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公开(公告)号：US20090281168A1
公开(公告)日：2009-11-12
申请号：US11978786
申请日：2007-10-29
IPC分类号： A61K31/7088 , C07H21/00 , C12N15/63 , C12N1/21 , C12P21/02
CPC分类号： C12N15/62 , C07K2319/40
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种结核分枝杆菌抗原的融合蛋白。 特别涉及包含两种单独的结核分枝杆菌抗原的双融合蛋白，含有三种结核分枝杆菌抗原的三融合蛋白，含有四种结核分枝杆菌抗原的四融合蛋白和含有四种结核分枝杆菌抗原的五融合蛋白， 五种结核分枝杆菌抗原及其用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US20090022755A1
公开(公告)日：2009-01-22
申请号：US11909992
申请日：2006-03-24
申请人： Brenda Barth , Ajay Bhatia , Mark Alderson , Jean-Francois L. Maisonneuve , Yves Lobet , Florence Bernadette Nozay , Martine Marchand , Pascal Mettens , Yasir A. Skeiky , Peter Probst
发明人： Brenda Barth , Ajay Bhatia , Mark Alderson , Jean-Francois L. Maisonneuve , Yves Lobet , Florence Bernadette Nozay , Martine Marchand , Pascal Mettens , Yasir A. Skeiky , Peter Probst
CPC分类号： A61K39/118 , A61K2039/55572 , A61K2039/55577 , C07K14/295
摘要： The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
摘要翻译： 本发明涉及包含衣原体属的蛋白质或多核苷酸的组合物，特别是编码它们的蛋白质或多核苷酸的组合，以及用于治疗，预防和诊断衣原体感染的蛋白质或多核苷酸的方法。
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公开(公告)号：US06977069B2
公开(公告)日：2005-12-20
申请号：US10359460
申请日：2003-02-05
CPC分类号： A61K39/04 , A61K38/00 , A61K39/00 , A61K2039/51 , A61K2039/55505 , C07K14/35 , C07K2319/00 , C07K2319/40 , C12N15/62
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种结核分枝杆菌抗原的融合蛋白。 特别涉及包含两种单独的结核分枝杆菌抗原的双融合蛋白，含有三种结核分枝杆菌抗原的三融合蛋白，含有四种结核分枝杆菌抗原的四融合蛋白和含有四种结核分枝杆菌抗原的五融合蛋白， 五种结核分枝杆菌抗原及其用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US06607731B1
公开(公告)日：2003-08-19
申请号：US09565501
申请日：2000-05-05
申请人： Steven G. Reed , Antonio Campos-Neto , John R. Webb , Davin C. Dillon , Yasir A. Skeiky , Ajay Bhatia , Rhea Coler , Peter Probst
发明人： Steven G. Reed , Antonio Campos-Neto , John R. Webb , Davin C. Dillon , Yasir A. Skeiky , Ajay Bhatia , Rhea Coler , Peter Probst
IPC分类号： A61K39008
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00 , Y02A50/41
摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.
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公开(公告)号：US08143386B2
公开(公告)日：2012-03-27
申请号：US11978786
申请日：2007-10-29
CPC分类号： C12N15/62 , C07K2319/40
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种结核分枝杆菌抗原的融合蛋白。 特别涉及包含两种单独的结核分枝杆菌抗原的双融合蛋白，含有三种结核分枝杆菌抗原的三融合蛋白，含有四种结核分枝杆菌抗原的四融合蛋白和含有四种结核分枝杆菌抗原的五融合蛋白， 五种结核分枝杆菌抗原及其用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US20110300206A1
公开(公告)日：2011-12-08
申请号：US12974428
申请日：2010-12-21
申请人： Mark ALDERSON , Ajay BHATIA , Yves LOBET , Brenda MAISONNEUVE , Jean-Francois L. MAISONNEUVE , Martine MARCHAND , Pascal METTENS , Florence Bernadette NOZAY , Peter PROBST , Yasir A. SKEIKY , Samira H. SKEIKY
发明人： Mark ALDERSON , Ajay BHATIA , Yves LOBET , Brenda MAISONNEUVE , Jean-Francois L. MAISONNEUVE , Martine MARCHAND , Pascal METTENS , Florence Bernadette NOZAY , Peter PROBST , Yasir A. SKEIKY , Samira H. SKEIKY
IPC分类号： A61K39/118 , G01N33/53 , C12Q1/02 , A61K9/127 , A61P31/04
CPC分类号： A61K39/118 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , G01N33/56927
摘要： The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
摘要翻译： 本发明涉及包含衣原体属的蛋白质或多核苷酸的组合物，特别是编码它们的蛋白质或多核苷酸的组合，以及用于治疗，预防和诊断衣原体感染的蛋白质或多核苷酸的方法。
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公开(公告)号：US06627198B2
公开(公告)日：2003-09-30
申请号：US09287849
申请日：1999-04-07
IPC分类号： A61K3902
CPC分类号： A61K39/04 , A61K38/00 , A61K39/00 , A61K2039/51 , A61K2039/55505 , C07K14/35 , C07K2319/00 , C07K2319/40 , C12N15/62
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种结核分枝杆菌抗原的融合蛋白。 特别涉及包含两种单独的结核分枝杆菌抗原的双融合蛋白，含有三种结核分枝杆菌抗原的三融合蛋白，含有四种结核分枝杆菌抗原的四融合蛋白和含有四种结核分枝杆菌抗原的五融合蛋白， 五种结核分枝杆菌抗原及其用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US07335369B2
公开(公告)日：2008-02-26
申请号：US11511587
申请日：2006-08-28
CPC分类号： A61K39/04 , A61K38/00 , A61K39/00 , A61K2039/51 , A61K2039/55505 , C07K14/35 , C07K2319/00 , C07K2319/40 , C12N15/62
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种结核分枝杆菌抗原的融合蛋白。 特别涉及包含两种单独的结核分枝杆菌抗原的双融合蛋白，含有三种结核分枝杆菌抗原的三融合蛋白，含有四种结核分枝杆菌抗原的四融合蛋白和含有四种结核分枝杆菌抗原的五融合蛋白， 五种结核分枝杆菌抗原及其用于诊断，治疗和预防结核病感染的方法。
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