专利检索 ap:("AMGEN INC.") AND inv:"Anthony B. REED" 第 1 页

1.

发明申请
AMIDES AS PIM INHIBITORS 有权
标题翻译： AMIDES作为PIM抑制剂

公开(公告)号：US20150329538A1

公开(公告)日：2015-11-19

申请号：US14380918

申请日：2013-02-27

申请人： AMGEN INC.

发明人： Victor CEE , Frank CHAVEZ, JR. , Jian J. CHEN , Essa Hu HARRINGTON , Bradley HERBERICH , Claire L.M. JACKSON , Brian A. LANMAN , Thomas T. NGUYEN , Mark H. NORMAN , Liping H. PETTUS , Anthony B. REED , Adrian L. SMITH , Nuria A. TAMAYO , Andrew TASKER , Hui-Ling WANG , Bin WU , Ryan WURZ

IPC分类号： C07D471/04 , C07D401/04 , C07D487/04

CPC分类号： C07D471/04 , C07D401/04 , C07D487/04

摘要： The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

摘要翻译： 本发明涉及式（1）的含酰胺化合物及其盐。在一些实施方案中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。在另外的实施方案中，本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗Pim激酶相关病症和疾病，优选癌症中的用途。

2.

发明公开
INHIBITORS OF KRAS G12C AND METHODS OF USING THE SAME 审中-公开

公开(公告)号：US20240287068A1

公开(公告)日：2024-08-29

申请号：US18640641

申请日：2024-04-19

申请人： Amgen Inc.

发明人： Brian Alan LANMAN , Shon BOOKER , Clifford GOODMAN , Anthony B. REED , Jonathan D. LOW , Hui-Ling WANG , Ning CHEN , Ana Elena MINATTI , Ryan WURZ , Victor J. CEE

IPC分类号： C07D471/04 , A61K31/519 , A61K31/7068 , A61K38/07 , A61P35/00

CPC分类号： C07D471/04 , A61K31/519 , A61P35/00 , A61K31/7068 , A61K38/07 , A61K2300/00

摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

3.

发明申请
KRAS G12C INHIBITORS AND METHODS OF USING THE SAME 有权

公开(公告)号：US20220175782A1

公开(公告)日：2022-06-09

申请号：US17579359

申请日：2022-01-19

申请人： AMGEN INC.

发明人： John Gordon ALLEN , Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Jennifer Rebecca ALLEN , Margaret CHU-MOYER , Albert AMEGADZIE , Ning CHEN , Clifford GOODMAN , Jonathan D. LOW , Vu Van MA , Ana Elena MINATTI , Nobuko NISHIMURA , Alexander J. PICKRELL , Hui-Ling WANG , Youngsook SHIN , Aaron C. SIEGMUND , Kevin C. YANG , Nuria A. TAMAYO , Mary WALTON , Qiufen XUE

IPC分类号： A61K31/519 , A61K31/551 , A61K39/395 , A61P35/00

摘要： Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

4.

发明申请
KRAS G12C INHIBITORS AND METHODS OF USING THE SAME 有权

公开(公告)号：US20220168280A1

公开(公告)日：2022-06-02

申请号：US17589163

申请日：2022-01-31

申请人： AMGEN INC.

发明人： Brian Alan LANMAN , Victor J. CEE , Alexander J. PICKRELL , Anthony B. REED , Kevin C. YANG , David John KOPECKY , Hui-Ling WANG , Patricia LOPEZ , Kate ASHTON , Shon BOOKER , Christopher M. TEGLEY

IPC分类号： A61K31/428 , A61K31/496 , A61K31/519 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/517 , C07D275/04 , C07D471/08 , C07D403/04 , C07D401/04 , C07D513/04 , C07D487/04 , C07D417/04 , C07D239/80 , C07D487/10 , C07D471/04

摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

5.

发明申请
INHIBITORS OF KRAS G12C AND METHODS OF USING THE SAME 有权

公开(公告)号：US20220213101A1

公开(公告)日：2022-07-07

申请号：US17692026

申请日：2022-03-10

申请人： Amgen Inc.

发明人： Brian Alan LANMAN , Shon BOOKER , Clifford GOODMAN , Anthony B. REED , Jonathan D. LOW , Hui-Ling WANG , Ning CHEN , Ana Elena MINATTI , Ryan WURZ , Victor J. CEE

IPC分类号： C07D471/04 , A61P35/00 , A61K31/519

摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

6.

发明申请
KRAS G12C INHIBITORS AND METHODS OF USING THE SAME 审中-公开

公开(公告)号：US20200055845A1

公开(公告)日：2020-02-20

申请号：US16661907

申请日：2019-10-23

申请人： Amgen Inc.

发明人： Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , David John KOPECKY , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Nobuko NISHIMURA , Youngsook SHIN , Nuria A. TAMAYO , John Gordon ALLEN , Jennifer Rebecca ALLEN

IPC分类号： C07D417/04 , C07D475/00 , C07D275/04 , A61K31/7068 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/519 , A61K31/517 , A61K31/454 , A61K31/55 , A61K31/416 , A61K31/496 , C07D403/04 , C07D237/34 , C07D401/14 , C07D239/80 , C07D401/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D513/04 , C07D417/12 , C07D487/08 , A61K38/07

摘要： Provided herein are methods of using KRAS G12C inhibitors and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

7.

发明申请
APELIN POLYPEPTIDES 审中-公开

公开(公告)号：US20170107255A1

公开(公告)日：2017-04-20

申请号：US15317911

申请日：2015-06-10

申请人： AMGEN INC.

发明人： Jerry Ryan HOLDER , Gayathri SWAMINATH , Michael J. FROHN , Brian Alan LANMAN , Anthony B. REED , Leslie P. Miranda , John G. Allen , Alexander J. Pickrell , Aaron C. Siegmund , Lewis D. Pennington , Bryant Yang

IPC分类号： C07K7/08 , A61K38/10

CPC分类号： C07K7/08 , A61K38/00 , A61K38/10 , A61K47/542 , A61K47/60 , C07K14/47 , C07K2319/30

摘要： The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.