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    Alkylene oxide derivative and skin external preparation containing the same
    2.
    发明授权
    Alkylene oxide derivative and skin external preparation containing the same 有权
    环氧丙烷衍生物和皮肤外用制剂含有

    公开(公告)号：US08232321B2

    公开(公告)日：2012-07-31

    申请号：US12670181

    申请日：2008-07-25

    申请人： Takashi Ohmori ,  Akira Ishikubo ,  Yuki Sugiyama ,  Yuko Matsui ,  Tomoyuki Kawasoe ,  Yoji Tezuka ,  Hiroyasu Mizuno ,  Kei-ichi Maruyama

    发明人： Takashi Ohmori ,  Akira Ishikubo ,  Yuki Sugiyama ,  Yuko Matsui ,  Tomoyuki Kawasoe ,  Yoji Tezuka ,  Hiroyasu Mizuno ,  Kei-ichi Maruyama

    IPC分类号： C08G65/28 ,  A61K31/77 ,  A61K8/86 ,  A61Q1/02 ,  A61Q19/00 ,  A61P17/16

    CPC分类号： A61Q1/02 ,  A61K8/86 ,  A61Q19/00 ,  C08G65/2609 ,  C08G65/2615 ,  C08G65/337 ,  C08L71/02

    摘要： The present invention is to provide a new compound having a rough skin improving effect, excellent in safety, excellent in texture in use, especially free of sticky feeling, excellent in refreshing feeling, and capable to improve the base agent stability as a component. An alkylene oxide derivative is characterized by being represented by the below-described general formula (I): (formula I) Z—{O-[(AO)a-(EO)b]-R}2  (I) (In the formula, Z is the residue obtained by removing hydroxyl groups from the dimer diol, EO is an oxyethylene group, AO is an oxyalkylene group having 3 to 4 carbon atoms, and the addition form is block-type. The symbols a and b are the average addition mole numbers of the above-described oxyalkylene group and the oxyethylene group, respectively, and they are 1≦2 a≦150 and 1≦2 b≦150. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 10 to 99 mass %. Rs may be either identical to or different from each other, and they are hydrocarbon groups having 1 to 4 carbon atoms.)

    摘要翻译： 本发明提供一种具有粗糙皮肤改善效果，安全性优异，使用质地优异，特别是无粘性，清爽感好，能提高作为成分的基剂稳定性的新化合物。 氧化烯衍生物的特征在于由下述通式（I）表示：（式I）Z- {O - [（AO）a-（EO）b] -R} 2（I） 式中，Z为从二聚二醇中除去羟基得到的残基，EO为氧化乙烯基，AO为碳原子数3〜4的氧化烯基，添加形式为嵌段型，符号a和b为 分别为上述氧化烯基和氧化乙烯基的平均加成摩尔数，它们分别为1和n 1; 2 a＆nlE; 150和1＆nlE; 2 b＆nlE; 150。氧化乙烯基相对于氧化烯基的总和的百分比 具有3〜4个碳原子，氧化乙烯基为10〜99质量％，Rs可以相同也可以不同，为碳原子数1〜4的烃基）

    Alkylene Oxide Derivative And Skin External Preparation Containing The Same
    3.
    发明申请
    Alkylene Oxide Derivative And Skin External Preparation Containing The Same 有权
    含氧化烯衍生物和皮肤外用制剂

    公开(公告)号：US20100190864A1

    公开(公告)日：2010-07-29

    申请号：US12670181

    申请日：2008-07-25

    申请人： Takashi Ohmori ,  Akira Ishikubo ,  Yuki Sugiyama ,  Yuko Matsui ,  Tomoyuki Kawasoe ,  Yoji Tezuka ,  Hiroyasu Mizuno ,  Kei-ichi Maruyama

    发明人： Takashi Ohmori ,  Akira Ishikubo ,  Yuki Sugiyama ,  Yuko Matsui ,  Tomoyuki Kawasoe ,  Yoji Tezuka ,  Hiroyasu Mizuno ,  Kei-ichi Maruyama

    IPC分类号： A61K8/86 ,  C07C43/15 ,  A61Q5/12 ,  A61Q1/00 ,  A61Q1/14 ,  A61Q19/10 ,  A61Q5/02

    CPC分类号： A61Q1/02 ,  A61K8/86 ,  A61Q19/00 ,  C08G65/2609 ,  C08G65/2615 ,  C08G65/337 ,  C08L71/02

    摘要： The present invention is to provide a new compound having a rough skin improving effect, excellent in safety, excellent in texture in use, especially free of sticky feeling, excellent in refreshing feeling, and capable to improve the base agent stability as a component. An alkylene oxide derivative is characterized by being represented by the below-described general formula (I): (formula I) Z-{O-[(AO)a-(EO)b]-R}2  (I) (In the formula, Z is the residue obtained by removing hydroxyl groups from the dimer diol, EO is an oxyethylene group, AO is an oxyalkylene group having 3 to 4 carbon atoms, and the addition form is block-type. The symbols a and b are the average addition mole numbers of the above-described oxyalkylene group and the oxyethylene group, respectively, and they are 1≦2 a≦150 and 1≦2 b≦150. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 10 to 99 mass %. Rs may be either identical to or different from each other, and they are hydrocarbon groups having 1 to 4 carbon atoms.)

    摘要翻译： 本发明提供一种具有粗糙皮肤改善效果，安全性优异，使用质地优异，特别是无粘性，清爽感好，能提高作为成分的基剂稳定性的新化合物。 氧化烯衍生物的特征在于由下述通式（I）表示：（式I）Z- {O - [（AO）a-（EO）b] -R} 2（I） 式中，Z为从二聚二醇中除去羟基得到的残基，EO为氧化乙烯基，AO为碳原子数3〜4的氧化烯基，添加形式为嵌段型，符号a和b为 分别为上述氧化烯基和氧化乙烯基的平均加成摩尔数，它们分别为1和n 1; 2 a＆nlE; 150和1＆nlE; 2 b＆nlE; 150。氧化乙烯基相对于氧化烯基的总和的百分比 具有3〜4个碳原子，氧化乙烯基为10〜99质量％，Rs可以相同也可以不同，为碳原子数1〜4的烃基）

    Cosmetic bases and cosmetics containing the same
    4.
    发明授权
    Cosmetic bases and cosmetics containing the same 有权
    化妆品基地和含有相同的化妆品

    公开(公告)号：US09193654B2

    公开(公告)日：2015-11-24

    申请号：US11664512

    申请日：2005-10-06

    申请人： Kei-ichi Maruyama ,  Yoji Tezuka

    发明人： Kei-ichi Maruyama ,  Yoji Tezuka

    IPC分类号： A61K8/00 ,  A61K8/30 ,  A61K8/34 ,  A61K8/39 ,  C07C43/11 ,  A61K8/86 ,  A61K8/90 ,  A61Q19/00

    CPC分类号： C07C43/11 ,  A61K8/86 ,  A61K8/90 ,  A61Q19/00 ,  A61Q19/007

    摘要： Cosmetic bases consisting of alkylene oxide derivatives represented by the general formula (I): Z—{O(AO)l(EO)m—(BO)nH}a(I) wherein Z is a residue derived from a compound having three to nine hydroxyl groups by the removal of the hydroxyl groups; a is 3 to 9; AO is C3-4 oxyalkylone; EO is oxyethylene; l and m represent the average numbers of added C3-4 oxyalkylene molecules and oxyalkylene molecules respectively and satisfy the relationships: 1≦1≦50 and l≦m≦50 respectively; the AO/EO weight ratio is 1/5 to 5/1 and AO's and EO's may be added at random or in block; BO is oxyalkylene having 4 carbon atoms; and n represents the average number of added BO molecules and satisfies the relationship: 0.5≦n≦5.

    摘要翻译： 由通式（I）表示的氧化烯衍生物：Z- {O（AO）1（EO）m-（BO）nH} a（I）组成的化妆品基质，其中Z是衍生自具有三至 通过去除羟基9个羟基; a是3到9; AO是C3-4氧基; EO是氧化乙烯; l和m分别表示添加的C3-4氧化烯分子和氧化烯分子的平均数，分别满足关系：1＆nlE; 1＆nlE; 50和l＆nlE; m＆nlE; 50; AO / EO重量比为1/5至5/1，AO和EO可以随机或嵌段加入; BO是具有4个碳原子的氧化烯; n表示平均加成BO分子数，满足关系：0.5＆nlE; n＆nlE; 5。

    Cosmetic Bases And Cosmetics Containing The Same
    8.
    发明申请
    Cosmetic Bases And Cosmetics Containing The Same 有权
    化妆品基地和化妆品含有它

    公开(公告)号：US20070280897A1

    公开(公告)日：2007-12-06

    申请号：US11664512

    申请日：2005-10-06

    申请人： Kei-ichi Maruyama ,  Yoji Tezuka

    发明人： Kei-ichi Maruyama ,  Yoji Tezuka

    IPC分类号： A61K8/39 ,  A61K8/30

    CPC分类号： C07C43/11 ,  A61K8/86 ,  A61K8/90 ,  A61Q19/00 ,  A61Q19/007

    摘要： A basic agent for use in cosmetics comprising an alkylene oxide derivative represented by the following formula (I) is provided: Z-{O(AO)l(EO)m-(BO)nH}a   (I) (where Z represents a residue of a compound having 3 to 9 hydroxyl groups with the hydroxyl groups removed, a is from 3 to 9, AO represents an oxyalkylene group of 3 to 4 carbon atoms, EO represents oxyethylene group, l and m represent average additional mol numbers of the oxyalkylene groups of 3 to 4 carbon atoms and the oxyethylene groups, respectively, and 1≦l=50, 1≦m≦50, the weight ratio (AO/EO) of AO to EO is from 1/5 to 5/1, AO and EO may be added in a random form or may be added in a lock form. BO represents oxyalkylene group with a number of carbon atoms of 4, and n is an average additional mol number and 0.5≦n≦5).

    摘要翻译： 提供了包含下式（I）表示的氧化烯衍生物的化妆品中使用的碱性试剂：<？在线式说明=“在线式”末端=“铅”→Z- {O（ （I）（I） line-formula description =“In-line Formulas”end =“tail”？>（其中Z表示除去羟基的具有3〜9个羟基的化合物的残基，a为3〜9，AO为氧化烯 3〜4个碳原子的基团，EO表示氧化乙烯基，l和m分别表示3〜4个碳原子的氧化烯基和氧化乙烯基的平均附加摩尔数，1≤i= 50,1 AO = EO，EO与EO的重量比（AO / EO）为1/5至5/1，AO和EO可以以随机形式加入，也可以以锁形式加入，BO表示氧化烯基， 多个碳原子数为4，n为平均附加摩尔数，0.5 <= n <5）。