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    APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT
    2.
    发明申请
    APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 失效
    APO A-I MIME技术和治疗方法

    公开(公告)号：US20130156850A1

    公开(公告)日：2013-06-20

    申请号：US13774464

    申请日：2013-02-22

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny

    IPC: A61K38/17 ,  A61K38/10

    CPC classification number: A61K38/17 ,  A61K31/661 ,  A61K38/10 ,  A61K38/1709

    Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.

    Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将合成的载脂蛋白A-1（Apo A-I）模拟肽引入特定区域的血管壁，其中该肽具有使肽在反向胆固醇转运中有效的性质。 包含合适的载脂蛋白AI（Apo AI）模拟肽或Apo AI合成肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与内源性Apo AI相关肽的顺序相反的顺序。 一种组合物，其包含适于递送至血管的形式的载脂蛋白A-1（Apo AI）合成肽，所述肽包含相对于内源性Apo AI具有较少氨基酸残基的氨基酸主链和螺旋1的嵌合体， Apo AI的螺旋9。

    Apo A-I mimetic peptides and methods of treatment
    4.
    发明授权
    Apo A-I mimetic peptides and methods of treatment 失效
    Apo A-I模拟肽和治疗方法

    公开(公告)号：US08748394B2

    公开(公告)日：2014-06-10

    申请号：US13774464

    申请日：2013-02-22

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny

    IPC: A61K38/16 ,  A61K38/10 ,  C07K7/00 ,  C07K14/00

    CPC classification number: A61K38/17 ,  A61K31/661 ,  A61K38/10 ,  A61K38/1709

    Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.

    Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将合成的载脂蛋白A-1（Apo A-I）模拟肽引入特定区域的血管壁，其中该肽具有使肽在反向胆固醇转运中有效的性质。 包含合适的载脂蛋白AI（Apo AI）模拟肽或Apo AI合成肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与内源性Apo AI相关肽的顺序相反的顺序。 一种组合物，其包含适于递送至血管的形式的载脂蛋白A-1（Apo AI）合成肽，所述肽包含相对于内源性Apo AI具有较少氨基酸残基的氨基酸主链和螺旋1的嵌合体， Apo AI的螺旋9。

    SEQUENTIALLY INFLATABLE BALLOONS FOR DELIVERY OF TREATMENT AGENTS
    5.
    发明申请
    SEQUENTIALLY INFLATABLE BALLOONS FOR DELIVERY OF TREATMENT AGENTS 审中-公开
    用于递送治疗剂的顺序可充气气球

    公开(公告)号：US20140343536A1

    公开(公告)日：2014-11-20

    申请号：US14451086

    申请日：2014-08-04

    Applicant: Abbott Cardiovascular Systems, Inc.

    Inventor： Philip C. Foreman ,  Katsuyuki Murase

    IPC: A61M25/10

    CPC classification number: A61M25/1011 ,  A61M25/1002 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1059 ,  A61M2025/1068 ,  A61M2025/1072

    Abstract: An apparatus including a cannula having a dimension suitable for insertion into a blood vessel and an expandable body coupled thereto, the expandable body comprising a first expandable member and a second expandable member to isolate a length of the vessel upon expansion within the blood vessel. The expandable body having an intermediate expandable member along a working length between the first expandable member and the second expandable. A method including introducing a cannula and an expandable body coupled thereto into a blood vessel at a point coextensive with a treatment site and expanding a first expandable member and a second expandable member of the expandable body to isolate a length of the vessel adjacent the treatment site. The method further including delivering a treatment agent to a vessel region between the first expandable member and the second expandable member while inflating and deflating an intermediate expandable member.

    Abstract translation: 一种包括具有适于插入血管的尺寸的套管和与其连接的可膨胀体的装置，所述可膨胀体包括第一可膨胀构件和第二可膨胀构件，以在血管内扩张时隔离血管的长度。 所述可膨胀体具有沿所述第一可膨胀构件和所述第二可膨胀构件之间的工作长度的中间可膨胀构件。 一种方法，包括将与其连接的套管和可扩张体引入到与治疗部位共同延伸的点处的血管中，并且扩张可膨胀体的第一可扩张构件和第二可膨胀构件，以隔离邻近治疗部位的血管的长度 。 所述方法还包括将处理剂递送到第一可膨胀构件和第二可膨胀构件之间的容器区域，同时使中间可膨胀构件膨胀和放气。

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