公开(公告)号：US20220214362A1

公开(公告)日：2022-07-07

申请号：US17609995

申请日：2020-05-08

Applicant: ABBOTT LABORATORIES ,  GENERAL ELECTRIC COMPANY

Inventor： Beth McQuiston ,  Luca Marinelli ,  Saul Datwyler

IPC: G01N33/68

Abstract: Disclosed herein are methods that aid in the determination of whether to perform one or more advanced magnetic resonance imaging (MRI) procedures for a head injury by determining the presence or amount of one or more biomarkers in a sample obtained from the human subject. Also disclosed are methods of aiding in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, e.g., by assessing biomarker levels in combination with advanced MRI procedures. Further, also disclosed are methods of predicting or aiding in the prediction of the outcome of human subjects that have suffered a traumatic brain injury (TBI) as well as determining the course of treatment or efficacy of a course of treatment for a human subject who has suffered a TBI, e.g., by assessing biomarker levels in combination with advanced MRI procedures.

公开(公告)号：US20150073264A1

公开(公告)日：2015-03-12

申请号：US14025509

申请日：2013-09-12

Applicant: General Electric Company

Inventor： Michael Dominic Graziani ,  Thomas Kwok-Fah Foo ,  Luca Marinelli

IPC: A61B5/06

CPC classification number: A61B5/062 ,  A61B5/0515

Abstract: Magnetic material imaging (MMI) system including a first array of elongated wire segments that extend substantially parallel to an imaging plane. The imaging plane is configured to extend through a region-of-interest (ROI) of an object. The MMI system also includes a second array of elongated wire segments that extend substantially parallel to the imaging plane. The first and second arrays of wire segments are spaced apart with the imaging plane therebetween. The first and second arrays of wire segments form segment pairs. Each segment pair includes a wire segment of the first array and a wire segment of the second array, wherein the wire segments substantially coincide along a segment plane. The MMI system also includes a phase-control module configured to control a flow of current through the wire segments of the segment pairs to generate and move a one-dimensional field free region (1D FFR) within the imaging plane.

Abstract translation: 磁性材料成像（MMI）系统包括基本上平行于成像平面延伸的细长线段的第一阵列。 成像平面被配置为延伸通过对象的感兴趣区域（ROI）。 MMI系统还包括基本上平行于成像平面延伸的细长线段的第二阵列。 线段的第一和第二阵列与它们之间的成像平面间隔开。 线段的第一和第二阵列形成段对。 每个段对包括第一阵列的线段和第二阵列的线段，其中线段基本上沿着线段平行重合。 MMI系统还包括相位控制模块，该相位控制模块被配置为控制通过分段对的线段的电流的流动，以在成像平面内产生和移动一维无场区域（1D FFR）。

公开(公告)号：US10324154B2

公开(公告)日：2019-06-18

申请号：US14711650

申请日：2015-05-13

Applicant: General Electric Company

Inventor： Jonathan Immanuel Sperl ,  Christopher Judson Hardy ,  Luca Marinelli ,  Marion Irene Menzel ,  Ek Tsoon Tan

IPC: G01R33/56 ,  G01R33/563

Abstract: A magnetic resonance imaging method includes generating spatially resolved fiber orientation distributions (FODs) from magnetic resonance signals acquired from a patient tissue using a plurality of diffusion encodings, each acquired magnetic resonance signal corresponding to one of the diffusion encodings and being representative of a three-dimensional distribution of displacement of magnetic spins of gyromagnetic nuclei present in each imaging voxel. Generating the spatially resolved FODs includes performing generalized spherical deconvolution using the acquired magnetic resonance signals and a modeled tissue response matrix (TRM) to reconstruct the spatially resolved FODs. The method also includes using the spatially resolved FODs to generate a representation of fibrous tissue within the patient tissue.

公开(公告)号：US09846206B2

公开(公告)日：2017-12-19

申请号：US13970339

申请日：2013-08-19

Applicant: General Electric Company

Inventor： Dominic Michael Graziani ,  Thomas Kwok-Fah Foo ,  Luca Marinelli ,  Daniel Eugene Meyer ,  Bruce Allan Hay

IPC: G01N27/72 ,  A61B5/00 ,  G01R33/12 ,  A61B5/05

CPC classification number: G01R33/1276 ,  A61B5/00 ,  A61B5/0515

Abstract: Magnetic material imaging (MMI) system including first and second sets of field-generating coils. Each of the field-generating coils of the first and second sets has an elongated segment that extends along an imaging axis of the medical imaging system. The imaging axis extends through a region-of-interest (ROI) of an object. The elongated segments of the first set of field-generating coils are positioned opposite the elongated segments of the second set of field-generating coils and the ROI is located between the first and second sets of field-generating coils. The MMI system also includes a coil-control module configured to control a flow of current through the first and second sets of field-generating coils to generate a selection field and to generate a drive field. The selection and drive fields combine to form a movable 1D field free region (FFR) that extends through the ROI.

公开(公告)号：US09208587B2

公开(公告)日：2015-12-08

申请号：US14261623

申请日：2014-04-25

Applicant: General Electric Company

Inventor： Christopher Judson Hardy ,  Luca Marinelli ,  Marion Irene Menzel ,  Ek Tsoon Tan ,  Jonathan Immanuel Sperl

IPC: G06K9/00 ,  G06T11/00 ,  G06T7/00

CPC classification number: G06T11/006 ,  G01R33/4826 ,  G01R33/5611 ,  G01R33/56341 ,  G06T7/0012 ,  G06T2207/10088 ,  G06T2207/20056

Abstract: A method of compressed sensing for multi-shell magnetic resonance imaging includes obtaining magnetic resonance imaging data, the data being sampled along multi-shell spherical coordinates, the spherical coordinates coincident with a plurality of spokes that converge at an origin, constructing a symmetric shell for each respective sampled multi-shell to create a combined set of data, performing a three-dimensional Fourier transform on the combined set of data to reconstruct an image, and de-noising the reconstructed image by iteratively applying a sparsifying transform on non-sampled data points of neighboring shells. The method can also include randomly under-sampling the imaging data to create missing data points. A system configured to implement the method and a non-transitory computer readable medium are also disclosed.

Abstract translation: 一种用于多壳磁共振成像的压缩感测方法包括：获得磁共振成像数据，所述数据沿着多壳球面坐标进行采样，所述球面坐标与在原点收敛的多个辐条重合，构成对称壳体 每个相应的采样多壳以产生一组组合数据，对该组合数据进行三维傅里叶变换以重构图像，并通过对非采样数据迭代地应用稀疏变换来对重构图像进行去噪 相邻炮弹点。 该方法还可以包括随机对取样数据进行低采样以创建丢失的数据点。 还公开了一种被配置为实现该方法的系统和一种非暂时计算机可读介质。

公开(公告)号：US20140312897A1

公开(公告)日：2014-10-23

申请号：US13866820

申请日：2013-04-19

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Ek Tsoon Tan ,  Christopher Judson Hardy ,  Kevin Franklin King ,  Zachary William Slavens ,  Luca Marinelli ,  Robert Marc Lebel

IPC: G01R33/565

CPC classification number: G01R33/56581 ,  G01R33/56341 ,  G01R33/56572

Abstract: Systems and methods for correcting magnetic resonance (MR) data are provided. One method includes receiving the MR data and correcting errors present in the MR data due to non-uniformities in magnetic field gradients used to generate the diffusion weighted MR signals. The method also includes correcting errors present in the MR data due to concomitant gradient fields present in the magnetic field gradients by using one or more gradient terms. At least one of the gradient terms is corrected based on the correction of errors present in the MR data due to the non-uniformities in the magnetic field gradients.

Abstract translation: 提供了用于校正磁共振（MR）数据的系统和方法。 一种方法包括由于用于产生扩散加权MR信号的磁场梯度中的不均匀性，接收MR数据并校正MR数据中存在的错误。 该方法还包括通过使用一个或多个梯度项来校正存在于磁场梯度中的伴随的梯度场的MR数据中存在的误差。 由于磁场梯度中的不均匀性，基于MR数据中存在的误差的校正来校正至少一个梯度项。

公开(公告)号：US20140185894A1

公开(公告)日：2014-07-03

申请号：US13728871

申请日：2012-12-27

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Marion Irene Menzel ,  Christopher Judson Hardy ,  Kevin Franklin King ,  Luca Marinelli ,  Ek Tsoon Tan ,  Jonathan Immanuel Sperl

IPC: G06T7/00

CPC classification number: G01R33/56341

Abstract: A magnetic resonance (MR) imaging method includes acquiring MR signals having phase and magnitude at q-space locations using a diffusion sensitizing pulse sequence performed on a tissue of interest, wherein the acquired signals each include a set of complex Fourier encodings representing a three-dimensional displacement distribution of the spins in a q-space location. The signals each include information relating to coherent motion and incoherent motion in the q-space location. The method also includes determining a contribution by coherent motion to the phase of the acquired MR signals; removing the phase contribution attributable to coherent motion from the acquired MR signals to produce a complex data set for each q-space location and an image of velocity components for each q-space location; and producing a three-dimensional velocity image from the image of the velocity components.

Abstract translation: 磁共振（MR）成像方法包括使用在感兴趣的组织上执行的扩散增感脉冲序列获取在q空间位置具有相位和幅度的MR信号，其中所获取的信号各自包括一组代表三维空间的复数傅里叶编码， 在q空间位置的自旋的三维位移分布。 每个信号包括与q空间位置中的相干运动和非相干运动有关的信息。 该方法还包括通过相干运动确定所获取的MR信号的相位的贡献; 从所获取的MR信号去除归因于相干运动的相位贡献，以产生用于每个q空间位置的复数数据集和用于每个q空间位置的速度分量的图像; 并根据速度分量的图像产生三维速度图像。

公开(公告)号：US20200297219A1

公开(公告)日：2020-09-24

申请号：US16357023

申请日：2019-03-18

Applicant: General Electric Company

Inventor： Jhimli Mitra ,  Luca Marinelli ,  Asha Singanamalli

IPC: A61B5/02 ,  G06N3/08 ,  G06N20/00 ,  A61B5/00 ,  A61B8/08

Abstract: In accordance with the present disclosure, deep-learning techniques are employed to find anomalies corresponding to bleed events. By way of example, a deep convolutional neural network or combination of such networks may be trained to determine the location of a bleed event, such as an internal bleed event, based on ultrasound data acquired at one or more locations on a patient anatomy. Such a technique may be useful in non-clinical settings.

公开(公告)号：US20200245967A1

公开(公告)日：2020-08-06

申请号：US16267147

申请日：2019-02-04

Applicant: General Electric Company

Inventor： Prem Venugopal ,  Luca Marinelli

IPC: A61B8/06 ,  A61B8/08 ,  A61B5/02

Abstract: The present disclosure relates to localization of bleeds (e.g., arterial bleed events) using a limited or minimal number of ultrasound scans. In one implementation, Doppler ultrasound is used to measure blood flow velocities in a one-dimensional (1D) arterial tree model to determine the location and size of bleed. In a second implementation, ultrasound measured waveforms for blood flow velocity and vessel cross-sectional area are de-composed. The features in the de-composed waveforms are then used to locate the bleed using a trained algorithm.

公开(公告)号：US09211083B2

公开(公告)日：2015-12-15

申请号：US14025509

申请日：2013-09-12

Applicant: General Electric Company

Inventor： Michael Dominic Graziani ,  Thomas Kwok-Fah Foo ,  Luca Marinelli

IPC: A61B5/06 ,  A61B5/05

CPC classification number: A61B5/062 ,  A61B5/0515

Abstract: Magnetic material imaging (MMI) system including a first array of elongated wire segments that extend substantially parallel to an imaging plane. The imaging plane is configured to extend through a region-of-interest (ROI) of an object. The MMI system also includes a second array of elongated wire segments that extend substantially parallel to the imaging plane. The first and second arrays of wire segments are spaced apart with the imaging plane therebetween. The first and second arrays of wire segments form segment pairs. Each segment pair includes a wire segment of the first array and a wire segment of the second array, wherein the wire segments substantially coincide along a segment plane. The MMI system also includes a phase-control module configured to control a flow of current through the wire segments of the segment pairs to generate and move a one-dimensional field free region (1D FFR) within the imaging plane.

Abstract translation: 磁性材料成像（MMI）系统包括基本上平行于成像平面延伸的细长线段的第一阵列。 成像平面被配置为延伸通过对象的感兴趣区域（ROI）。 MMI系统还包括基本上平行于成像平面延伸的细长线段的第二阵列。 线段的第一和第二阵列与它们之间的成像平面间隔开。 线段的第一和第二阵列形成段对。 每个段对包括第一阵列的线段和第二阵列的线段，其中线段基本上沿着线段平行重合。 MMI系统还包括相位控制模块，该相位控制模块被配置为控制通过分段对的线段的电流的流动，以在成像平面内产生和移动一维无场区域（1D FFR）。