公开(公告)号：US11033684B2

公开(公告)日：2021-06-15

申请号：US15762939

申请日：2016-10-28

Applicant: AMGEN INC.

Inventor： Hans Stenberg Knudsen ,  Christian Plambech ,  Rasmus Øhlenschlæger ,  Jørgen Jørgensen

IPC: A61M5/20 ,  A61M5/145 ,  A61M5/32 ,  A61M5/142 ,  A61M5/315

Abstract: A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.

公开(公告)号：US20250082858A1

公开(公告)日：2025-03-13

申请号：US18962542

申请日：2024-11-27

Applicant: AMGEN INC.

Inventor： Hans Stenberg Knudsen ,  Christian Plambech ,  Rasmus Øhlenschlæger ,  Jørgen Jørgensen

IPC: A61M5/20 ,  A61M5/142 ,  A61M5/145 ,  A61M5/315 ,  A61M5/32

Abstract: A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.

公开(公告)号：US12186536B2

公开(公告)日：2025-01-07

申请号：US17323830

申请日：2021-05-18

Applicant: AMGEN INC.

Inventor： Hans Stenberg Knudsen ,  Christian Plambech ,  Rasmus Øhlenschlæger ,  Jørgen Jørgensen

IPC: A61M5/20 ,  A61M5/145 ,  A61M5/32 ,  A61M5/142 ,  A61M5/315

Abstract: A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.

公开(公告)号：US20210268192A1

公开(公告)日：2021-09-02

申请号：US17323830

申请日：2021-05-18

Applicant: AMGEN INC.

Inventor： Hans Stenberg Knudsen ,  Christian Plambech ,  Rasmus Øhlenschlæger ,  Jørgen Jørgensen

IPC: A61M5/20 ,  A61M5/145 ,  A61M5/32

Abstract: A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.

公开(公告)号：US20180304014A1

公开(公告)日：2018-10-25

申请号：US15762939

申请日：2016-10-28

Applicant: AMGEN INC.

Inventor： Hans Stenberg Knudsen ,  Christian Plambech ,  Rasmus Øhlenschlæger ,  Jørgen Jørgensen

IPC: A61M5/20 ,  A61M5/145 ,  A61M5/32

CPC classification number: A61M5/2033 ,  A61M5/1454 ,  A61M5/3204 ,  A61M5/326 ,  A61M2005/14256 ,  A61M2005/14506 ,  A61M2005/206 ,  A61M2005/31518 ,  A61M2005/3267

Abstract: A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.

公开(公告)号：US12208062B2

公开(公告)日：2025-01-28

申请号：US16072767

申请日：2017-02-06

Applicant: AMGEN INC.

Inventor： Hans Stenberg Knudsen ,  Matias Melander ,  Jakob Halkjaer Pedersen

IPC: A61J1/20 ,  A61M5/32 ,  A61M39/10

Abstract: The present invention relates to a pharmaceutical adaptor system. The pharmaceutical adaptor system comprises a syringe assembly having an axial extension and comprising a first end part and a second end part, the first end part having a male tubular projection, the syringe assembly comprising a syringe and a connecting element having a first mechanical connection part, a unit such as a needle, a vial, a catheter or an IV line, and an adaptor providing fluid communication between the syringe and the unit and having a second mechanical connection part configured to engage with the first mechanical connection part in an engagement direction, thereby in fully engaged position preventing further relative axial movement between the adaptor and the male tubular projection, wherein the adaptor comprises a sealing element configured to receive the male tubular projection and provide sealing between the male tubular projection and the adaptor. The present invention also relates to a pharmaceutical kit system comprising a pharmaceutical adaptor system according to the present invention.

公开(公告)号：US11590294B2

公开(公告)日：2023-02-28

申请号：US16609483

申请日：2018-06-01

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Hans Stenberg Knudsen ,  Rasmus Øhlenschlæger

IPC: A61M5/34 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32

Abstract: A syringe assembly for a drug delivery device. The syringe assembly includes a syringe barrel having a proximal end, a distal end, and a longitudinal axis. A needle assembly is operatively coupled to the syringe barrel and includes a needle hub and a needle attached to the needle hub. A flexible connection is disposed between the syringe barrel and the needle hub and forms a fluid pathway between the syringe barrel and the needle. The flexible connection enables the needle assembly to be moveable from a filling position, in which a longitudinal axis of the needle assembly is parallel to a longitudinal axis of the syringe barrel, to an assembled position, in which the longitudinal axis of the needle assembly is not parallel to the longitudinal axis of the syringe barrel.

公开(公告)号：US20190083359A1

公开(公告)日：2019-03-21

申请号：US16072767

申请日：2017-02-06

Applicant: AMGEN INC.

Inventor： Hans Stenberg Knudsen ,  Matias Melander ,  Jakob Halkjaer Pedersen

IPC: A61J1/20 ,  A61M39/10

Abstract: The present invention relates to a pharmaceutical adaptor system. The pharmaceutical adaptor system comprises a syringe assembly having an axial extension and comprising a first end part and a second end part, the first end part having a male tubular projection, the syringe assembly comprising a syringe and a connecting element having a first mechanical connection part, a unit such as a needle, a vial, a catheter or an IV line, and an adaptor providing fluid communication between the syringe and the unit and having a second mechanical connection part configured to engage with the first mechanical connection part in an engagement direction, thereby in fully engaged position preventing further relative axial movement between the adaptor and the male tubular projection, wherein the adaptor comprises a sealing element configured to receive the male tubular projection and provide sealing between the male tubular projection and the adaptor. The present invention also relates to a pharmaceutical kit system comprising a pharmaceutical adaptor system according to the present invention.