公开(公告)号：US20090048557A1

公开(公告)日：2009-02-19

申请号：US12296129

申请日：2007-04-19

申请人： Yehushua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Yoel Sefi ,  Lior Wolloch

发明人： Yehushua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Yoel Sefi ,  Lior Wolloch

IPC分类号： A61B17/00 ,  A61N5/06 ,  A61M35/00

CPC分类号： A61B18/203 ,  A61B2017/320004 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2090/065 ,  A61N5/062 ,  A61N2005/0644 ,  A61N2005/0651 ,  A61N2005/0659

摘要： Method and device for therapeutic or aesthetic treatment of the skin performs a combination of dermabrasion to mechanically modify at least an outer layer of the skin in a first region and phototherapy. The device preferably employs a skin interface element with projections protruding from a substrate which is moved in a vibratory motion by a vibration generating mechanism. This is combined with an illumination system deployed to direct a therapeutically relevant dosage of light towards a surface of the skin against which the skin interface unit is in contact.

摘要翻译： 用于治疗或美学治疗皮肤的方法和装置执行皮肤磨擦的组合以在第一区域中机械修饰皮肤的外层和光疗。 该装置优选采用具有从基板突出的突起的皮肤界面元件，该基板通过振动产生机构以振动运动而移动。 这与照明系统相结合，所述照明系统被部署以将治疗相关剂量的光引向皮肤接触单元所接触的皮肤表面。

公开(公告)号：US20080091226A1

公开(公告)日：2008-04-17

申请号：US11549982

申请日：2006-10-17

申请人： Yehoshua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Gilad Lavi ,  Meir Hefetz ,  Yoel Sefi

发明人： Yehoshua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Gilad Lavi ,  Meir Hefetz ,  Yoel Sefi

IPC分类号： A61B17/34

CPC分类号： A61B17/205 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2010/0225 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003

摘要： A microneedle device for delivery or sampling of fluids to or from intradermal layers of the skin of a mammalian subject includes a skin contact configuration defining an orientation of the device and a number of microneedles The microneedles are deployed relative to the skin contact configuration so that, when deployed against the skin, a first region of a peripheral surface of the microneedle is deployed roughly parallel to the initial plane of the skin. A fluid flow bore intersects the first region of the peripheral surface.

摘要翻译： 用于将流体递送或取样到哺乳动物受试者皮肤的皮内层的微针装置包括限定装置的方向和多个微针的皮肤接触构型相对于皮肤接触构造展开微针， 当相对于皮肤展开时，微针的外周表面的第一区域大致平行于皮肤的初始平面展开。 流体流动孔与周边表面的第一区域相交。

公开(公告)号：US20090012494A1

公开(公告)日：2009-01-08

申请号：US11946889

申请日：2007-11-29

申请人： Yehoshua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Gilad Lavi ,  Meir Hefetz ,  Yoel Sefi ,  Richard Ian Catchpole

发明人： Yehoshua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Gilad Lavi ,  Meir Hefetz ,  Yoel Sefi ,  Richard Ian Catchpole

IPC分类号： A61M5/32 ,  A61K33/00 ,  A61K38/09 ,  A61K38/22 ,  A61K31/70 ,  A61K31/7105 ,  A61K31/485 ,  A61K38/47 ,  A61K38/16 ,  A61K38/28 ,  A61K38/21 ,  A61K38/20 ,  A61K31/4748 ,  A61K31/727 ,  A61K31/166 ,  A61K31/551 ,  A61K39/395 ,  A61K31/465 ,  A61K31/702 ,  A61K31/4178 ,  A61K31/137 ,  A61K39/12 ,  A61K39/00 ,  A61K39/02 ,  A61K39/235 ,  A61K39/21 ,  A61K39/155 ,  A61K39/285 ,  A61K39/145 ,  A61K39/245 ,  A61K39/295 ,  A61P43/00

CPC分类号： A61M37/0015 ,  A61M2037/003

摘要： The present invention relates to methods for intradermally delivering one or more biologically active agents such as vaccines and therapeutic agents into the dermis layer of the skin of a subject to obtain systemic delivery or an immune response using a microneedle drug delivery device containing the agent to be delivered. The methods employ a microneedle device with a row of hollow microneedles. The microneedles penetrate the skin of the subject and assume an anchored state in which the microneedles are anchored in the skin and project laterally from the device. A pivotal motion is then performed with the device so that the skin in which the microneedles are engaged is lifted above the initial plane of the surface of the skin while the biologically active agent is delivered. The methods of the invention elicit increased humoral and/or cellular response as compared to conventional vaccine delivery routes, facilitating dose sparing.

摘要翻译： 本发明涉及将一种或多种生物活性剂如疫苗和治疗剂皮内递送到受试者皮肤的真皮层中的方法，以使用含有该试剂的微针药物递送装置获得全身递送或免疫应答 交付 该方法采用具有一排中空微针的微针装置。 微针穿透受试者的皮肤并呈现锚定状态，其中微针锚定在皮肤中并从装置横向突出。 然后使用该装置进行枢转运动，使得将微针接合的皮肤提升到皮肤表面的初始平面之上，同时递送生物活性剂。 与常规疫苗递送途径相比，本发明的方法引起体液和/或细胞反应增加，促进剂量节省。