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公开(公告)号：US20250057817A1
公开(公告)日：2025-02-20
申请号：US18443925
申请日：2024-02-16
Applicant: AMGEN INC.
Inventor： Brian Alan LANMAN , Victor J. CEE , Alexander J. PICKRELL , Anthony B. REED , Kevin C. YANG , David John KOPECKY , Hui-Ling WANG , Patricia LOPEZ , Kate ASHTON , Shon BOOKER , Christopher M. TEGLEY
IPC: A61K31/428 , A61K31/496 , A61K31/502 , A61K31/5025 , A61K31/517 , A61K31/519 , A61P35/00 , C07D239/80 , C07D275/04 , C07D401/04 , C07D403/04 , C07D417/04 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/10 , C07D513/04
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20240092794A1
公开(公告)日：2024-03-21
申请号：US18502780
申请日：2023-11-06
Applicant: AMGEN INC.
Inventor： Shon BOOKER , Matthew Paul BOURBEAU , John R. BUTLER , Sanne Ormholt Schroder GLAD , Brian Alan LANMAN , Patricia LOPEZ , Francesco MANONI , Liping H. PETTUS , Ian SARVARY , Nuria A. TAMAYO , Mikkel VESTERGAARD , Nicholas Anthony WEIRES
IPC: C07D491/06 , A61P35/00 , C07D471/06 , C07D471/16 , C07D491/16
CPC classification number: C07D491/06 , A61P35/00 , C07D471/06 , C07D471/16 , C07D491/16
Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders. Compounds of Formula I have the following structure:
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公开(公告)号：US20190381064A1
公开(公告)日：2019-12-19
申请号：US16547747
申请日：2019-08-22
Applicant: AMGEN INC.
Inventor： Paul E. HARRINGTON , Kate ASHTON , Sean P. BROWN , Matthew R. KALLER , Todd J. KOHN , Brian Alan LANMAN , Kexue LI , Yunxiao LI , Jonathan D. LOW , Ana Elena MINATTI , Alexander J. PICKRELL , Markian M. STEC , Joshua TAYGERLY
IPC: A61K31/553 , A61P35/02 , A61P35/00 , C07D498/08
Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
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公开(公告)号：US20220213101A1
公开(公告)日：2022-07-07
申请号：US17692026
申请日：2022-03-10
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Shon BOOKER , Clifford GOODMAN , Anthony B. REED , Jonathan D. LOW , Hui-Ling WANG , Ning CHEN , Ana Elena MINATTI , Ryan WURZ , Victor J. CEE
IPC: C07D471/04 , A61P35/00 , A61K31/519
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20220194955A1
公开(公告)日：2022-06-23
申请号：US17552016
申请日：2021-12-15
Applicant: AMGEN INC.
Inventor： Shon BOOKER , Matthew Paul BOURBEAU , John R. BUTLER , Sanne Ormholt Schroder GLAD , Brian Alan LANMAN , Patricia LOPEZ , Francesco MANONI , Liping H. PETTUS , Ian SARVARY , Nuria A. TAMAYO , Mikkel VESTERGAARD , Nicholas Anthony WEIRES
IPC: C07D491/06 , C07D491/16 , C07D471/06 , C07D471/16 , A61P35/00
Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders. Compounds of Formula I have the following structure:
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Patent Agency Ranking
公开(公告)号：US20200171043A1
公开(公告)日：2020-06-04
申请号：US16783269
申请日：2020-02-06
Applicant: AMGEN INC.
Inventor： Paul E. HARRINGTON , Kate ASHTON , Sean P. BROWN , Matthew R. KALLER , Todd J. KOHN , Brian Alan LANMAN , Kexue LI , Yunxiao LI , Jonathan D. LOW , Ana Elena MINATTI , Alexander J. PICKRELL , Markian M. STEC , Joshua TAYGERLY
IPC: A61K31/553 , C07D498/08 , A61P35/00 , A61P35/02
Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
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公开(公告)号：US20200055845A1
公开(公告)日：2020-02-20
申请号：US16661907
申请日：2019-10-23
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , David John KOPECKY , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Nobuko NISHIMURA , Youngsook SHIN , Nuria A. TAMAYO , John Gordon ALLEN , Jennifer Rebecca ALLEN
IPC: C07D417/04 , C07D475/00 , C07D275/04 , A61K31/7068 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/519 , A61K31/517 , A61K31/454 , A61K31/55 , A61K31/416 , A61K31/496 , C07D403/04 , C07D237/34 , C07D401/14 , C07D239/80 , C07D401/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D513/04 , C07D417/12 , C07D487/08 , A61K38/07
Abstract: Provided herein are methods of using KRAS G12C inhibitors and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20200030324A1
公开(公告)日：2020-01-30
申请号：US16428163
申请日：2019-05-31
Applicant: Amgen Inc.
Inventor： Shon BOOKER , John Gordon ALLEN , Brian Alan LANMAN , Ryan Paul WURZ , Ning CHEN , Victor J. CEE , Patricia LOPEZ , Aaron C. SIEGMUND , Michael D. BARTBERGER
IPC: A61K31/497 , C07K16/28
Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20170107255A1
公开(公告)日：2017-04-20
申请号：US15317911
申请日：2015-06-10
Applicant: AMGEN INC.
Inventor： Jerry Ryan HOLDER , Gayathri SWAMINATH , Michael J. FROHN , Brian Alan LANMAN , Anthony B. REED , Leslie P. Miranda , John G. Allen , Alexander J. Pickrell , Aaron C. Siegmund , Lewis D. Pennington , Bryant Yang
CPC classification number: C07K7/08 , A61K38/00 , A61K38/10 , A61K47/542 , A61K47/60 , C07K14/47 , C07K2319/30
Abstract: The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
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公开(公告)号：US20240174660A1
公开(公告)日：2024-05-30
申请号：US18543498
申请日：2023-12-18
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , David John KOPECKY , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Nobuko NISHIMURA , Youngsook SHIN , Nuria A. TAMAYO , John Gordon ALLEN , Jennifer Rebecca ALLEN
IPC: C07D417/04 , A61K31/416 , A61K31/454 , A61K31/496 , A61K31/502 , A61K31/5025 , A61K31/517 , A61K31/519 , A61K31/55 , A61K31/7068 , A61K38/07 , A61P35/00 , C07D237/34 , C07D239/80 , C07D275/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D417/12 , C07D471/04 , C07D475/00 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04
CPC classification number: C07D417/04 , A61K31/416 , A61K31/454 , A61K31/496 , A61K31/502 , A61K31/5025 , A61K31/517 , A61K31/519 , A61K31/55 , A61K31/7068 , A61K38/07 , A61P35/00 , C07D237/34 , C07D239/80 , C07D275/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D417/12 , C07D471/04 , C07D475/00 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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