公开(公告)号：US08232321B2

公开(公告)日：2012-07-31

申请号：US12670181

申请日：2008-07-25

申请人： Takashi Ohmori ,  Akira Ishikubo ,  Yuki Sugiyama ,  Yuko Matsui ,  Tomoyuki Kawasoe ,  Yoji Tezuka ,  Hiroyasu Mizuno ,  Kei-ichi Maruyama

发明人： Takashi Ohmori ,  Akira Ishikubo ,  Yuki Sugiyama ,  Yuko Matsui ,  Tomoyuki Kawasoe ,  Yoji Tezuka ,  Hiroyasu Mizuno ,  Kei-ichi Maruyama

IPC分类号： C08G65/28 ,  A61K31/77 ,  A61K8/86 ,  A61Q1/02 ,  A61Q19/00 ,  A61P17/16

CPC分类号： A61Q1/02 ,  A61K8/86 ,  A61Q19/00 ,  C08G65/2609 ,  C08G65/2615 ,  C08G65/337 ,  C08L71/02

摘要： The present invention is to provide a new compound having a rough skin improving effect, excellent in safety, excellent in texture in use, especially free of sticky feeling, excellent in refreshing feeling, and capable to improve the base agent stability as a component. An alkylene oxide derivative is characterized by being represented by the below-described general formula (I): (formula I) Z—{O-[(AO)a-(EO)b]-R}2  (I) (In the formula, Z is the residue obtained by removing hydroxyl groups from the dimer diol, EO is an oxyethylene group, AO is an oxyalkylene group having 3 to 4 carbon atoms, and the addition form is block-type. The symbols a and b are the average addition mole numbers of the above-described oxyalkylene group and the oxyethylene group, respectively, and they are 1≦2 a≦150 and 1≦2 b≦150. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 10 to 99 mass %. Rs may be either identical to or different from each other, and they are hydrocarbon groups having 1 to 4 carbon atoms.)

摘要翻译： 本发明提供一种具有粗糙皮肤改善效果，安全性优异，使用质地优异，特别是无粘性，清爽感好，能提高作为成分的基剂稳定性的新化合物。 氧化烯衍生物的特征在于由下述通式（I）表示：（式I）Z- {O - [（AO）a-（EO）b] -R} 2（I） 式中，Z为从二聚二醇中除去羟基得到的残基，EO为氧化乙烯基，AO为碳原子数3〜4的氧化烯基，添加形式为嵌段型，符号a和b为 分别为上述氧化烯基和氧化乙烯基的平均加成摩尔数，它们分别为1和n 1; 2 a＆nlE; 150和1＆nlE; 2 b＆nlE; 150。氧化乙烯基相对于氧化烯基的总和的百分比 具有3〜4个碳原子，氧化乙烯基为10〜99质量％，Rs可以相同也可以不同，为碳原子数1〜4的烃基）

公开(公告)号：US09561172B2

公开(公告)日：2017-02-07

申请号：US14131769

申请日：2012-07-06

申请人： Yoji Tezuka ,  Muneaki Iizuka

发明人： Yoji Tezuka ,  Muneaki Iizuka

IPC分类号： A61K31/74 ,  A61K8/72 ,  A61Q5/00 ,  A61K8/92 ,  A61K8/37 ,  A61K8/39 ,  A61Q19/00 ,  A61K8/86 ,  A61K8/90 ,  A61K8/97 ,  A61K8/31

CPC分类号： A61K8/92 ,  A61K8/31 ,  A61K8/37 ,  A61K8/39 ,  A61K8/86 ,  A61K8/90 ,  A61K8/97 ,  A61K2800/262 ,  A61Q5/00 ,  A61Q19/00

摘要： Provided is a cosmetic composition which has a structure-recovering property, is transparent, is satisfactory in smoothness when applied to the skin or hair, and has a good feeling in use, which comprises components (A) to (D) as described.

摘要翻译： 本发明提供一种化妆品组合物，其具有结构恢复性，透明性，在施用于皮肤或毛发时的平滑性令人满意，并且具有良好的使用感，其含有所述的成分（A）〜（D）。

公开(公告)号：US20140142203A1

公开(公告)日：2014-05-22

申请号：US14131692

申请日：2012-07-06

申请人： Yoji Tezuka ,  Muneaki Iizuka

发明人： Yoji Tezuka ,  Muneaki Iizuka

IPC分类号： A61K8/34 ,  A61K8/37 ,  A61K8/92

CPC分类号： A61K8/34 ,  A61K8/345 ,  A61K8/37 ,  A61K8/375 ,  A61K8/39 ,  A61K8/4973 ,  A61K8/86 ,  A61K8/92 ,  A61K8/922 ,  A61K2800/262 ,  A61K2800/48 ,  A61Q1/14 ,  A61Q5/00 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/10

摘要： Provided is a cosmetic composition which has a structure-recovering property, is transparent, is excellent in thermal stability, is satisfactory in smoothness when applied to the skin or hair, and has a good feeling in use, and which comprises components (A) to (D) as described.

摘要翻译： 本发明提供具有结构恢复性，透明性，热稳定性优异的化妆品组合物，适用于皮肤或毛发时的平滑性良好，使用感好的成分，其含有成分（A）〜 （D）。

公开(公告)号：US20100190864A1

公开(公告)日：2010-07-29

申请号：US12670181

申请日：2008-07-25

申请人： Takashi Ohmori ,  Akira Ishikubo ,  Yuki Sugiyama ,  Yuko Matsui ,  Tomoyuki Kawasoe ,  Yoji Tezuka ,  Hiroyasu Mizuno ,  Kei-ichi Maruyama

发明人： Takashi Ohmori ,  Akira Ishikubo ,  Yuki Sugiyama ,  Yuko Matsui ,  Tomoyuki Kawasoe ,  Yoji Tezuka ,  Hiroyasu Mizuno ,  Kei-ichi Maruyama

IPC分类号： A61K8/86 ,  C07C43/15 ,  A61Q5/12 ,  A61Q1/00 ,  A61Q1/14 ,  A61Q19/10 ,  A61Q5/02

CPC分类号： A61Q1/02 ,  A61K8/86 ,  A61Q19/00 ,  C08G65/2609 ,  C08G65/2615 ,  C08G65/337 ,  C08L71/02

摘要： The present invention is to provide a new compound having a rough skin improving effect, excellent in safety, excellent in texture in use, especially free of sticky feeling, excellent in refreshing feeling, and capable to improve the base agent stability as a component. An alkylene oxide derivative is characterized by being represented by the below-described general formula (I): (formula I) Z-{O-[(AO)a-(EO)b]-R}2  (I) (In the formula, Z is the residue obtained by removing hydroxyl groups from the dimer diol, EO is an oxyethylene group, AO is an oxyalkylene group having 3 to 4 carbon atoms, and the addition form is block-type. The symbols a and b are the average addition mole numbers of the above-described oxyalkylene group and the oxyethylene group, respectively, and they are 1≦2 a≦150 and 1≦2 b≦150. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 10 to 99 mass %. Rs may be either identical to or different from each other, and they are hydrocarbon groups having 1 to 4 carbon atoms.)

摘要翻译： 本发明提供一种具有粗糙皮肤改善效果，安全性优异，使用质地优异，特别是无粘性，清爽感好，能提高作为成分的基剂稳定性的新化合物。 氧化烯衍生物的特征在于由下述通式（I）表示：（式I）Z- {O - [（AO）a-（EO）b] -R} 2（I） 式中，Z为从二聚二醇中除去羟基得到的残基，EO为氧化乙烯基，AO为碳原子数3〜4的氧化烯基，添加形式为嵌段型，符号a和b为 分别为上述氧化烯基和氧化乙烯基的平均加成摩尔数，它们分别为1和n 1; 2 a＆nlE; 150和1＆nlE; 2 b＆nlE; 150。氧化乙烯基相对于氧化烯基的总和的百分比 具有3〜4个碳原子，氧化乙烯基为10〜99质量％，Rs可以相同也可以不同，为碳原子数1〜4的烃基）

公开(公告)号：US20070280897A1

公开(公告)日：2007-12-06

申请号：US11664512

申请日：2005-10-06

申请人： Kei-ichi Maruyama ,  Yoji Tezuka

发明人： Kei-ichi Maruyama ,  Yoji Tezuka

IPC分类号： A61K8/39 ,  A61K8/30

CPC分类号： C07C43/11 ,  A61K8/86 ,  A61K8/90 ,  A61Q19/00 ,  A61Q19/007

摘要： A basic agent for use in cosmetics comprising an alkylene oxide derivative represented by the following formula (I) is provided: Z-{O(AO)l(EO)m-(BO)nH}a   (I) (where Z represents a residue of a compound having 3 to 9 hydroxyl groups with the hydroxyl groups removed, a is from 3 to 9, AO represents an oxyalkylene group of 3 to 4 carbon atoms, EO represents oxyethylene group, l and m represent average additional mol numbers of the oxyalkylene groups of 3 to 4 carbon atoms and the oxyethylene groups, respectively, and 1≦l=50, 1≦m≦50, the weight ratio (AO/EO) of AO to EO is from 1/5 to 5/1, AO and EO may be added in a random form or may be added in a lock form. BO represents oxyalkylene group with a number of carbon atoms of 4, and n is an average additional mol number and 0.5≦n≦5).

摘要翻译： 提供了包含下式（I）表示的氧化烯衍生物的化妆品中使用的碱性试剂：<？在线式说明=“在线式”末端=“铅”→Z- {O（ （I）（I） line-formula description =“In-line Formulas”end =“tail”？>（其中Z表示除去羟基的具有3〜9个羟基的化合物的残基，a为3〜9，AO为氧化烯 3〜4个碳原子的基团，EO表示氧化乙烯基，l和m分别表示3〜4个碳原子的氧化烯基和氧化乙烯基的平均附加摩尔数，1≤i= 50,1 AO = EO，EO与EO的重量比（AO / EO）为1/5至5/1，AO和EO可以以随机形式加入，也可以以锁形式加入，BO表示氧化烯基， 多个碳原子数为4，n为平均附加摩尔数，0.5 <= n <5）。