公开(公告)号：US3452004A

公开(公告)日：1969-06-24

申请号：US3452004D

申请日：1966-05-19

Applicant: AMERICAN HOME PROD

Inventor： STRIKE DONALD P ,  HERBST DAVID R ,  SMITH HERCHEL

IPC: C07J1/00 ,  C07J75/00 ,  C07C169/22 ,  C07C167/00 ,  C07C169/10

CPC classification number: C07J1/00 ,  C07J75/00

公开(公告)号：US3607889A

公开(公告)日：1971-09-21

申请号：US3607889D

申请日：1966-05-19

Applicant: AMERICAN HOME PROD

Inventor： STRIKE DONALD P ,  HERBST DAVID R ,  SMITH HERCHEL

IPC: C07C169/20

Abstract: 13-Aklyl-10-methylgon-4-en-3-ones possessing androgenic, anabolic, progestational activity are prepared from the correspondingly substituted 13-alkyl-10-methylgonan-4-ones wherein groups labile to mesylation are protected to permit selective mesylation of subsequently formed 4-hydroxy group, by converting the 4-one to its 3-hydroxy-methylene derivative, hydrolyzing the oximino group, mesylating the 4-hydroxy group, catalytically hydrogenating the unsaturation at the 4-position, and eliminating the 4-mexyloxy group to form the 4-en-3-one conjugated system.

公开(公告)号：US3418343A

公开(公告)日：1968-12-24

申请号：US56137566

申请日：1966-06-29

Applicant: AMERICAN HOME PROD

Inventor： STRIKE DONALD P ,  HERCHEL SMITH

IPC: C07J1/00 ,  C07J75/00

CPC classification number: C07J1/00 ,  C07J75/00

公开(公告)号：US3912725A

公开(公告)日：1975-10-14

申请号：US47675774

申请日：1974-06-05

Applicant: AMERICAN HOME PROD

Inventor： LEEMING MICHAEL R G ,  STRIKE DONALD P ,  KAO WEN-LING

IPC: C07C405/00 ,  C07D309/06 ,  C07C69/02 ,  C07D309/22

CPC classification number: C07C405/00

Abstract: A process for the conversion of A type prostaglandins to E type prostaglandins is disclosed. Heretofore unknown prostaglandin derivatives are utilized as intermediates in the process.

Abstract translation: 公开了将A型前列腺素转化为E型前列腺素的方法。 迄今未知的前列腺素衍生物在该过程中被用作中间体。

公开(公告)号：US3407194A

公开(公告)日：1968-10-22

申请号：US58174566

申请日：1966-09-26

Applicant: AMERICAN HOME PROD

Inventor： STRIKE DONALD P ,  TELLER DANIEL M ,  SMITH HERCHEL

IPC: A61K31/565 ,  A61K31/567

CPC classification number: A61K31/567 ,  A61K31/565

公开(公告)号：US3922302A

公开(公告)日：1975-11-25

申请号：US38300773

申请日：1973-07-26

Applicant: AMERICAN HOME PROD

Inventor： STRIKE DONALD P

IPC: C07C405/00 ,  C07D317/72 ,  C07C61/38 ,  C07C69/74

CPC classification number: C07D317/72 ,  C07C405/00 ,  Y10S514/826

Abstract: 9-Oxo-15-substituted prostanoic acids, and intermediates for their preparation and for the preparation of other known prostaglandins are disclosed. The final products have bronchodilatory activity.

Abstract translation: 公开了9-氧代-15-取代的前列腺酸及其制备和制备其它已知的前列腺素的中间体。 最终产品具有支气管扩张作用。

公开(公告)号：US3919302A

公开(公告)日：1975-11-11

申请号：US44683574

申请日：1974-02-28

Applicant: AMERICAN HOME PROD

Inventor： STRIKE DONALD P ,  KAO WENLING ,  FENICHEL RICHARD L

IPC: C07C405/00 ,  C07C61/38

CPC classification number: C07C405/00

Abstract: The topical application of 7-(5 Alpha -hydroxy-2 Beta -((3RS)-3hydroxy-3-methyl-trans-1-octenyl)-3 Alpha -methyl-1 Alpha cyclopentyl)-cis-6-heptenoic acid, 7-(5 Alpha -hydroxy-2 Beta ((3RS)-3-hydroxy-3-methyl-trans-1-octenyl)-1 Alpha -cyclopentyl)cis-5-heptenoic acid, or 7-(2 Beta -((3RS)-hydroxy-3-methyltrans-1-octenyl)-5-oxo-1 Alpha -cyclopentyl)-cis-5-heptenoic acid to a wound surface can be employed to attenuate bleeding. The compounds are prepared from the prostaglandin PGA2.

Abstract translation: 7-（5α-羟基-2β - [（3RS）-3-羟基-3-甲基 - 反-1-辛烯基]-3α-甲基-1α-环戊基） - 顺式-6- 庚烯酸，7-（5α-羟基-2β - [（3RS）-3-羟基-3-甲基 - 反-1-辛烯基]-1α-环戊基） - 顺式-5-庚烯酸或7- （2β-[（3RS） - 羟基-3-甲基 - 反-1-辛烯基] -5-氧代-1α-环戊基） - 顺式-5-庚烯酸可以用于减少出血。 该化合物由前列腺素PGA2制备。