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公开(公告)号：US09987633B2
公开(公告)日：2018-06-05
申请号：US15309505
申请日：2015-06-08
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Stephen B. Roscoe , Myungchan Kang , Evan D. Brutinel , Jesse D. Miller , Renee K. Cline , Minghua Dai , Hsi-Chou Liu
CPC classification number: B01L3/5029 , B01L3/502 , B01L2200/16 , B01L2300/0825 , B01L2400/0406 , B01L2400/0478 , G01N33/5304
Abstract: Assay devices are provided including a receptacle having a sample entry port; a plunger disposed within the receptacle; at least one reagent; a membrane attached to a first surface of the plunger; a wick providing capillary force; and a detection zone. The membrane includes a target conjugate zone in which affinity components are disposed. Capture compounds are immobilized in a detection zone, which is located between the target conjugate zone and the wick. A method of detecting a target analyte is also provided, including providing the assay device; providing a sample suspected to contain a target analyte; adding the sample onto the device; allowing the sample to travel along the membrane until the sample reaches the detection zone; immobilizing the target analyte through reaction of the target analyte with the capture compounds; reacting the immobilized target analyte with a reagent to generate a detectable signal; and detecting the generated signal.
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公开(公告)号：US20170128935A1
公开(公告)日：2017-05-11
申请号：US15309505
申请日：2015-06-08
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Stephen B. Roscoe , Myungchan Kang , Evan D. Brutinel , Jesse D. Miller , Renee K. Cline , Minghua Dai , Hsi-Chou Liu
CPC classification number: B01L3/5029 , B01L3/502 , B01L2200/16 , B01L2300/0825 , B01L2400/0406 , B01L2400/0478 , G01N33/5304
Abstract: Assay devices are provided including a receptacle having a sample entry port; a plunger disposed within the receptacle; at least one reagent; a membrane attached to a first surface of the plunger; a wick providing capillary force; and a detection zone. The membrane includes a target conjugate zone in which affinity components are disposed. Capture compounds are immobilized in a detection zone, which is located between the target conjugate zone and the wick. A method of detecting a target analyte is also provided, including providing the assay device; providing a sample suspected to contain a target analyte; adding the sample onto the device; allowing the sample to travel along the membrane until the sample reaches the detection zone; immobilizing the target analyte through reaction of the target analyte with the capture compounds; reacting the immobilized target analyte with a reagent to generate a detectable signal; and detecting the generated signal.
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公开(公告)号：US20180243737A1
公开(公告)日：2018-08-30
申请号：US15962391
申请日：2018-04-25
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Stephen B. Roscoe , Myungchan Kang , Evan D. Brutinel , Jesse D. Miller , Renee K. Cline , Minghua Dai , Hsi-Chou Liu
CPC classification number: B01L3/5029 , B01L3/502 , B01L2200/16 , B01L2300/0825 , B01L2400/0406 , B01L2400/0478 , G01N33/5304
Abstract: Assay devices are provided including a receptacle having a sample entry port; a plunger disposed within the receptacle; at least one reagent; a membrane attached to a first surface of the plunger; a wick providing capillary force; and a detection zone. The membrane includes a target conjugate zone in which affinity components are disposed. Capture compounds are immobilized in a detection zone, which is located between the target conjugate zone and the wick. A method of detecting a target analyte is also provided, including providing the assay device; providing a sample suspected to contain a target analyte; adding the sample onto the device; allowing the sample to travel along the membrane until the sample reaches the detection zone; immobilizing the target analyte through reaction of the target analyte with the capture compounds; reacting the immobilized target analyte with a reagent to generate a detectable signal; and detecting the generated signal.
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