pest control compound or agent.
Abstract translation: 公开了一种杀真菌组合物，其包含（a）至少一种选自式1化合物，N-氧化物及其盐的化合物，其中R 1，R 2，R 3，R 4，R 5和R 6如本公开所定义; 和（b）至少一种另外的杀真菌化合物。 还公开了一种用于控制由真菌植物病原体引起的植物病害的方法，包括向植物或其部分或植物种子施用杀真菌有效量的式1，N-氧化物或其盐的化合物（例如 ，作为上述组合物中的组分）。 还公开了一种组合物，其包含：（a）至少一种选自上述式1的化合物，N-氧化物及其盐的化合物; 和至少一种无脊椎害虫防治化合物或药剂。
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公开(公告)号：US20070105098A1
公开(公告)日：2007-05-10
申请号：US10528611
申请日：2003-09-23
Applicant: Steven Gutteridge , Timothy Caspar , Daniel Cordova , James Rauh , Rejane Smith , Lihong Wu , Yong Tao
Inventor： Steven Gutteridge , Timothy Caspar , Daniel Cordova , James Rauh , Rejane Smith , Lihong Wu , Yong Tao
CPC classification number: C07K14/43563 , C07K14/705
Abstract: The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis virescens), homopteran green peach aphid (Myzus persicae), corn plant hopper (Peregrinus maidis), cotton melon aphid (Aphis gossypii) and fruitfly (Drosophila melanogaster). The full-length genes have been isolated, cloned and amplified in bacterial cells. Expression in insect cells shows that the recombinant protein folds into a functional calcium release channel. The genes and their corresponding polypeptides have a number of uses including, but not limited to, the isolation of other pest ryanodine receptors, the development of screens to identify insecticidally active compounds, use of fragments of genes as pesticides, fragments of protein for antibody production, fragments of protein for determination of the structure of insecticide binding sites, and identification of insecticides that disrupt the calcium balance in cells through other messengers that interact with the receptor calcium release mechanism. Methods are outlined for overcoming toxic effects of expressing recombinant proteins in host cells.
Abstract translation: 编码兰诺定受体同系物的基因已经被多种昆虫家族表征，包括鳞翅目叶烟芽夜蛾（Heliothis virescens），同翅目绿桃蚜虫（Myzus persicae），玉米植物漏斗（Peregrinus maidis），棉花蚜虫（Aphis gossypii）和果蝇 黑腹果蝇）。 全长基因已经在细菌细胞中被分离，克隆和扩增。 昆虫细胞中的表达显示重组蛋白折叠成功能性钙释放通道。 基因及其相应的多肽具有许多用途，包括但不限于分离其它害虫兰诺定受体，筛选鉴定杀虫活性化合物，使用基因片段作为农药，蛋白质片段用于抗体生产 ，用于测定杀虫剂结合位点结构的蛋白质片段，以及鉴定通过与受体钙释放机制相互作用的其他信使破坏细胞中钙平衡的杀虫剂。 概述了克服在宿主细胞中表达重组蛋白的毒性作用的方法。
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公开(公告)号：US20120276554A1
公开(公告)日：2012-11-01
申请号：US13347091
申请日：2012-01-10
Applicant: Steven Gutteridge , Timothy Caspar , Daniel Cordova , James J. Rauh , Yong Tao , Lihong Wu , Rejane M. Smith
Inventor： Steven Gutteridge , Timothy Caspar , Daniel Cordova , James J. Rauh , Yong Tao , Lihong Wu , Rejane M. Smith
CPC classification number: C07K14/43563 , C07K14/705
Abstract: The genes encoding ryanodine receptor homologs have been characterized from multiple insect families. The genes and their corresponding polypeptides have a number of uses including but not limited to the development of screens to identify insecticidally active compounds. Methods are outlined for overcoming toxic effects of expressing recombinant proteins in host cells.
Abstract translation: 编码兰诺定受体同源物的基因已经被多个昆虫家族表征。 基因及其相应的多肽具有多种用途，包括但不限于筛选鉴定杀虫活性化合物的筛选。 概述了克服在宿主细胞中表达重组蛋白的毒性作用的方法。
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公开(公告)号：US07655395B2
公开(公告)日：2010-02-02
申请号：US11715725
申请日：2007-03-08
Applicant: Timothy Casper , Daniel Cordova , Steven Gutteridge , James J Rauh , Rejane M Smith , Lihong Wu , Yong Tao
Inventor： Timothy Casper , Daniel Cordova , Steven Gutteridge , James J Rauh , Rejane M Smith , Lihong Wu , Yong Tao
CPC classification number: C07K14/43563 , C07K14/705
Abstract: The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis virescens), homopteran green peach aphid (Myzus persicae), corn plant hopper (Peregrinus maidis), cotton melon aphid (Aphis gossypil) and fruitfly (Drosophila melanogaster). The full-length genes have been isolated, cloned and amplified in bacterial cells. Expression in insect cells shows that the recombinant protein folds into a functional calcium release channel. The genes and their corresponding polypeptides have a number of uses including, but not limited to, the isolation of other pest ryanodine receptors, the development of screens to identify insecticidally active compounds, use of fragments of genes as pesticides, fragments of protein for antibody production, fragments of protein for determination of the structure of insecticide binding sites, and identification of insecticides that disrupt the calcium balance in cells through other messengers that interact with the receptor calcium release mechanism. Methods are outlined for overcoming toxic effects of expressing recombinant proteins in host cells.
Abstract translation: 编码兰诺定受体同源物的基因已经被多种昆虫家族表征，包括鳞翅目叶烟芽夜蛾（Heliothis virescens），同翅目绿桃蚜（Myzus persicae），玉米植物料斗（Peregrinus maidis），棉瓜蚜虫（Aphis gossypil）和果蝇 黑腹果蝇）。 全长基因已经在细菌细胞中被分离，克隆和扩增。 昆虫细胞中的表达显示重组蛋白折叠成功能性钙释放通道。 基因及其相应的多肽具有许多用途，包括但不限于分离其它害虫兰诺定受体，筛选鉴定杀虫活性化合物，使用基因片段作为农药，用于抗体生产的蛋白质片段 ，用于测定杀虫剂结合位点结构的蛋白质片段，以及鉴定通过与受体钙释放机制相互作用的其他信使破坏细胞中钙平衡的杀虫剂。 概述了克服在宿主细胞中表达重组蛋白的毒性作用的方法。
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公开(公告)号：US07034206B2
公开(公告)日：2006-04-25
申请号：US10359513
申请日：2003-02-06
Applicant: Karlene H. Butler , Steven Gutteridge , Leslie T. Harvell
Inventor： Karlene H. Butler , Steven Gutteridge , Leslie T. Harvell
IPC: A01H1/00 , C07H21/04 , C07K14/415 , C12N5/14 , C12N9/00
CPC classification number: C12N9/80
Abstract: This invention relates to an isolated nucleic acid fragment encoding a metalloprotease, more specifically peptide deformylase. The invention also relates to the construction of a recombinant DNA construct encoding all or a portion of peptide deformylase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of peptide deformylase in a transformed host cell.
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Patent Agency Ranking
公开(公告)号：US20110269144A9
公开(公告)日：2011-11-03
申请号：US12635859
申请日：2009-12-11
Applicant: Steven Gutteridge , Timothy Caspar , Daniel Cordova , James J. Rauh , Yong Tao , Lihong Wu , Rejane M. Smith
Inventor： Steven Gutteridge , Timothy Caspar , Daniel Cordova , James J. Rauh , Yong Tao , Lihong Wu , Rejane M. Smith
IPC: C12Q1/68 , C12N15/63 , C12N5/10 , C12P21/00 , C12N1/19 , C07K14/705 , G01N33/68 , C07H21/00 , C12N1/21
CPC classification number: C07K14/43563 , C07K14/705
Abstract: The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis virescens), homopteran green peach aphid (Myzus persicae), corn plant hopper (Peregrinus maidis), cotton melon aphid (Aphis gossypii) and fruitfly (Drosophila melanogaster). The full-length genes have been isolated, cloned and amplified in bacterial cells. Expression in insect cells shows that the recombinant protein folds into a functional calcium release channel. The genes and their corresponding polypeptides have a number of uses including, but not limited to, the isolation of other pest ryanodine receptors, the development of screens to identify insecticidally active compounds, use of fragments of genes as pesticides, fragments of protein for antibody production, fragments of protein for determination of the structure of insecticide binding sites, and identification of insecticides that disrupt the calcium balance in cells through other messengers that interact with the receptor calcium release mechanism. Methods are outlined for overcoming toxic effects of expressing recombinant proteins in host cells.
Abstract translation: 编码兰诺定受体同系物的基因已经被多种昆虫家族表征，包括鳞翅目叶烟芽夜蛾（Heliothis virescens），同翅目绿桃蚜虫（Myzus persicae），玉米植物漏斗（Peregrinus maidis），棉花蚜虫（Aphis gossypii）和果蝇 黑腹果蝇）。 全长基因已经在细菌细胞中被分离，克隆和扩增。 昆虫细胞中的表达显示重组蛋白折叠成功能性钙释放通道。 基因及其相应的多肽具有许多用途，包括但不限于分离其它害虫兰诺定受体，筛选鉴定杀虫活性化合物，使用基因片段作为农药，蛋白质片段用于抗体生产 ，用于测定杀虫剂结合位点结构的蛋白质片段，以及鉴定通过与受体钙释放机制相互作用的其他信使破坏细胞中钙平衡的杀虫剂。 概述了克服在宿主细胞中表达重组蛋白的毒性作用的方法。
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公开(公告)号：US20110086345A1
公开(公告)日：2011-04-14
申请号：US12635859
申请日：2009-12-11
Applicant: Steven Gutteridge , Timothy Caspar , Daniel Cordova , James J. Rauh , Yong Tao , Lihong Wu , Rejane M. Smith
Inventor： Steven Gutteridge , Timothy Caspar , Daniel Cordova , James J. Rauh , Yong Tao , Lihong Wu , Rejane M. Smith
IPC: C12Q1/68 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C07K14/705 , G01N33/68 , C12P21/00
CPC classification number: C07K14/43563 , C07K14/705
Abstract: The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis virescens), homopteran green peach aphid (Myzus persicae), corn plant hopper (Peregrinus maidis), cotton melon aphid (Aphis gossypii) and fruitfly (Drosophila melanogaster). The full-length genes have been isolated, cloned and amplified in bacterial cells. Expression in insect cells shows that the recombinant protein folds into a functional calcium release channel. The genes and their corresponding polypeptides have a number of uses including, but not limited to, the isolation of other pest ryanodine receptors, the development of screens to identify insecticidally active compounds, use of fragments of genes as pesticides, fragments of protein for antibody production, fragments of protein for determination of the structure of insecticide binding sites, and identification of insecticides that disrupt the calcium balance in cells through other messengers that interact with the receptor calcium release mechanism. Methods are outlined for overcoming toxic effects of expressing recombinant proteins in host cells.
Abstract translation: 编码兰诺定受体同系物的基因已经被多种昆虫家族表征，包括鳞翅目叶烟芽夜蛾（Heliothis virescens），同翅目绿桃蚜虫（Myzus persicae），玉米植物漏斗（Peregrinus maidis），棉花蚜虫（Aphis gossypii）和果蝇 黑腹果蝇）。 全长基因已经在细菌细胞中被分离，克隆和扩增。 昆虫细胞中的表达显示重组蛋白折叠成功能性钙释放通道。 基因及其相应的多肽具有许多用途，包括但不限于分离其它害虫兰诺定受体，筛选鉴定杀虫活性化合物的筛选，使用基因片段作为农药，用于抗体生产的蛋白质片段 ，用于测定杀虫剂结合位点结构的蛋白质片段，以及鉴定通过与受体钙释放机制相互作用的其他信使破坏细胞中钙平衡的杀虫剂。 概述了克服在宿主细胞中表达重组蛋白的毒性作用的方法。
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公开(公告)号：US07498408B2
公开(公告)日：2009-03-03
申请号：US10528611
申请日：2003-09-23
Applicant: Steven Gutteridge , Timothy Caspar , Daniel Cordova , James J. Rauh , Rejane M. Smith , Lihong Wu , Yong Tao
Inventor： Steven Gutteridge , Timothy Caspar , Daniel Cordova , James J. Rauh , Rejane M. Smith , Lihong Wu , Yong Tao
CPC classification number: C07K14/43563 , C07K14/705
Abstract: The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis virescens), homopteran green peach aphid (Myzus persicae), corn plant hopper (Peregrinus maidis), cotton melon aphid (Aphis gossypii) and fruitfly (Drosophila melanogaster). The full-length genes have been isolated, cloned and amplified in bacterial cells. Expression in insect cells shows that the recombinant protein folds into a functional calcium release channel. The genes and their corresponding polypeptides have a number of uses including, but not limited to, the isolation of other pest ryanodine receptors, the development of screens to identify insecticidally active compounds, use of fragments of genes as pesticides, fragments of protein for antibody production, fragments of protein for determination of the structure of insecticide binding sites, and identification of insecticides that disrupt the calcium balance in cells through other messengers that interact with the receptor calcium release mechanism. Methods are outlined for overcoming toxic effects of expressing recombinant proteins in host cells.
Abstract translation: 编码兰诺定受体同系物的基因已经被多种昆虫家族表征，包括鳞翅目叶烟芽夜蛾（Heliothis virescens），同翅目绿桃蚜虫（Myzus persicae），玉米植物漏斗（Peregrinus maidis），棉花蚜虫（Aphis gossypii）和果蝇 黑腹果蝇）。 全长基因已经在细菌细胞中被分离，克隆和扩增。 昆虫细胞中的表达显示重组蛋白折叠成功能性钙释放通道。 基因及其相应的多肽具有许多用途，包括但不限于分离其它害虫兰诺定受体，筛选鉴定杀虫活性化合物，使用基因片段作为农药，蛋白质片段用于抗体生产 ，用于测定杀虫剂结合位点结构的蛋白质片段，以及鉴定通过与受体钙释放机制相互作用的其他信使破坏细胞中钙平衡的杀虫剂。 概述了克服在宿主细胞中表达重组蛋白的毒性作用的方法。
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公开(公告)号：US07205147B2
公开(公告)日：2007-04-17
申请号：US10668767
申请日：2003-09-23
Applicant: Steven Gutteridge , Timothy Caspar , Daniel Cordova , Yong Tao , Lihong Wu , Rejane M. Smith
Inventor： Steven Gutteridge , Timothy Caspar , Daniel Cordova , Yong Tao , Lihong Wu , Rejane M. Smith
IPC: C12N5/16 , C12N5/21 , C12N15/63 , C07H21/04 , C07K14/705
CPC classification number: C07K14/43563 , C07K14/705
Abstract: The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis virescens), homopteran green peach aphid (Myzus persicae), corn plant hopper (Peregrinus maidis), cotton melon aphid (Aphis gossypii) and fruitfly (Drosophila melanogaster). The full-length genes have been isolated, cloned and amplified in bacterial cells. Expression in insect cells shows that the recombinant protein folds into a functional calcium release channel. The genes and their corresponding polypeptides have a number of uses including, but not limited to, the isolation of other pest ryanodine receptors, the development of screens to identify insecticidally active compounds, use of fragments of genes as pesticides, fragments of protein for antibody production, fragments of protein for determination of the structure of insecticide binding sites, and identification of insecticides that disrupt the calcium balance in cells through other messengers that interact with the receptor calcium release mechanism. Methods are outlined for overcoming toxic effects of expressing recombinant proteins in host cells.
Abstract translation: 编码兰诺定受体同系物的基因已经被多种昆虫家族表征，包括鳞翅目叶烟芽夜蛾（Heliothis virescens），同翅目绿桃蚜虫（Myzus persicae），玉米植物漏斗（Peregrinus maidis），棉花蚜虫（Aphis gossypii）和果蝇 黑腹果蝇）。 全长基因已经在细菌细胞中被分离，克隆和扩增。 昆虫细胞中的表达显示重组蛋白折叠成功能性钙释放通道。 基因及其相应的多肽具有许多用途，包括但不限于分离其它害虫兰诺定受体，筛选鉴定杀虫活性化合物，使用基因片段作为农药，用于抗体生产的蛋白质片段 ，用于测定杀虫剂结合位点结构的蛋白质片段，以及鉴定通过与受体钙释放机制相互作用的其他信使破坏细胞中钙平衡的杀虫剂。 概述了克服在宿主细胞中表达重组蛋白的毒性作用的方法。
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公开(公告)号：US20060288441A1
公开(公告)日：2006-12-21
申请号：US11506552
申请日：2006-08-18
Applicant: Steven Gutteridge , Leslie Harvell
Inventor： Steven Gutteridge , Leslie Harvell
CPC classification number: C12N9/93 , C12N15/8274
Abstract: This invention relates to isolated nucleic acid fragments encoding pantothenate synthetases. The invention also relates to the construction of chimeric genes encoding all or a portion of the pantothenate synthetases, in sense or antisense orientation, wherein expression of the chimeric genes results in production of altered levels of the pantothenate synthetases in transformed host cells.
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