公开(公告)号：US20240228591A1

公开(公告)日：2024-07-11

申请号：US18403419

申请日：2024-01-03

Applicant: ACADEMIA SINICA

Inventor： Kuo-I LIN ,  Che MA ,  Chi-Huey WONG ,  Szu-Wen WANG ,  Yi-Hsuan CHANG ,  Xiaorui CHEN ,  Han-Yi HUANG

IPC: C07K16/10 ,  A61K39/00 ,  A61K39/42

CPC classification number: C07K16/10 ,  A61K39/42 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-COV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.

公开(公告)号：US20230302114A1

公开(公告)日：2023-09-28

申请号：US17998208

申请日：2021-05-07

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey WONG ,  Hsin-Yu LIAO ,  Shih-Chi WANG ,  Yi-An KO ,  Kuo-I LIN ,  Che MA ,  Ting-Jen CHENG

IPC: A61K39/145 ,  C07K14/005 ,  A61P31/16

CPC classification number: A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US20250082744A1

公开(公告)日：2025-03-13

申请号：US18927447

申请日：2024-10-25

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey WONG ,  Hsin-Yu LIAO ,  Shih-Chi WANG ,  Yi-An KO ,  Kuo-I LIN ,  Che MA ,  Ting-Jen CHENG

IPC: A61K39/145 ,  A61K39/00 ,  A61P31/16 ,  C07K14/005

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US20230279080A1

公开(公告)日：2023-09-07

申请号：US18146873

申请日：2022-12-27

Applicant: ACADEMIA SINICA

Inventor： Kuo-I LIN ,  Chi-Huey WONG ,  Szu-Wen WANG ,  Yi-Hsuan CHANG

IPC: C07K16/10 ,  G01N33/569 ,  A61K45/06

CPC classification number: C07K16/10 ,  A61K45/06 ,  G01N33/56983 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/92 ,  G01N2333/165 ,  G01N2469/10

Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that is specific for a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.

公开(公告)号：US20240316179A1

公开(公告)日：2024-09-26

申请号：US18662436

申请日：2024-05-13

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey WONG ,  Hsin-Yu LIAO ,  Shih-Chi WANG ,  Yi-An KO ,  Kuo-I LIN ,  Che MA ,  Ting-Jen CHENG

IPC: A61K39/145 ,  A61K39/00 ,  A61P31/16 ,  C07K14/005

CPC classification number: A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US20240100147A1

公开(公告)日：2024-03-28

申请号：US18501578

申请日：2023-11-03

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey WONG ,  Hsin-Yu LIAO ,  Shih-Chi WANG ,  Yi-An KO ,  Kuo-I LIN ,  Che MA ,  Ting-Jen CHENG

IPC: A61K39/145 ,  A61P31/16 ,  C07K14/005

CPC classification number: A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US20210301318A1

公开(公告)日：2021-09-30

申请号：US17258826

申请日：2019-07-10

Applicant: ACADEMIA SINICA ,  BUDDHIST TZU CHI MEDICAL FOUNDATION ,  CHINA MEDICAL UNIVERSITY

Inventor： Kuo-I LIN ,  Shih-Chieh HUNG ,  Chin-Hsiu LIU

IPC: C12Q1/42 ,  G01N33/50 ,  A61K45/06 ,  A61K31/429 ,  A61K31/663 ,  G01N33/573 ,  G01N33/68 ,  C12Q1/686 ,  C12Q1/6816

Abstract: The present invention relates to a biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis (AS). The present invention also relates to a method for producing an animal model for AS, an animal model produced therefrom, and a method for screening for an agent pharmaceutically active in the treatment of A S using such animal model.