公开(公告)号：US10829551B2

公开(公告)日：2020-11-10

申请号：US15150627

申请日：2016-05-10

Applicant: AMGEN INC.

Inventor： Jian Wu ,  Nicole Sabo ,  Michael De La Cruz ,  Gregory Flynn

IPC: A61K39/395 ,  C07K16/24 ,  C07K16/00 ,  C12P21/00 ,  C12N5/00 ,  A61K39/00

Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.

公开(公告)号：US09359435B2

公开(公告)日：2016-06-07

申请号：US13741280

申请日：2013-01-14

Applicant: AMGEN INC.

Inventor： Jian Wu ,  Nicole Le ,  Michael De La Cruz ,  Gregory Flynn

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/24 ,  C12P21/00

CPC classification number: C07K16/244 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C12N5/0037 ,  C12N2500/02 ,  C12N2500/12 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2500/60 ,  C12N2500/74 ,  C12N2500/76 ,  C12P21/005

Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.