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公开(公告)号:US08357798B2
公开(公告)日:2013-01-22
申请号:US12793801
申请日:2010-06-04
申请人: Kevin M. Belyk , Henry G. Morrison , Philip Jones , Vincenzo Summa , V. Brett Cooper , Amar J. Mahajan , Daniel J. Kumke , Hsien-Hsin Tung , Lawrence Wai , Vanessa Pruzinsky , Philip Pye , Remy Angelaud , Danny Mancheno
发明人: Kevin M. Belyk , Henry G. Morrison , Philip Jones , Vincenzo Summa , V. Brett Cooper , Amar J. Mahajan , Daniel J. Kumke , Hsien-Hsin Tung , Lawrence Wai , Vanessa Pruzinsky , Philip Pye , Remy Angelaud , Danny Mancheno
IPC分类号: C07D239/54
CPC分类号: C07D239/557 , C07D313/12 , C07D413/12
摘要: Potassium salts of Compound A and methods for their preparation are disclosed, wherein Compound A is of formula: Compound A is an HIV integrase inhibitor useful for treating or prophylaxis of HIV infection, for delaying the onset of AIDS, and for treating or prophylaxis of AIDS.
摘要翻译: 公开了化合物A的钾盐及其制备方法,其中化合物A具有下式:化合物A是可用于治疗或预防HIV感染,延迟AIDS发作和用于治疗或预防艾滋病的HIV整合酶抑制剂 。
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公开(公告)号:US06521625B2
公开(公告)日:2003-02-18
申请号:US09870560
申请日:2001-05-31
IPC分类号: A61K31497
CPC分类号: C07D401/14
摘要: Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions and are selected from the group consisting of 3-Fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide polymorphic crystalline Anhydrous Form B, 3-Fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide polymorphic crystalline form Type A Monohydrate, and 3-Fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide polymorphic crystalline form Type B monohydrate, or a pharmaceutically acceptable salt thereof.
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