公开(公告)号：US20220168280A1

公开(公告)日：2022-06-02

申请号：US17589163

申请日：2022-01-31

Applicant: AMGEN INC.

Inventor： Brian Alan LANMAN ,  Victor J. CEE ,  Alexander J. PICKRELL ,  Anthony B. REED ,  Kevin C. YANG ,  David John KOPECKY ,  Hui-Ling WANG ,  Patricia LOPEZ ,  Kate ASHTON ,  Shon BOOKER ,  Christopher M. TEGLEY

IPC: A61K31/428 ,  A61K31/496 ,  A61K31/519 ,  A61P35/00 ,  A61K31/5025 ,  A61K31/502 ,  A61K31/517 ,  C07D275/04 ,  C07D471/08 ,  C07D403/04 ,  C07D401/04 ,  C07D513/04 ,  C07D487/04 ,  C07D417/04 ,  C07D239/80 ,  C07D487/10 ,  C07D471/04

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US20200171043A1

公开(公告)日：2020-06-04

申请号：US16783269

申请日：2020-02-06

Applicant: AMGEN INC.

Inventor： Paul E. HARRINGTON ,  Kate ASHTON ,  Sean P. BROWN ,  Matthew R. KALLER ,  Todd J. KOHN ,  Brian Alan LANMAN ,  Kexue LI ,  Yunxiao LI ,  Jonathan D. LOW ,  Ana Elena MINATTI ,  Alexander J. PICKRELL ,  Markian M. STEC ,  Joshua TAYGERLY

IPC: A61K31/553 ,  C07D498/08 ,  A61P35/00 ,  A61P35/02

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US20200069657A1

公开(公告)日：2020-03-05

申请号：US16675121

申请日：2019-11-05

Applicant: AMGEN INC.

Inventor： Brian Alan LANMAN ,  Victor J. CEE ,  Alexander J. PICKRELL ,  Anthony B. REED ,  Kevin C. YANG ,  David John KOPECKY ,  Hui-Ling WANG ,  Patricia LOPEZ ,  Kate ASHTON ,  Shon BOOKER ,  Christopher M. TEGLEY

IPC: A61K31/428 ,  A61K31/496 ,  A61K31/519 ,  A61P35/00 ,  A61K31/5025 ,  A61K31/502 ,  A61K31/517 ,  C07D275/04 ,  C07D471/08 ,  C07D403/04 ,  C07D401/04 ,  C07D513/04 ,  C07D487/04 ,  C07D417/04 ,  C07D239/80 ,  C07D487/10 ,  C07D471/04

Abstract: Provided herein are methods of treating cancer with KRAS G12C inhibitors and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US20180177767A1

公开(公告)日：2018-06-28

申请号：US15849905

申请日：2017-12-21

Applicant: AMGEN INC.

Inventor： Brian Alan LANMAN ,  Victor J. CEE ,  Alexander J. PICKRELL ,  Anthony B. REED ,  Kevin C. YANG ,  David John KOPECKY ,  Hui-Ling WANG ,  Patricia LOPEZ ,  Kate ASHTON ,  Shon BOOKER ,  Christopher M. TEGLEY

IPC: A61K31/428 ,  A61K31/496 ,  A61K31/519 ,  A61K31/517 ,  A61K31/5025 ,  A61K31/502 ,  A61P35/00

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US20250057817A1

公开(公告)日：2025-02-20

申请号：US18443925

申请日：2024-02-16

Applicant: AMGEN INC.

Inventor： Brian Alan LANMAN ,  Victor J. CEE ,  Alexander J. PICKRELL ,  Anthony B. REED ,  Kevin C. YANG ,  David John KOPECKY ,  Hui-Ling WANG ,  Patricia LOPEZ ,  Kate ASHTON ,  Shon BOOKER ,  Christopher M. TEGLEY

IPC: A61K31/428 ,  A61K31/496 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/517 ,  A61K31/519 ,  A61P35/00 ,  C07D239/80 ,  C07D275/04 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/10 ,  C07D513/04

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US20190381064A1

公开(公告)日：2019-12-19

申请号：US16547747

申请日：2019-08-22

Applicant: AMGEN INC.

Inventor： Paul E. HARRINGTON ,  Kate ASHTON ,  Sean P. BROWN ,  Matthew R. KALLER ,  Todd J. KOHN ,  Brian Alan LANMAN ,  Kexue LI ,  Yunxiao LI ,  Jonathan D. LOW ,  Ana Elena MINATTI ,  Alexander J. PICKRELL ,  Markian M. STEC ,  Joshua TAYGERLY

IPC: A61K31/553 ,  A61P35/02 ,  A61P35/00 ,  C07D498/08

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.