公开(公告)号：US20240228591A1

公开(公告)日：2024-07-11

申请号：US18403419

申请日：2024-01-03

Applicant: ACADEMIA SINICA

Inventor： Kuo-I LIN ,  Che MA ,  Chi-Huey WONG ,  Szu-Wen WANG ,  Yi-Hsuan CHANG ,  Xiaorui CHEN ,  Han-Yi HUANG

IPC: C07K16/10 ,  A61K39/00 ,  A61K39/42

CPC classification number: C07K16/10 ,  A61K39/42 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-COV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.

公开(公告)号：US20240016917A1

公开(公告)日：2024-01-18

申请号：US18005573

申请日：2022-04-12

Applicant: ACADEMIA SINICA

Inventor： Che MA ,  Chi-Huey WONG ,  Han-Yi HUANG

IPC: A61K39/215 ,  A61P31/04

CPC classification number: A61K39/215 ,  A61P31/04 ,  A61K2039/55505

Abstract: The present disclosure provides a glycoengineered SARS-CoV-2 spike protein which is capable of eliciting an enhanced immune response relative to a native spike protein of SARS-CoV-2 and its variants. The glycoengineered spike protein exposes the glycosylation sites and at the same time preserves the tertiary structure of the spike protein. The present disclosure therefore provides improved immunogens, vaccines, and methods for better prevention and treatment of the emerging coronavirus infections.