-
公开(公告)号：US11660391B2
公开(公告)日：2023-05-30
申请号：US16745693
申请日：2020-01-17
Applicant: AMGEN INC.
Inventor： Daniel Eduardo Groszmann , Scott Robert Gibson
CPC classification number: A61M5/16836 , A61M5/14212 , A61M5/2033 , A61M5/2459 , A61M5/3157 , A61M2205/18 , A61M2205/3344
Abstract: Systems and methods for injecting a drug and detecting tissue induced back pressure are disclosed. A drug delivery system may include a reservoir filled or fillable with a drug, an administration member connected or connectable in fluid communication with the reservoir, a drive assembly, and a pressure sensor. The administration member may be configured for insertion into and subsequently retraction from a patient. The drive assembly may be configured to urge the drug from the reservoir to deliver a dose of the drug to the patient via the administration member. The pressure sensor may be configured to detect tissue back pressure during use of the drug delivery system, including after dose completion and prior to retraction of the administration member. The drug delivery system may be controlled in a manner that accounts for the tissue back pressure measurement.
-
公开(公告)号：US11213620B2
公开(公告)日：2022-01-04
申请号：US17278618
申请日：2019-10-07
Applicant: AMGEN INC.
Inventor： Ali Nekouzadeh , Carl Conrath , Scott Robert Gibson , Basel Hasan Taha
Abstract: Methods, devices, and components are provided to reduce tissue resistive pressure during a subcutaneous drug delivery operation by increasing the size of the injection cavity by partially retracting the drug delivery member after inserting the drug delivery member to a subcutaneous position. The drug delivery devices described herein include a magnetic actuator operably coupled to a primary container assembly including a drug delivery member. Power can be selectively provided to the magnetic actuator by a controller to retract the drug delivery member a predetermined distance to relieve pressure in an injection cavity in a patient. A force sensor can provide the controller with a drug delivery member insertion force. The controller can then estimate a tissue resistive pressure based on the drug delivery member insertion force and determine the predetermined distance for the drug delivery member retraction based on the tissue resistive pressure.
-
公开(公告)号：US20210308376A1
公开(公告)日：2021-10-07
申请号：US17278618
申请日：2019-10-07
Applicant: AMGEN INC.
Inventor： Ali Nekouzadeh , Carl Conrath , Scott Robert Gibson , Basel Hasan Taha
Abstract: Methods, devices, and components are provided to reduce tissue resistive pressure during a subcutaneous drug delivery operation by increasing the size of the injection cavity by partially retracting the drug delivery member after inserting the drug delivery member to a subcutaneous position. The drug delivery devices described herein include a magnetic actuator operably coupled to a primary container assembly including a drug delivery member. Power can be selectively provided to the magnetic actuator by a controller to retract the drug delivery member a predetermined distance to relieve pressure in an injection cavity in a patient. A force sensor can provide the controller with a drug delivery member insertion force. The controller can then estimate a tissue resistive pressure based on the drug delivery member insertion force and determine the predetermined distance for the drug delivery member retraction based on the tissue resistive pressure.
-
公开(公告)号：US20200289740A1
公开(公告)日：2020-09-17
申请号：US15775650
申请日：2016-12-14
Applicant: AMGEN INC.
Inventor： Ferry Tamtoro , Huaying Yang , Scott Robert Gibson , Donald Busby , Peter V. Shultz , Basel Hasan Taha , Adam B. McCullough
Abstract: A drug delivery system includes a storage container defining one or more storage compartments and having at least one container sensor coupled thereto, a container condition change mechanism coupled to the storage container for imparting a change on one or more conditions of the one or more storage compartments, at least one drug delivery device adapted to deliver a drug to a user and adapted to be at least partially disposed within one or more of the one or more storage compartments, at least one delivery device sensor, a delivery device condition change mechanism coupled to the drug delivery device, and a controller coupled to the storage container. The storage container may be adapted to hold a number of drug delivery devices within a number of sealable storage compartments. The container sensor is adapted to sense a condition of the storage container, and the delivery device sensor is adapted to sense a condition of the at least one drug delivery device. The controller is adapted to instruct the container condition change mechanism and/or the delivery device change mechanism to impart a change on at least one condition of the storage container and/or the drug delivery device.
-
公开(公告)号：US20200238005A1
公开(公告)日：2020-07-30
申请号：US16725069
申请日：2019-12-23
Applicant: AMGEN INC.
Inventor： Daniel Eduardo Groszmann , Scott Robert Gibson
Abstract: Systems and methods for drug delivery with pressure sensitive control are disclosed. A drug delivery system may include a reservoir filled or fillable with a drug, a drug delivery device coupled to the reservoir to deliver the drug from the reservoir to a patient, a pressure sensor, an output device, and a controller. The controller may be configured to determine if the drug delivery device has completed delivering a dose of the drug to the patient, and if delivery of the dose of the drug is complete, to measure tissue back pressure using the pressure sensor. Subsequently, the controller may be configured to determine if the tissue back pressure is below a first predetermined value, and if so, control the output device at least once and/or control a mechanism to retract an administration member from the patient.
-
Patent Agency Ranking
公开(公告)号：US11207460B2
公开(公告)日：2021-12-28
申请号：US15775650
申请日：2016-12-14
Applicant: AMGEN INC.
Inventor： Ferry Tamtoro , Huaying Yang , Scott Robert Gibson , Donald Busby , Peter V. Shultz , Basel Hasan Taha , Adam B. McCullough
Abstract: A drug delivery system includes a storage container defining one or more storage compartments and having at least one container sensor coupled thereto, a container condition change mechanism coupled to the storage container for imparting a change on one or more conditions of the one or more storage compartments, at least one drug delivery device adapted to deliver a drug to a user and adapted to be at least partially disposed within one or more of the one or more storage compartments, at least one delivery device sensor, a delivery device condition change mechanism coupled to the drug delivery device, and a controller coupled to the storage container. The storage container may be adapted to hold a number of drug delivery devices within a number of sealable storage compartments. The container sensor is adapted to sense a condition of the storage container, and the delivery device sensor is adapted to sense a condition of the at least one drug delivery device. The controller is adapted to instruct the container condition change mechanism and/or the delivery device change mechanism to impart a change on at least one condition of the storage container and/or the drug delivery device.
-
公开(公告)号：US20210228811A1
公开(公告)日：2021-07-29
申请号：US17264157
申请日：2019-09-17
Applicant: AMGEN INC.
Inventor： Sudeshna Dutta Ray , Scott Robert Gibson , Daniel Eduardo Groszmann , Mehran Mojarrad , Andrew James Carlson , Lee Gordon Macklem , Mikhail Tikh
Abstract: Drug delivery devices are described that include an escapement activation assembly. The escapement activation assembly includes a slide having a plurality of pallet engagement portions and a switch engagement portion and a pallet having a plurality of slide engagement portions. A drive is coupled to the pallet to cause the pallet to move relative to the slide to move the plurality of slide engagement portions into and out of engagement with the plurality of pallet engagement portions to allow the slide to move along a path within the drug delivery device. Movement of the slide can cause the switch engagement portion to move out of engagement with an activation trigger of a mechanism of the drug delivery device.
-
公开(公告)号：US20200261648A1
公开(公告)日：2020-08-20
申请号：US16761521
申请日：2018-10-04
Applicant: AMGEN INC.
Inventor： Daniel Eduardo Groszmann , Scott Robert Gibson
IPC: A61M5/172
Abstract: A drug delivery device is provided that includes an on-board controller to determine when proper placement on the patient's body has occurred as well as an amount of drug delivered to the patient. The controller can also be used to determine if and when the proper placement has been disturbed during drug delivery and/or if less than a full dose of the drug has been dispensed.
-
公开(公告)号：US20180318526A1
公开(公告)日：2018-11-08
申请号：US15775630
申请日：2016-12-09
Applicant: AMGEN INC.
Inventor： Huaying Yang , Desheng Yin , Ferry Tamtoro , Scott Robert Gibson , Keith P. Kogler , Michael Friedman , Neal Johnston , Adam B. McCullough
IPC: A61M5/50 , A61M5/24 , A61M5/32 , A61M5/20 , A61K38/19 , C07K16/40 , C07K14/705 , A61K38/17 , C07K16/28
CPC classification number: A61M5/5086 , A61K38/1793 , A61K38/193 , A61M5/2033 , A61M5/2466 , A61M5/3204 , A61M5/326 , A61M5/3286 , A61M2005/2086 , A61M2005/3104 , A61M2205/13 , A61M2205/14 , A61M2205/3368 , A61M2205/3553 , A61M2205/3561 , A61M2205/3584 , A61M2205/36 , A61M2205/50 , A61M2205/581 , A61M2205/609 , A61M2205/8206 , A61M2205/8212 , C07K14/70578 , C07K16/2803 , C07K16/40 , C07K2317/31 , C07K2319/30 , G06F19/00 , G06F19/3468
Abstract: A drug delivery device includes a housing defining a shell, a drug delivery assembly at least partially disposed within the housing, a cap defining an opening and being adapted to at least partially cover an end of the housing, at least one electronic component, a power source which powers the electronic component, and a switch assembly. The drug delivery assembly comprises a guard which engages an inner surface of the housing and is movable between a first, a second, and a third position relative to the housing and are adapted to restrict external contact with a cannula. The switch assembly causes the power source to provide power to the electronic component when the cap is removed from the housing, restrict the power source from providing power when the cap is coupled to the housing and the guard is in the first position, and cause the power source to provide power when the cap is coupled to the housing and the guard is in the third position.
-
公开(公告)号：US11583633B2
公开(公告)日：2023-02-21
申请号：US15944709
申请日：2018-04-03
Applicant: AMGEN INC.
Inventor： Scott Robert Gibson , Adam B. McCullough
Abstract: Systems and methods for delayed delivery of a drug are disclosed. A drug delivery system may include a delivery member for insertion into a patient and a reservoir configured to receive a volume of a drug. An energy source may be activatable by the patient to actuate the reservoir to deliver the drug to the patient as a single bolus. A lockout system may be configured to have a locked state, wherein the lockout system prevents movement of the delivery member and/or activation of the energy source, and an unlocked state, wherein the lockout system permits movement of the delivery member and/or activation of the energy source. The lockout system may be configured to automatically change from the locked state to the unlocked state after a preselected time period has elapsed. An output element may generate a detectable output after the preselected time period has elapsed for notifying the patient.
-
-
-
-
-
-
-
-
-
Search Results
29
records
(took 0.016 seconds)
