公开(公告)号：US10414809B2

公开(公告)日：2019-09-17

申请号：US15507650

申请日：2015-09-01

Applicant: ACADEMIA SINICA

Inventor： Che-Kun James Shen ,  Yu-Chiau Shyu

IPC: C07K14/47 ,  A01K67/027 ,  A61K38/17 ,  A61K45/06

Abstract: The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis.

公开(公告)号：US11266697B2

公开(公告)日：2022-03-08

申请号：US16333186

申请日：2017-09-13

Applicant: Academia Sinica

Inventor： Che-Kun James Shen ,  Yu-Chiau Shyu ,  Chun-Hao Hung

IPC: A61K35/545 ,  A61P35/00 ,  C07K14/47 ,  C12N5/0735 ,  C12N5/0775 ,  C12N5/074 ,  C12N5/0789

Abstract: The invention found that first, the feasibility of transfer of tumor resistance and other healthy longevity characters through transplantation of bone marrow mononuclear cells (BMMNC) or hematopoietic stem cells (HSC)/hematopoietic stem and progenitor cells (HSPC) consisting of genetically engineered EKLF gene encoding the hematopoietic transcription factor EKLF. Secondly, the present invention demonstrates expression of EKLF in the long-term hematopoietic stem cells (LT-HSC), and thus EKLF as a target of regulation of hematopoiesis.

公开(公告)号：US11254719B2

公开(公告)日：2022-02-22

申请号：US16519461

申请日：2019-07-23

Applicant: ACADEMIA SINICA

Inventor： Che-Kun James Shen ,  Yu-Chiau Shyu

IPC: A61K39/00 ,  C07K14/47 ,  A01K67/027 ,  A61K38/17 ,  A61K45/06

Abstract: A genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis.