公开(公告)号：US20180325111A1

公开(公告)日：2018-11-15

申请号：US15773993

申请日：2016-10-31

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Yi Yan YANG ,  QingXing XU ,  Majad KHAN ,  Chuan YANG ,  Shrinivas VENKATARAMAN

IPC: A01N43/32 ,  C02F1/50 ,  C08L79/08

CPC classification number: A01N43/32 ,  A01N33/12 ,  A01N37/44 ,  A61K47/59 ,  C02F1/50 ,  C08G73/02 ,  C08L79/08

Abstract: This invention relates to an antibacterial polymer-modified particle comprising a particle core, wherein a polymer is covalently bound to the particle core via a linker and said polymer comprises a branched, amphiphilic cationic polyalkylene imine backbone having amine or amino functional groups and wherein optionally all or some of the amine or amino groups of the polymer have been further reacted with amphiphilic cyclic carbonates carrying a quaternary ammonium group under formation of a urethane bond. In a preferred embodiment the core is a silica core functionalized with the polyelkyleneimine. The invention also relates to methods of making such particles and their use in water disinfection applications.

公开(公告)号：US20220111115A1

公开(公告)日：2022-04-14

申请号：US17264608

申请日：2019-07-30

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  NATIONAL UNIVERSITY OF SINGAPORE

Inventor： Yi Yan YANG ,  Zhen Chang LIANG ,  Chuan YANG ,  Ee Jen Wilson WANG

IPC: A61L24/06 ,  C08G64/02 ,  C08G64/18 ,  C08G64/40 ,  A61L24/00

Abstract: There is provided a bone cement composition comprising: a powder component comprising at least one acrylic polymer a liquid component comprising a monomer; an antibiotic; and an acid-functionalised polymer, wherein reaction of the powder component and the liquid component results in formation of a bone cement. In a preferred embodiment, the acid-functionalised polymer is selected from polyethylene glycol-polycarbonate (PEG-PAC), polycarbonate-poly(L-lactide) (PAC-PLLA), polycarbonate-poly(D-lactide) (PAC-PDLA), PAC-PLLA/PDLA, copolymers thereof or a combination thereof. There is also provided a bone cement formed from the bone cement composition.

公开(公告)号：US20190134210A1

公开(公告)日：2019-05-09

申请号：US15807602

申请日：2017-11-09

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Dylan BODAY ,  Wei CHENG ,  Jeannette M. GARCIA ,  James HEDRICK ,  Nathaniel H. PARK ,  Rudy J. WOJTECKI ,  Chuan YANG ,  Yi Yan YANG

IPC: A61K47/60 ,  A61P35/00 ,  A61K31/785 ,  A61K47/69

Abstract: Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block copolymer. The block copolymer can include a water-soluble block, a cationic block, and a linker, wherein the linker is connected to the water-soluble bock and the charged block.