公开(公告)号：US3481917A

公开(公告)日：1969-12-02

申请号：US3481917D

申请日：1967-03-06

Applicant: AMERICAN HOME PROD

Inventor： GRANT NORMAN H ,  ALBURN HARVEY E ,  FENICHEL RICHARD L

IPC: A61K38/00 ,  C07K14/62 ,  C07G15/00 ,  A61K17/02

CPC classification number: C07K14/62 ,  A61K38/00

公开(公告)号：US3928590A

公开(公告)日：1975-12-23

申请号：US47712174

申请日：1974-06-06

Applicant: AMERICAN HOME PROD

Inventor： WOLF MILTON ,  SELLSTEDT JOHN H ,  FENICHEL RICHARD L

IPC: A61K31/40 ,  C07D295/04 ,  C07D295/10 ,  A61K27/00

CPC classification number: C07D295/10 ,  A61K31/40 ,  C07D295/04 ,  Y10S514/866

Abstract: Ortho-mercaptoaroylamides and pharmaceutically acceptable salts thereof exhibit hypoglycemic activity in warm-blooded animals. The compounds may be prepared directly by the reaction of a secondary amine with a 2-imino-1,3-benzothiazin-4-one or indirectly by the reaction of the desired amine with (ochlorocarbonylphenyl) dithioether followed by reduction of the disulfide linkage.

Abstract translation: 正 - 巯基酰基酰胺及其药学上可接受的盐在温血动物中表现出低血糖活性。 可以通过仲胺与2-亚氨基-1,3-苯并噻嗪-4-酮的反应或间接通过所需胺与（邻 - 氯羰基苯基）二硫醚的反应直接制备化合物，然后还原二硫化物 连锁。

公开(公告)号：US3475534A

公开(公告)日：1969-10-28

申请号：US3475534D

申请日：1967-01-23

Applicant: AMERICAN HOME PROD

Inventor： FENICHEL RICHARD L ,  ALBURN HARVEY E

IPC: A61K38/00 ,  C07K14/62 ,  A61K17/02

CPC classification number: C07K14/62 ,  A61K38/00 ,  Y10T436/144444

公开(公告)号：US3919302A

公开(公告)日：1975-11-11

申请号：US44683574

申请日：1974-02-28

Applicant: AMERICAN HOME PROD

Inventor： STRIKE DONALD P ,  KAO WENLING ,  FENICHEL RICHARD L

IPC: C07C405/00 ,  C07C61/38

CPC classification number: C07C405/00

Abstract: The topical application of 7-(5 Alpha -hydroxy-2 Beta -((3RS)-3hydroxy-3-methyl-trans-1-octenyl)-3 Alpha -methyl-1 Alpha cyclopentyl)-cis-6-heptenoic acid, 7-(5 Alpha -hydroxy-2 Beta ((3RS)-3-hydroxy-3-methyl-trans-1-octenyl)-1 Alpha -cyclopentyl)cis-5-heptenoic acid, or 7-(2 Beta -((3RS)-hydroxy-3-methyltrans-1-octenyl)-5-oxo-1 Alpha -cyclopentyl)-cis-5-heptenoic acid to a wound surface can be employed to attenuate bleeding. The compounds are prepared from the prostaglandin PGA2.

Abstract translation: 7-（5α-羟基-2β - [（3RS）-3-羟基-3-甲基 - 反-1-辛烯基]-3α-甲基-1α-环戊基） - 顺式-6- 庚烯酸，7-（5α-羟基-2β - [（3RS）-3-羟基-3-甲基 - 反-1-辛烯基]-1α-环戊基） - 顺式-5-庚烯酸或7- （2β-[（3RS） - 羟基-3-甲基 - 反-1-辛烯基] -5-氧代-1α-环戊基） - 顺式-5-庚烯酸可以用于减少出血。 该化合物由前列腺素PGA2制备。

公开(公告)号：US3591574A

公开(公告)日：1971-07-06

申请号：US3591574D

申请日：1968-05-29

Applicant: AMERICAN HOME PROD

Inventor： FENICHEL RICHARD L ,  GRANT NORMAN H ,  ALBURN HARVEY E

IPC: C07K14/575 ,  A61K38/28 ,  C07K1/06 ,  C07K14/62 ,  C07K14/625 ,  C07K16/00 ,  C07C103/52

CPC classification number: C07K14/625 ,  C07K1/063

Abstract: ACYL-SUBSTITUTED-INSULINS, PARTICULARLY PHENYL- AND SUBSTITUTED-PEHNYLGLYCYL-INSULINS, ESPECIALLY N-PHENYLGLYCYLINSULIN, N-P-METHYLPHENYLGLYCYL-INSULIN AND N-P-CHLOROPHENYLGLYCYL-INSULIN (1), ARE PREPARED BY TREATING INSULIN WITH AN ACYLATING AGENT, ESPECIALLY THE CORRESPONDING NCHLOROFORMYL-N-PHENYL OR SUBSTITUTED-PHENYLGLYCIN (II). THE NEW COMPOUNDS (I) HAVE HYPOGLYCEMIC ACTIVITY AND ARE USEFUL TO TREAT DIABETES, ESPECIALLY IN SUBJECTS WHO ARE INSULIN FAST.

公开(公告)号：US3881019A

公开(公告)日：1975-04-29

申请号：US40524173

申请日：1973-10-10

Applicant: AMERICAN HOME PROD

Inventor： WOLF MILTON ,  SELLSTEDT JOHN H ,  FENICHEL RICHARD L

IPC: A61K31/165 ,  C07D295/04 ,  C07D295/10 ,  A61K27/00

CPC classification number: C07D295/10 ,  A61K31/165 ,  C07D295/04 ,  Y10S514/884

Abstract: Bis(o-N-substituted carbamylphenyl) disulfides, the mercapto reduction product and pharmaceutically acceptable salts thereof exhibit hypoglycemic activity in warm-blooded animals.

Abstract translation: 双（邻-N-取代的氨基甲酰基苯基）二硫化物，巯基还原产物及其药学上可接受的盐在温血动物中表现出低血糖活性。

公开(公告)号：US3629391A

公开(公告)日：1971-12-21

申请号：US3629391D

申请日：1969-04-28

Applicant: AMERICAN HOME PROD

Inventor： FENICHEL RICHARD L ,  ALBURN HARVEY E

IPC: A61K38/00 ,  C07K14/62 ,  G01N31/00

CPC classification number: C07K14/62 ,  A61K38/00 ,  Y10T436/144444

Abstract: COMPOSITION CONTAINING REDUCED INSULIN B CHAINS COMPLEXED WITH ALBUMIA HAVE HYPERGLYCEMIC ACTIVITY AND ARE USEFUL IN THE TREATMENT OF HYPERINSULINISM, TO SCREEN SUBSTANCES WHICH ARE USEFUL IN THE TREATMENT OF DIABETES AND TO DIAGNOSE DIABETIC AND STATES IN ANIMALS.