公开(公告)号：US06407228B1

公开(公告)日：2002-06-18

申请号：US08527217

申请日：1995-09-12

Applicant: Yoichi Taguchi ,  Akihiro Oishi ,  Isao Shibuya ,  Tohru Tsuchiya

Inventor： Yoichi Taguchi ,  Akihiro Oishi ,  Isao Shibuya ,  Tohru Tsuchiya

IPC: C07D20508

CPC classification number: C07D201/02 ,  C07D205/08

Abstract: A simple and efficient method is proposed for the preparation of a &bgr;-lactam compound such as 1-phenyl-4-ethoxy-2-azetidinone which can be produced by mixing an isocyanate compound such as phenyl isocyanate and a vinyl ether compound such as ethyl vinyl ether and heating the mixture at a moderate temperature under a superatmospheric pressure of up to 12000 atmospheres.

Abstract translation: 提出了一种制备β-内酰胺化合物如1-苯基-4-乙氧基-2-氮杂环丁酮的简单且有效的方法，其可以通过将异氰酸酯化合物如异氰酸苯酯和乙烯基醚化合物如乙基 乙烯基醚，并在中等温度下在高达12000个大气压的超大气压下加热该混合物。

公开(公告)号：US06180751B2

公开(公告)日：2001-01-30

申请号：US09499518

申请日：2000-02-10

Applicant: Yoichi Taguchi ,  Akihiro Oishi ,  Yoshikazu Ikeda ,  Ken-ichi Fujita ,  Takashi Masuda

Inventor： Yoichi Taguchi ,  Akihiro Oishi ,  Yoshikazu Ikeda ,  Ken-ichi Fujita ,  Takashi Masuda

IPC: C08G6348

CPC classification number: C08G63/16 ,  C08G63/20

Abstract: An aliphatic copolyester having a plurality of first: ester units of the formula: —CO—[R1]t—CO—O—R2—O— wherein R1 represents a divalent aliphatic group, R2 represents a divalent aliphatic and t is an integer of 0 or 1, and a plurality of second ester units of the formula: wherein R1 and t are as defined above and R3 represents an aliphatic group. The molar ratio of the first ester unit to the second ester unit is 90:10 to 99.9:0.1. The copolyester is produced by reacting an aliphatic diester with an aliphatic glycol and with a monoacylated glycerin under ester exchanging conditions.

Abstract translation: 具有多个下式的第一酯单元的脂族共聚酯：其中R1表示二价脂族基团，R2表示二价脂族基，t表示0或1的整数，以及多个下式的第二酯单元：其中 R 1和t如上所定义，R 3表示脂族基团。 第一酯单元与第二酯单元的摩尔比为90:10至99.9:0.1。 共聚多酯是通过脂肪族二酯与酯交换条件下的单酰化甘油反应制备的。

公开(公告)号：US06177539B1

公开(公告)日：2001-01-23

申请号：US09531431

申请日：2000-03-20

Applicant: Akihiro Oishi ,  Yoichi Taguchi ,  Ken-ichi Fujita ,  Yoshikazu Ikeda ,  Takashi Masuda ,  Yutaka Ishigami ,  Kazuo Nakayama ,  Shinichi Kinugasa ,  Hisae Nakahara

Inventor： Akihiro Oishi ,  Yoichi Taguchi ,  Ken-ichi Fujita ,  Yoshikazu Ikeda ,  Takashi Masuda ,  Yutaka Ishigami ,  Kazuo Nakayama ,  Shinichi Kinugasa ,  Hisae Nakahara

IPC: C08G1000

CPC classification number: C08G63/823 ,  C08G63/08

Abstract: A process of producing a polyester or copolyester, wherein at least one cyclic lactone of the following formula (I): wherein n is an integer of 1-4 provided that n is not 2 when only one cyclic lactone is used, is polymerized under a pressure of at least 200 MPa in the absence of any catalyst or in the presence of a metal-free polyesterification catalyst.

Abstract translation: 一种生产聚酯或共聚酯的方法，其中至少一种下式（I）的环状内酯：其中n为1-4的整数，条件是当仅使用一个环状内酯时，n不为2，在 在不存在任何催化剂的情况下或在不含金属的聚酯化催化剂存在下，压力至少为200MPa。

公开(公告)号：US06403756B1

公开(公告)日：2002-06-11

申请号：US09981758

申请日：2001-10-19

Applicant: Yoichi Taguchi ,  Akihiro Oishi ,  Yoshikazu Ikeda ,  Ken-ichi Fujita ,  Takashi Masuda

Inventor： Yoichi Taguchi ,  Akihiro Oishi ,  Yoshikazu Ikeda ,  Ken-ichi Fujita ,  Takashi Masuda

IPC: C08G6366

CPC classification number: C08G63/16 ,  C08G63/672

Abstract: Disclosed is a novel, high molecular weight aliphatic polyester having excellent mechanical strengths such as breaking strain and containing a copolymer structure with 3-alkoxy-1,2-propane diol and a method of producing the aliphatic polyester in an industrially advantageous manner. The aliphatic polyester is a biodegradable high molecular weight aliphatic polyester having an ester structure derived from 3-alkoxy-1,2-propane diol.

Abstract translation: 公开了一种具有优异的机械强度例如断裂应变并含有与3-烷氧基-1,2-丙二醇的共聚物结构的新型高分子量脂族聚酯，以及以工业上有利的方式制备脂肪族聚酯的方法。 脂肪族聚酯是具有衍生自3-烷氧基-1,2-丙二醇的酯结构的生物降解性高分子量脂肪族聚酯。

公开(公告)号：US5677444A

公开(公告)日：1997-10-14

申请号：US530402

申请日：1995-09-15

Applicant: Tohru Tsuchiya ,  Isao Shibuya ,  Yoichi Taguchi ,  Akihiro Oishi ,  Kazumasa Honda

Inventor： Tohru Tsuchiya ,  Isao Shibuya ,  Yoichi Taguchi ,  Akihiro Oishi ,  Kazumasa Honda

IPC: C07D223/08 ,  C07C327/42 ,  C07C327/44 ,  C07D223/02 ,  C07D223/06 ,  C07D225/02

CPC classification number: C07C327/44 ,  C07C327/42 ,  C07D223/06 ,  C07D225/02

Abstract: A novel and simple method is proposed for the synthetic preparation of an N,N-disubstituted .beta.-ketothioamide compound represented by the general formula R.sup.1 R.sup.2 N--CS--CH.sub.2 --CO--R.sup.3, in which R.sup.1 and R.sup.2 are each a monovalent hydrocarbon group or each a divalent hydrocarbon group jointly forming a cyclic structure together with the nitrogen atom and R.sup.3 is a hydrogen atom, a monovalent hydrocarbon group or a divalent hydrocarbon group forming a cyclic structure jointly with R.sup.1, R.sup.1 being a divalent hydrocarbon group and R.sup.2 being a monovalent hydrocarbon group. The method comprises:(a) mixing an N,N-disubstituted amide compound represented by the general formula R.sup.1 R.sup.2 N--CO--R.sup.3, and a bis(trialkylsilyl)thioketene compound represented by the general formula (R.sub.3 Si).sub.2 C.dbd.C.dbd.S, in which each R is an alkyl group, to effect an addition reaction therebetween forming an intermediate compound; and (b) dissolving the intermediate compound obtained in step (a) in an alcohol.

Abstract translation: 提出了一种简单的方法，用于合成制备由通式R 1 R 2 N-CS-CH 2 -CO-R 3表示的N，N-二取代的β-酮硫代酰胺化合物，其中R 1和R 2各自是一价烃基， 二价烃基与氮原子一起形成环状结构，R 3为氢原子，一价烃基或二价烃基，与R 1一起形成环状结构，R 1为二价烃基，R 2为一价烃基 。 该方法包括：（a）将由通式R 1 R 2 N -CO-R 3表示的N，N-二取代酰胺化合物和由通式（R3Si）2C = C = S表示的双（三烷基甲硅烷基）硫代烯酮化合物混合，其中 每个R是烷基，以形成中间体化合物之间的加成反应; 和（b）将步骤（a）中获得的中间体化合物溶解在醇中。

公开(公告)号：US5585487A

公开(公告)日：1996-12-17

申请号：US613100

申请日：1996-03-08

Applicant: Akihiro Oishi ,  Yoichi Taguchi ,  Isao Shibuya ,  Tohru Tsuchiya

Inventor： Akihiro Oishi ,  Yoichi Taguchi ,  Isao Shibuya ,  Tohru Tsuchiya

IPC: B01J3/00 ,  C07D491/048 ,  C07D493/04 ,  C07D205/095

CPC classification number: C07D493/04

Abstract: Disclosed is a method for the preparation of a .beta.-thiolactam compound, i.e. a 7-substituted-2-oxa-7-azabicyclo [3.2.0]-heptan-6-thione, represented by the general formula ##STR1## in which R is an alkyl or aryl group, having usefulness as an intermediate for the synthesis of various biologically active compounds. The compound can be prepared by the reaction of an isothiocyanate compound R--NCS, R being the same as above, and 2,3-dihydrofuran, preferably, under pressurization up to 2000 atmospheres or higher at an elevated temperature.

Abstract translation: 公开了一种制备β-硫代内酰胺化合物的方法，即由通式“IMAGE”表示的7-取代-2-氧杂-7-氮杂双环[3.2.0]庚基-6-硫酮，其中R 是具有作为合成各种生物活性化合物的中间体的有用性的烷基或芳基。 该化合物可以通过异硫氰酸酯化合物R-NCS，与上述相同的R和2,3-二氢呋喃的反应制备，优选在高达2000℃或更高的加压下进行。

公开(公告)号：US5138053A

公开(公告)日：1992-08-11

申请号：US793014

申请日：1991-11-15

Applicant: Masahiko Yasumoto ,  Touru Tsuchiya ,  Yoichi Taguchi ,  Isao Shibuya ,  Katsumi Yonemoto

Inventor： Masahiko Yasumoto ,  Touru Tsuchiya ,  Yoichi Taguchi ,  Isao Shibuya ,  Katsumi Yonemoto

IPC: C07D285/34

CPC classification number: C07D285/34

Abstract: There is disclosed a method for producing 2,6-bis(disubstituted amino)-1,3,5-thiadiazine-4-one compounds represented by formula (I). The method comprises reacting an N,N-disubstituted cyanamide represented by formula (II) with carbonyl sulfide represented by formula (III) under a high pressure. Formula (I) ##STR1## wherein R.sub.1 and R.sub.2 each represent an alkyl group or R.sub.1 and R.sub.2 may bond together to form a ring, Formula (II) ##STR2## wherein R.sub.1 and R.sub.2 each have the same meanings as in formula (I), Formula (III)S.dbd.C.dbd.O.

公开(公告)号：US5700931A

公开(公告)日：1997-12-23

申请号：US654521

申请日：1996-05-29

Applicant: Yoichi Taguchi ,  Akihiro Oishi ,  Isao Shibuya ,  Tohru Tsuchiya

Inventor： Yoichi Taguchi ,  Akihiro Oishi ,  Isao Shibuya ,  Tohru Tsuchiya

IPC: A01N43/90 ,  C07D491/04 ,  C07D491/048 ,  A61K31/395

CPC classification number: C07D491/04 ,  A01N43/90

Abstract: Disclosed is a novel .beta.-lactam compound, a 7-substituted-2-oxa-7-azabicyclo�3.2.0!heptan-6-one represented by the general formula ##STR1## in which R is an alkyl, cycloalkyl, aryl, halogen-substituted aryl or alkaryl group, having usefulness as an intermediate for the synthesis of various biologically active compounds. The compound can be prepared by the reaction of an isocyanate compound RNCO, R being the same as above, and 2,3-dihydrofuran, preferably, under pressurization up to 2000 atmospheres or higher.

Abstract translation: 公开了一种新的β-内酰胺化合物，由通式“IMAGE”表示的7-取代-2-氧杂-7-氮杂双环[3.2.0]庚-6-酮，其中R是烷基，环烷基，芳基， 卤素取代的芳基或烷芳基，其作为用于合成各种生物活性化合物的中间体具有有用性。 化合物可以通过异氰酸酯化合物RNCO，与上述相同的R和2,3-二氢呋喃的反应来制备，优选在加压至2000个大气压或更高的条件下进行。

公开(公告)号：US5550230A

公开(公告)日：1996-08-27

申请号：US396778

申请日：1995-03-01

Applicant: Yoichi Taguchi ,  Akihiro Oishi ,  Isao Shibuya ,  Tohru Tsuchiya

Inventor： Yoichi Taguchi ,  Akihiro Oishi ,  Isao Shibuya ,  Tohru Tsuchiya

IPC: A01N43/90 ,  C07D491/04 ,  C07D491/048 ,  A61K31/395

CPC classification number: C07D491/04 ,  A01N43/90

Abstract: Disclosed is a novel .beta.-lactam compound, a 7-substituted-2-oxa-7-azabicyclo[3.2.0]heptan-6-one represented by the general formula ##STR1## in which R is an alkyl, cycloalkyl, aryl, halogen-substituted aryl or alkaryl group, having usefulness as an intermediate for the synthesis of various biologically active compounds. The compound can be prepared by the reaction of an isocyanate compound RNCO, R being the same as above, and 2,3-dihydrofuran, preferably, under pressurization up to 2000 atmospheres or higher.

Abstract translation: 公开了一种新的β-内酰胺化合物，由通式“IMAGE”表示的7-取代-2-氧杂-7-氮杂双环[3.2.0]庚-6-酮，其中R是烷基，环烷基，芳基， 卤素取代的芳基或烷芳基，其作为用于合成各种生物活性化合物的中间体具有有用性。 化合物可以通过异氰酸酯化合物RNCO，与上述相同的R和2,3-二氢呋喃的反应来制备，优选在加压至2000个大气压或更高的条件下进行。