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公开(公告)号：US20150344547A1
公开(公告)日：2015-12-03
申请号：US14436002
申请日：2013-11-01
Applicant: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH
IPC: C07K16/12
CPC classification number: C07K16/12 , C07K16/1232 , C07K16/1275 , C07K16/44 , C07K2317/92 , G01N33/566 , G01N2333/4722
Abstract: Disclosed is an isolated antibody or an antigen-binding fragment thereof. The antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing the antibody, compositions comprising the antibody, methods of treating using the antibody, uses of the antibody, methods of detecting muramyl peptide, an assay for detecting muramyl peptide, an antibacterial agent, hybridomas and kits.
Abstract translation: 公开了分离的抗体或其抗原结合片段。 该抗体能够结合胞壁酰肽或其衍生物或类似物或其盐。 胞壁酰基肽包括胞壁酸和选自丙氨酸，异谷氨酰胺，谷氨酸及其盐的氨基酸。 还公开了制备抗体的方法，包含抗体的组合物，使用抗体的治疗方法，抗体的使用，检测胞壁酰肽的方法，检测胞壁酰肽的检测方法，抗菌剂，杂交瘤和试剂盒。
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公开(公告)号：US10316079B2
公开(公告)日：2019-06-11
申请号：US15600203
申请日：2017-05-19
Applicant: Agency for Science, Technology and Research
IPC: C07K16/12 , C07K16/44 , A61K39/00 , G01N33/566
Abstract: Disclosed is an isolated antibody or an antigen-binding fragment thereof The antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing the antibody, compositions comprising the antibody, methods of treating using the antibody, uses of the antibody, methods of detecting muramyl peptide, an assay for detecting muramyl peptide, an antibacterial agent, hybridomas and kits.
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公开(公告)号：US20170260259A1
公开(公告)日：2017-09-14
申请号：US15600203
申请日：2017-05-19
Applicant: Agency for Science, Technology and Research
IPC: C07K16/12 , C07K16/44 , G01N33/566
CPC classification number: C07K16/12 , C07K16/1232 , C07K16/1275 , C07K16/44 , C07K2317/92 , G01N33/566 , G01N2333/4722
Abstract: Disclosed is an isolated antibody or an antigen-binding fragment thereof The antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing the antibody, compositions comprising the antibody, methods of treating using the antibody, uses of the antibody, methods of detecting muramyl peptide, an assay for detecting muramyl peptide, an antibacterial agent, hybridomas and kits.
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公开(公告)号：US09695231B2
公开(公告)日：2017-07-04
申请号：US14436002
申请日：2013-11-01
Applicant: Agency for Science, Technology and Research
IPC: C07K16/12 , C07K16/44 , G01N33/566
CPC classification number: C07K16/12 , C07K16/1232 , C07K16/1275 , C07K16/44 , C07K2317/92 , G01N33/566 , G01N2333/4722
Abstract: Disclosed is an isolated antibody or an antigen-binding fragment thereof. The antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing the antibody, compositions comprising the antibody, methods of treating using the antibody, uses of the antibody, methods of detecting muramyl peptide, an assay for detecting muramyl peptide, an antibacterial agent, hybridomas and kits.
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