Patent search ap:("10X Genomics Page Inc.") AND inv:"Bill Kengli Lin"

1.

发明申请
METHODS AND SYSTEMS FOR DROPLET-BASED SINGLE CELL BARCODING 有权

公开(公告)号：US20250146181A1

公开(公告)日：2025-05-08

申请号：US19016998

申请日：2025-01-10

Applicant: 10x Genomics, Inc.

Inventor： Zahra Kamila Belhocine , Rajiv Bharadwaj , Christopher Hindson , Michael Schnall-Levin , Bill Kengli Lin , Anthony Makarewicz , Pranav Patel , Katherine Pfeiffer , Andrew D. Price , Mohammad Rahimi Lenji , Tobias Daniel Wheeler , Yifeng Yin

IPC: C40B30/04 , C07K14/74 , C12N15/10 , C12N15/11 , C12N15/85 , C12Q1/6804 , C12Q1/6806 , C12Q1/6818 , C12Q1/6827 , C12Q1/6881 , C40B50/06 , C40B70/00 , G01N33/50 , G01N33/53 , G01N33/532 , G01N33/543 , G01N33/548 , G01N33/569 , G01N33/58

Abstract: Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.

2.

发明授权
Methods and systems for analysis 有权

公开(公告)号：US12264411B2

公开(公告)日：2025-04-01

申请号：US18593788

申请日：2024-03-01

Applicant: 10x Genomics, Inc.

Inventor： Zahra Kamila Belhocine , Rajiv Bharadwaj , Christopher Hindson , Michael Schnall-Levin , Bill Kengli Lin , Anthony Makarewicz , Pranav Patel , Katherine Pfeiffer , Andrew D. Price , Mohammad Rahimi Lenji , Tobias Wheeler , Yifeng Yin

IPC: C40B30/04 , C07K14/74 , C12N15/10 , C12N15/11 , C12N15/85 , C12Q1/6804 , C12Q1/6806 , C12Q1/6818 , C12Q1/6827 , C12Q1/6881 , C40B50/06 , G01N33/50 , G01N33/53 , G01N33/532 , G01N33/543 , G01N33/548 , G01N33/569 , G01N33/58 , C40B70/00

Abstract: Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.

3.

发明公开
SAMPLE HANDLING APPARATUS AND FLUID DELIVERY METHODS 审中-公开

公开(公告)号：US20240033743A1

公开(公告)日：2024-02-01

申请号：US18245855

申请日：2021-09-17

Applicant: 10x Genomics, Inc.

Inventor： Augusto Manuel Tentori , Hanyoup Kim , Siyuan Xing , Rajiv Bharadwaj , Bill Kengli Lin , Felice Alessio Bava , Pratomo Putra Alimsijah , Hendricus Marindra , Spontaneous Rose Mcknight Russell , Nabil Mikhaiel

IPC: B01L9/00

CPC classification number: B01L9/52 , B01L2200/025 , B01L2300/027 , B01L2300/0822 , B01L2300/1883 , B01L7/52

Abstract: A sample holder is provided. The sample holder includes a first member including a first retaining mechanism configured to retain a first substrate comprising a sample. The first retaining mechanism configured to retain the first substrate disposed in a first plane. The sample holder further includes a second member including a second retaining mechanism configured to retain a second substrate including a reagent medium disposed in a second plane. The sample holder further includes an alignment mechanism connected to one or both of the first member and the second member. The alignment mechanism configured to align the first and second members along the first plane and/or the second plane such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned and within a threshold distance along an axis orthogonal to the second plane.

4.

发明授权
Devices, systems, and kits for forming droplets 有权

公开(公告)号：US10821442B2

公开(公告)日：2020-11-03

申请号：US15977812

申请日：2018-05-11

Applicant: 10X Genomics, Inc.

Inventor： Rajiv Bharadwaj , Anthony Makarewicz , Bill Kengli Lin

IPC: B01L3/02 , B01L3/00 , B01F5/04 , G01N33/543 , B01F3/08 , B01F13/00 , B01F11/02 , C12Q1/6806 , G01N33/58 , C12Q1/686 , C40B40/06

Abstract: Devices, systems, and their methods of use, for generating droplets are provided. One or more geometric parameters of a microfluidic channel can be selected to generate droplets of a desired and predictable droplet size.

5.

发明申请
METHODS AND SYSTEMS FOR ANTIGEN SCREENING 审中-公开

公开(公告)号：US20190383798A1

公开(公告)日：2019-12-19

申请号：US16375110

申请日：2019-04-04

Applicant: 10X Genomics, Inc.

Inventor： Kamila Belhocine , Jason Bell , Zachary Bent , Rajiv Bharadwaj , Christopher Hindson , Mohammad Rahimi Lenji , Bill Kengli Lin , Anthony Makarewicz , Geoffrey McDermott , Elliott Meer , Francesca Meschi , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Michael Schnall-Levin , Sarah Taylor , Jessica Michele Terry , Tobias Daniel Wheeler , Yifeng Yin , Xinying Zheng , Solongo Batjargal Ziraldo , Eswar Prasad Ramachandran Iyer , Luigi Jhon Alvarado Martinez

IPC: G01N33/50 , G01N33/543 , G01N33/53 , G01N33/569 , C12N15/10

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and antigen screening. Polynucleotide processing may be useful for a variety of applications. Antigen screening may comprise the use of one or more engineered cells. Engineered cells may be useful for characterizing one or more analytes including, for example, a polypeptide antigen.

6.

发明授权
Method of producing emulsions 有权

公开(公告)号：US10357771B2

公开(公告)日：2019-07-23

申请号：US15977861

申请日：2018-05-11

Applicant: 10X Genomics, Inc.

Inventor： Rajiv Bharadwaj , Anthony Makarewicz , Bill Kengli Lin

IPC: B01L3/00 , G01N1/00 , B01F13/00 , B01F3/08 , C12Q1/686

Abstract: Devices, systems, and their methods of use, for generating droplets are provided. One or more geometric parameters of a microfluidic channel can be selected to generate droplets of a desired and predictable droplet size.

7.

发明授权
In situ spatial barcoding 有权

公开(公告)号：US12281357B1

公开(公告)日：2025-04-22

申请号：US17174961

申请日：2021-02-12

Applicant: 10x Genomics, Inc.

Inventor： Augusto Manuel Tentori , Rajiv Bharadwaj , Bill Kengli Lin , Hanyoup Kim , Denis Pristinski

IPC: C12Q1/6876 , C12Q1/6841

Abstract: Provided herein are materials and methods for in situ labeling of a biological sample for use in spatial analysis of one or more analytes in the biological sample. In some aspects, in situ labeling of a biological sample includes labeling the biological sample with one or more spatial barcodes.