公开(公告)号：US11913064B2

公开(公告)日：2024-02-27

申请号：US16498877

申请日：2018-03-09

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Hyun-Chul Yoon ,  Jae-Ho Kim ,  Yong-Duk Han ,  Hyeong-Jin Chun

IPC: G01N21/55 ,  G02B5/126 ,  G02B5/128 ,  G02B5/12 ,  C12Q1/6825

CPC classification number: C12Q1/6825 ,  G01N21/55 ,  G02B5/126 ,  G02B5/128 ,  G01N2021/551 ,  G01N2201/0636 ,  G02B5/12 ,  C12Q1/6825 ,  C12Q2525/301 ,  C12Q2563/131 ,  C12Q2565/519 ,  C12Q2565/60

Abstract: An optical gene biosensor is disclosed. The optical gene biosensor includes a substrate; a molecular beacon anchored to the substrate, wherein the molecular beacon includes an oligonucleotide specifically binding to a target nucleic acid molecule and a first compound bound to a first terminal of the oligonucleotide; an optical marker specifically binding to the first compound, wherein the optical marker is configured to retro-reflect irradiated light; a light source for irradiating the optical marker with light; and a light-receiver for receiving light retro-reflected from the optical marker. The optical gene biosensor may perform accurate quantitative analysis of a target nucleic acid molecule using both non-spectral and spectral light sources.