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公开(公告)号：US20220168280A1
公开(公告)日：2022-06-02
申请号：US17589163
申请日：2022-01-31
申请人： AMGEN INC.
发明人： Brian Alan LANMAN , Victor J. CEE , Alexander J. PICKRELL , Anthony B. REED , Kevin C. YANG , David John KOPECKY , Hui-Ling WANG , Patricia LOPEZ , Kate ASHTON , Shon BOOKER , Christopher M. TEGLEY
IPC分类号： A61K31/428 , A61K31/496 , A61K31/519 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/517 , C07D275/04 , C07D471/08 , C07D403/04 , C07D401/04 , C07D513/04 , C07D487/04 , C07D417/04 , C07D239/80 , C07D487/10 , C07D471/04
摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20190381064A1
公开(公告)日：2019-12-19
申请号：US16547747
申请日：2019-08-22
申请人： AMGEN INC.
发明人： Paul E. HARRINGTON , Kate ASHTON , Sean P. BROWN , Matthew R. KALLER , Todd J. KOHN , Brian Alan LANMAN , Kexue LI , Yunxiao LI , Jonathan D. LOW , Ana Elena MINATTI , Alexander J. PICKRELL , Markian M. STEC , Joshua TAYGERLY
IPC分类号： A61K31/553 , A61P35/02 , A61P35/00 , C07D498/08
摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
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公开(公告)号：US20200171043A1
公开(公告)日：2020-06-04
申请号：US16783269
申请日：2020-02-06
申请人： AMGEN INC.
发明人： Paul E. HARRINGTON , Kate ASHTON , Sean P. BROWN , Matthew R. KALLER , Todd J. KOHN , Brian Alan LANMAN , Kexue LI , Yunxiao LI , Jonathan D. LOW , Ana Elena MINATTI , Alexander J. PICKRELL , Markian M. STEC , Joshua TAYGERLY
IPC分类号： A61K31/553 , C07D498/08 , A61P35/00 , A61P35/02
摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
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公开(公告)号：US20200069657A1
公开(公告)日：2020-03-05
申请号：US16675121
申请日：2019-11-05
申请人： AMGEN INC.
发明人： Brian Alan LANMAN , Victor J. CEE , Alexander J. PICKRELL , Anthony B. REED , Kevin C. YANG , David John KOPECKY , Hui-Ling WANG , Patricia LOPEZ , Kate ASHTON , Shon BOOKER , Christopher M. TEGLEY
IPC分类号： A61K31/428 , A61K31/496 , A61K31/519 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/517 , C07D275/04 , C07D471/08 , C07D403/04 , C07D401/04 , C07D513/04 , C07D487/04 , C07D417/04 , C07D239/80 , C07D487/10 , C07D471/04
摘要： Provided herein are methods of treating cancer with KRAS G12C inhibitors and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20180177767A1
公开(公告)日：2018-06-28
申请号：US15849905
申请日：2017-12-21
申请人： AMGEN INC.
发明人： Brian Alan LANMAN , Victor J. CEE , Alexander J. PICKRELL , Anthony B. REED , Kevin C. YANG , David John KOPECKY , Hui-Ling WANG , Patricia LOPEZ , Kate ASHTON , Shon BOOKER , Christopher M. TEGLEY
IPC分类号： A61K31/428 , A61K31/496 , A61K31/519 , A61K31/517 , A61K31/5025 , A61K31/502 , A61P35/00
摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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