公开(公告)号：US20130110043A1

公开(公告)日：2013-05-02

申请号：US13661059

申请日：2012-10-26

申请人： Yotam Levin

发明人： Yotam Levin

IPC分类号： A61M5/50

CPC分类号： A61M5/3243 ,  A61M5/502 ,  A61M37/0015 ,  A61M2005/3247 ,  A61M2037/0023

摘要： A microneedle intradermal drug delivery device with auto-disable functionality includes a syringe (12) having a plunger (14) displaceable along a barrel (16) and a microneedle adapter (20) with hollow microneedle(s) (22). The microneedle adapter (20) and the syringe (12) are configured for irreversible engagement such that, after attachment of the microneedle adapter (20) to the syringe (12), the microneedle adapter (20) is resistant to non-destructive manual removal from the syringe (12). Also provided are a self-locking plunger configuration (54, 56, 58) and a sliding safety shield (62).

摘要翻译： 具有自动禁用功能的微针皮内药物递送装置包括具有可沿着筒体（16）移位的柱塞（14）和具有中空微针（22）的微针适配器（20）的注射器（12）。 微针适配器（20）和注射器（12）构造成不可逆接合，使得在将微针适配器（20）附接到注射器（12）之后，微针适配器（20）能够抵抗非破坏性手动去除 从注射器（12）。 还提供有自锁柱塞构造（54,56,58）和滑动安全护罩（62）。

公开(公告)号：US07998119B2

公开(公告)日：2011-08-16

申请号：US11134411

申请日：2005-05-23

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

IPC分类号： A61M5/00

CPC分类号： A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003

摘要： A system and method for delivering fluid into a flexible biological barrier employs a microneedle structure wherein a final position of microneedles inserted into the biological barrier is generally sideways projecting from the delivery configuration instead of the conventional downwards projecting arrangement. The microneedles project from a relief surface which is distinct from a primary biological-barrier contact region of the delivery configuration, and is typically angled upwards away from the biological barrier. During insertion, the contact region is brought into contact with the biological barrier and moved parallel to the surface of the flexible biological barrier so as to generate a boundary between a stretched portion and a non-stretched portion of the barrier. Typically concurrently with this motion, the microneedles penetrate into the flexible biological barrier such that, at the end of the motion, the microneedles extend into the flexible biological barrier from the boundary region in a direction towards the non-stretched portion. Fluid is then injected through the bores of the hollow microneedles towards non-stretched portion.

摘要翻译： 用于将流体输送到柔性生物屏障的系统和方法采用微针结构，其中插入生物屏障的微针的最终位置通常从输送构型侧向突出而不是传统的向下突出的布置。 微针从与输送构型的主要生物屏障接触区域不同的浮雕表面突出，并且通常向上远离生物屏障。 在插入期间，使接触区域与生物屏障接触并平行于柔性生物屏障的表面移动，以便在屏障的拉伸部分和非拉伸部分之间产生边界。 通常与该运动同时，微针穿透柔性生物屏障，使得在运动结束时，微针从朝向非拉伸部分的方向从边界区延伸到柔性生物屏障内。 然后将流体通过中空微针的孔注射到非拉伸部分。

公开(公告)号：US20090069788A1

公开(公告)日：2009-03-12

申请号：US11719541

申请日：2005-05-19

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

IPC分类号： A61M5/32

CPC分类号： A61M37/0015 ,  A61M5/32 ,  A61M2005/341 ,  A61M2037/0023 ,  A61M2037/003

摘要： A system and method for delivering fluid into a flexible biological barrier employs a microneedle structure wherein a final position of microneedles (12) inserted into the biological barrier (14) is generally sideways projecting from. the delivery configuration instead of the conventional downwards projecting arrangement. The microneedles (12) project from a relief surface (16) which is distinct from a primary biological-barrier contact region (18, 26) of the delivery configuration, and is typically angled upwards away from the biological barrier. During insertion, the contact region (18, 26) is brought into contact with the biological barrier (14) and moved parallel to the surface of the flexible biological barrier so as to generate a boundary (20) between a stretched portion (22) and a non-stretched portion (24) of the barrier. Typically concurrently with this motion, the microneedles (12) penetrate into the flexible biological barrier such that, at the end microneedles extend into the flexible biological barrier from the boundary region (20) in a direction towards the non-stretched portion (24). Fluid is then injected through the bores of the hollow microneedles towards non-stretched portion.

摘要翻译： 用于将流体输送到柔性生物屏障的系统和方法采用微针结构，其中插入生物屏障（14）中的微针（12）的最终位置通常侧向突出。 输送配置而不是常规的向下突出布置。 微针（12）从与输送构造的主要生物屏障接触区域（18,26）不同的浮雕表面（16）突出，并且通常向上远离生物屏障。 在插入期间，接触区域（18,26）与生物屏障（14）接触并平行于柔性生物屏障的表面移动，以在拉伸部分（22）和 屏障的非拉伸部分（24）。 通常与该运动同时，微针（12）穿透柔性生物屏障，使得末端微针在朝向非拉伸部分（24）的方向上从边界区域（20）延伸到柔性生物屏障内。 然后将流体通过中空微针的孔注射到非拉伸部分。

公开(公告)号：US20090054842A1

公开(公告)日：2009-02-26

申请号：US10595859

申请日：2004-11-18

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

IPC分类号： A61M5/32

CPC分类号： A61M37/0015 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15128 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053

摘要： A microneedle device for transporting fluid through a surface of a biological barrier, the device including a fluid transport configuration, an abutment member and a displacement device. The fluid transport configuration includes a substrate having a substantially planar surface having a plurality of microneedles projecting therefrom. The abutment member has an abutment surface for abutting the biological barrier. The displacement device is configured for generating a relative lateral sliding movement between the surface of the biological barrier and the fluid transport configuration in a sliding direction of the microneedles The microneedles are arranged so that a leading microneedle defines an effective area which is effective void of another microneedle. The effective area is defined as an area marked out by translating the base area of the leading microneedle, by the height of the leading microneedle, in a direction opposite to the sliding direction.

摘要翻译： 用于输送流体通过生物屏障的表面的微针装置，该装置包括流体输送构造，抵靠构件和位移装置。 流体输送构造包括具有基本平坦表面的基底，其具有从其突出的多个微针。 抵靠构件具有用于邻接生物屏障的邻接表面。 位移装置构造成在微针的滑动方向上产生生物屏障的表面和流体输送构型之间的相对横向滑动运动。微针被布置成使得前导微针限定有效区域，其有效地与另一个无效 微针 有效面积被定义为通过将主显微针的基部区域与引导微针的高度沿与滑动方向相反的方向平移来标出的区域。

公开(公告)号：US20090012494A1

公开(公告)日：2009-01-08

申请号：US11946889

申请日：2007-11-29

申请人： Yehoshua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Gilad Lavi ,  Meir Hefetz ,  Yoel Sefi ,  Richard Ian Catchpole

发明人： Yehoshua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Gilad Lavi ,  Meir Hefetz ,  Yoel Sefi ,  Richard Ian Catchpole

IPC分类号： A61M5/32 ,  A61K33/00 ,  A61K38/09 ,  A61K38/22 ,  A61K31/70 ,  A61K31/7105 ,  A61K31/485 ,  A61K38/47 ,  A61K38/16 ,  A61K38/28 ,  A61K38/21 ,  A61K38/20 ,  A61K31/4748 ,  A61K31/727 ,  A61K31/166 ,  A61K31/551 ,  A61K39/395 ,  A61K31/465 ,  A61K31/702 ,  A61K31/4178 ,  A61K31/137 ,  A61K39/12 ,  A61K39/00 ,  A61K39/02 ,  A61K39/235 ,  A61K39/21 ,  A61K39/155 ,  A61K39/285 ,  A61K39/145 ,  A61K39/245 ,  A61K39/295 ,  A61P43/00

CPC分类号： A61M37/0015 ,  A61M2037/003

摘要： The present invention relates to methods for intradermally delivering one or more biologically active agents such as vaccines and therapeutic agents into the dermis layer of the skin of a subject to obtain systemic delivery or an immune response using a microneedle drug delivery device containing the agent to be delivered. The methods employ a microneedle device with a row of hollow microneedles. The microneedles penetrate the skin of the subject and assume an anchored state in which the microneedles are anchored in the skin and project laterally from the device. A pivotal motion is then performed with the device so that the skin in which the microneedles are engaged is lifted above the initial plane of the surface of the skin while the biologically active agent is delivered. The methods of the invention elicit increased humoral and/or cellular response as compared to conventional vaccine delivery routes, facilitating dose sparing.

摘要翻译： 本发明涉及将一种或多种生物活性剂如疫苗和治疗剂皮内递送到受试者皮肤的真皮层中的方法，以使用含有该试剂的微针药物递送装置获得全身递送或免疫应答 交付 该方法采用具有一排中空微针的微针装置。 微针穿透受试者的皮肤并呈现锚定状态，其中微针锚定在皮肤中并从装置横向突出。 然后使用该装置进行枢转运动，使得将微针接合的皮肤提升到皮肤表面的初始平面之上，同时递送生物活性剂。 与常规疫苗递送途径相比，本发明的方法引起体液和/或细胞反应增加，促进剂量节省。

公开(公告)号：US20090048557A1

公开(公告)日：2009-02-19

申请号：US12296129

申请日：2007-04-19

申请人： Yehushua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Yoel Sefi ,  Lior Wolloch

发明人： Yehushua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Yoel Sefi ,  Lior Wolloch

IPC分类号： A61B17/00 ,  A61N5/06 ,  A61M35/00

CPC分类号： A61B18/203 ,  A61B2017/320004 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2090/065 ,  A61N5/062 ,  A61N2005/0644 ,  A61N2005/0651 ,  A61N2005/0659

摘要： Method and device for therapeutic or aesthetic treatment of the skin performs a combination of dermabrasion to mechanically modify at least an outer layer of the skin in a first region and phototherapy. The device preferably employs a skin interface element with projections protruding from a substrate which is moved in a vibratory motion by a vibration generating mechanism. This is combined with an illumination system deployed to direct a therapeutically relevant dosage of light towards a surface of the skin against which the skin interface unit is in contact.

摘要翻译： 用于治疗或美学治疗皮肤的方法和装置执行皮肤磨擦的组合以在第一区域中机械修饰皮肤的外层和光疗。 该装置优选采用具有从基板突出的突起的皮肤界面元件，该基板通过振动产生机构以振动运动而移动。 这与照明系统相结合，所述照明系统被部署以将治疗相关剂量的光引向皮肤接触单元所接触的皮肤表面。

公开(公告)号：US20050165358A1

公开(公告)日：2005-07-28

申请号：US10506904

申请日：2003-03-04

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yotam Levin

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yotam Levin

IPC分类号： A61M5/42 ,  A61M37/00 ,  A61M5/00

CPC分类号： A61M37/0015 ,  A61M5/425 ,  A61M2037/0023 ,  A61M2037/0038

摘要： A device (10) and method for tranporting fluids across biological barriers enhances penetration of a biological barrier by the use of directional insertion, preferably with asymmetric microneedles (18) and/or microneedles (18) with sharp edges. Additionally, or alternatively, adhesion followed by alteration of contact geometry is employed to stretch the biological barrier across the microneedles (18), thereby also enhancing penetration. Also disclosed is a device (10) and method which combine shallow penetration by hollow microneedles (18) with jet injection via the microneedles (18) to achieve a total liquid penetration depth greater than the mechanical penetration depth of the microneedles (18).

摘要翻译： 用于在生物屏障之间传输流体的装置（10）和方法通过使用定向插入，优选地具有尖锐边缘的不对称微针（18）和/或微针（18）来增强生物屏障的穿透。 另外，或者替代地，采用接触几何形状改变的粘合来拉伸穿过微针（18）的生物屏障，从而也增强渗透。 还公开了一种装置（10）和方法，其通过空心微针（18）通过微针（18）与喷射射流组合浅穿透，以实现大于微针（18）的机械穿透深度的总液体穿透深度。

公开(公告)号：US20110282298A1

公开(公告)日：2011-11-17

申请号：US13133710

申请日：2009-12-09

申请人： Nadav Agian ,  Yonni Shem-Tov ,  Barak Panga ,  Yoel Sefi ,  Yotam Levin

发明人： Nadav Agian ,  Yonni Shem-Tov ,  Barak Panga ,  Yoel Sefi ,  Yotam Levin

IPC分类号： A61M5/31 ,  A61M5/315 ,  B32B37/00 ,  A61M5/32

CPC分类号： A61M37/0015 ,  A61M5/1782 ,  A61M5/3202 ,  A61M5/344 ,  A61M5/347 ,  A61M2005/3107 ,  A61M2005/3132 ,  A61M2005/31516 ,  Y10T156/10

摘要： An injection system applicable to off-the-shelf syringes having a microneedle hub may reduce dead space and isolate the drug fluid from the microneedle chip to avoid compatibility issues. An insert may be disposed inside a male luer fitting and extend so that it is also disposed inside the female luer fitting using an insert. A septum may isolate the drug fluid from the microneedle chip in the hub prior to activation and the septum may, after activation, seal the triangular space in the hub to prevent leakage of fluid back to the syringe.

摘要翻译： 适用于具有微针毂的现成注射器的注射系统可减少死空间并将药物流体与微针芯片隔离以避免兼容性问题。 插入件可以设置在阳鲁尔接头内部并且延伸，使得其也使用插入件设置在阴鲁尔接头内部。 间隔可以在活化之前将药液从微型芯片中分离出来，并且在活化之后，隔膜可密封轮毂中的三角形空间以防止流体回流到注射器。

公开(公告)号：US20110238038A1

公开(公告)日：2011-09-29

申请号：US13132930

申请日：2009-12-03

申请人： Yoel Sefi ,  Yotam Levin ,  Yehoshua Yeshurun ,  Nadav Agian

发明人： Yoel Sefi ,  Yotam Levin ,  Yehoshua Yeshurun ,  Nadav Agian

IPC分类号： A61M5/46

CPC分类号： A61M5/46 ,  A61M5/162 ,  A61M5/30 ,  A61M5/3293 ,  A61M5/3298 ,  A61M2005/341 ,  A61M2005/342

摘要： An intradermal mini-needle interface has a penetration limiter providing a skin contact edge and a hollow hypodermic needle having a beveled penetrating portion protruding forward beyond the skin contact edge by no more than 3 mm. At least one skin contact surface defines a skin contact plane parallel to, or at a shallow angle to, the needle axis. The skin contact plane intersects the skin contact edge substantially at a base of the penetrating portion. Preferably, the penetration limiter is asymmetric under rotation about the needle axis.

摘要翻译： 皮内微针接口具有提供皮肤接触边缘的穿透限制器和具有向上突出超过皮肤接触边缘的不大于3mm的斜面穿透部分的中空皮下注射针。 至少一个皮肤接触表面限定与针轴平行或以较小角度的皮肤接触平面。 皮肤接触面基本上在穿透部分的基部与皮肤接触边缘相交。 优选地，穿透限制器围绕针轴线旋转是不对称的。

公开(公告)号：US20090247953A1

公开(公告)日：2009-10-01

申请号：US12096028

申请日：2006-12-10

申请人： Yehoshua Yeshurun ,  Yotam Levin ,  Meir Hefetz ,  Yoel Sefi ,  Gilad Lavi

发明人： Yehoshua Yeshurun ,  Yotam Levin ,  Meir Hefetz ,  Yoel Sefi ,  Gilad Lavi

IPC分类号： A61M5/32

CPC分类号： A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003

摘要： An adapter for achieving intradermal dosed delivery of a liquid by use of a dosed drug delivery device including a reservoir having a pierceable septum, the adapter having a connector including an attachment configuration for attachment to the dosed drug delivery device and a hollow needle deployed for piercing the septum. A liquid delivery interface, linked to the connector, includes a straight skin contact edge and one or more hollow microneedle adjacent thereto. The microneedle projects away from the skin contact edge. A flow path arrangement interconnects the needle and the at least one hollow microneedle.

摘要翻译： 一种用于通过使用包含具有可刺穿隔膜的储存器的剂量药物递送装置来实现液体的皮内剂量输送的适配器，所述适配器具有连接器，所述连接器包括用于附接到定量给药的药物输送装置的附接结构，以及用于刺穿 隔膜。 连接到连接器的液体传送界面包括直的皮肤接触边缘和与其相邻的一个或多个中空微针。 微针远离皮肤接触边缘。 流路布置使针和至少一个中空微针相互连接。