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公开(公告)号：US20250082858A1
公开(公告)日：2025-03-13
申请号：US18962542
申请日：2024-11-27
Applicant: AMGEN INC.
Inventor： Hans Stenberg Knudsen , Christian Plambech , Rasmus Øhlenschlæger , Jørgen Jørgensen
Abstract: A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.
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公开(公告)号：US12186536B2
公开(公告)日：2025-01-07
申请号：US17323830
申请日：2021-05-18
Applicant: AMGEN INC.
Inventor： Hans Stenberg Knudsen , Christian Plambech , Rasmus Øhlenschlæger , Jørgen Jørgensen
Abstract: A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.
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公开(公告)号：US11904143B2
公开(公告)日：2024-02-20
申请号：US16609466
申请日：2018-06-04
Applicant: AMGEN INC.
Inventor： Adam B. McCullough , Ronald Forster , Joseph Michael Iglesias , Matias Melander , Rasmus Øhlenschlaeger , Christian Plambech , Lars Stenholt , Bjarke Lykke Ludvig Svendsen
CPC classification number: A61M5/3145 , A61M5/20 , A61M5/31583 , A61M2005/3143
Abstract: An injector includes a housing having a syringe assembly and an actuating mechanism at least partially disposed within the housing. The syringe assembly includes a syringe barrel that stores a medicament to be injected into a user, a needle assembly, and a filter member disposed adjacent to the needle assembly. The actuating mechanism is operatively coupled to the syringe assembly and includes a torque spring that exerts a torque to urge the medicament through the filter member to be injected into the user. The actuating mechanism further includes a damper mechanism that exerts an opposing force to dampen the motion exerted by the torque spring.
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公开(公告)号：US12156991B2
公开(公告)日：2024-12-03
申请号：US16590636
申请日：2019-10-02
Applicant: AMGEN INC.
Inventor： Christian Plambech , Matias Melander
Abstract: Injection systems for drug delivery are disclosed. A system may include a container filled or fillable with a drug, a stopper movably disposed in the container, a plunger, an energy source outputting a force, a mechanical linkage operable to transmit the force output by the energy source to the plunger to cause the plunger to act on the stopper to expel the drug from the container, and a trigger member. The system may have pre-injection state where the trigger member inhibits actuation of the mechanical linkage, an injection state where the trigger member permits actuation of the mechanical linkage, and a post-injection state where the plunger is stationarily positioned in an end-of-dose position. The system may be designed to limit the number of components included in various force transmission loops present in the pre-injection, injection, and/or post-injection states.
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Patent Agency Ranking
公开(公告)号：US12102808B2
公开(公告)日：2024-10-01
申请号：US17036556
申请日：2020-09-29
Applicant: AMGEN INC.
Inventor： Christian Plambech , Matias Melander , Bjarke Lykke Ludvig Svendsen , Joshua Jay Dudman , Michael Sorensen , Margaux Frances Boyaval , Avon Kuo
CPC classification number: A61M5/3157 , A61M5/2033 , A61M5/3204 , A61M2205/581
Abstract: Drug delivery devices and related arrangements are disclosed. A drug delivery device may include a housing having an opening, a drug storage container including a delivery member with an insertion end configured to extend at least partially through the opening, and a plunger. A drive mechanism may be included for driving the plunger in a distal direction to expel a drug from the drug storage container through the delivery member upon activation. The drug delivery device may additionally include a guard moveably disposed adjacent to the opening and operably coupled to the drive mechanism for activation of the drive mechanism. A lock may be selectively engageable with the guard to limit movement of the guard in the proximal direction. An indicator may be coupled to the drive mechanism to generate an audible signal during drug delivery, and to cease generating the audible signal when drug delivery is complete.
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公开(公告)号：US20210346596A1
公开(公告)日：2021-11-11
申请号：US17277533
申请日：2019-10-15
Applicant: AMGEN INC.
Inventor： Jakob Halkjaer Pedersen , Matias Melander , Christian Plambech , Adam B. McCullough , Rasmus Ohlenschlager
Abstract: An approach for assembling a platform drug delivery device includes providing a set of base components and identifying, based on at least one desired characteristic of the platform drug delivery device, a rear sub-assembly for the drug delivery device from a group of rear sub-assemblies. The identified rear sub-assembly is selected, and a front sub-assembly is identified based on the at least one desired characteristic from a group of front sub-assemblies. The identified front-assembly is selected, and the drug delivery device is assembled using the set of base components, the rear sub-assembly, and the front sub-assembly.
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公开(公告)号：US11033684B2
公开(公告)日：2021-06-15
申请号：US15762939
申请日：2016-10-28
Applicant: AMGEN INC.
Inventor： Hans Stenberg Knudsen , Christian Plambech , Rasmus Øhlenschlæger , Jørgen Jørgensen
Abstract: A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.
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公开(公告)号：US12053617B2
公开(公告)日：2024-08-06
申请号：US16601824
申请日：2019-10-15
Applicant: AMGEN INC.
Inventor： Matias Melander , Jakob Halkjaer Pedersen , Christian Plambech , Adam B. McCullough , Julian Jazayeri
CPC classification number: A61M5/24 , A61M5/3129 , A61M5/3148 , A61M5/2033 , A61M2005/208 , A61M2005/2086 , A61M2005/3143 , A61M5/31585 , A61M2005/3267
Abstract: A drug delivery device includes a housing defining a shell having a proximal and a distal end, a needle assembly at least partially disposed within the housing at the proximal end, a drive assembly at least partially disposed within the housing, and a damper mechanism at least partially disposed within the housing adjacent to the distal end. The housing further defines a longitudinal axis extending between the proximal end and the distal end. The needle assembly includes a syringe barrel containing a medicament and a needle or a cannula. The drive assembly is operably coupled to the needle assembly to urge the medicament through the needle or cannula. The damper mechanism is operably coupled to the drive assembly and the housing. Upon activating the drive assembly, the damper mechanism dampens an effect thereof.
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