公开(公告)号：US20190077909A1

公开(公告)日：2019-03-14

申请号：US15699416

申请日：2017-09-08

Applicant: International Business Machines Corporation ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (ASTAR)

Inventor： Dylan J. BODAY ,  Willy CHIN ,  Jeannette M. GARCIA ,  James L. HEDRICK ,  Eunice Leong JIAYU ,  Shrinivas VENKATARAMAN ,  Zhi Xiang VOO ,  Rudy J. WOJTECKI ,  Yi Yan YANG

IPC: C08G64/18 ,  C08G64/40 ,  A61K47/34

CPC classification number: C08G64/183 ,  A61K47/34 ,  C08G63/64 ,  C08G64/18 ,  C08G64/406 ,  C08G81/00

Abstract: The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.

公开(公告)号：US20170238547A1

公开(公告)日：2017-08-24

申请号：US15519534

申请日：2015-10-14

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Yi Yan YANG ,  Zhi Xiang VOO

IPC: A01N47/06 ,  C09D169/00 ,  C08G64/18 ,  C08G64/40 ,  C09D5/14 ,  A01N25/08

CPC classification number: A01N47/06 ,  A01N25/08 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L2300/404 ,  C08G64/183 ,  C08G64/30 ,  C08G64/40 ,  C08G65/48 ,  C08J7/047 ,  C08J2383/04 ,  C08J2469/00 ,  C08J2471/02 ,  C08J2485/00 ,  C08L87/005 ,  C09D5/14 ,  C09D169/00

Abstract: The present disclosure provides a copolymer comprising monomer units represented by formulas (I) and/or (II) as disclosed and defined herein which are useful in antibacterial and/or antifouling coatings. The present disclosure further provides methods of synthesizing said copolymers.