公开(公告)号：US11957669B2

公开(公告)日：2024-04-16

申请号：US16638038

申请日：2018-08-10

Applicant: AMOREPACIFIC CORPORATION

Inventor： Joon Ho Choi ,  Won Kyung Cho ,  Kwang-Hyun Shin ,  Byoung Young Woo ,  Ki-Wha Lee ,  Min-Soo Kim ,  Jong Hwa Roh ,  Mi Young Park ,  Young-Ho Park ,  Eun Sil Park ,  Jae Hong Park

IPC: A61K31/44 ,  A61K9/00 ,  A61K47/38

CPC classification number: A61K31/44 ,  A61K9/0014 ,  A61K47/38

Abstract: One aspect of the present disclosure is a pharmaceutical composition which includes (R)—N-[1-(3,5-difluoro-4-methansulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide as a first component and a cellulosic polymer as a second component, wherein the composition of one aspect of the present disclosure has a formulation characteristic in which crystal formation is delayed for a long time.

公开(公告)号：US10479763B2

公开(公告)日：2019-11-19

申请号：US15325349

申请日：2016-02-15

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young Woo ,  Ki-Wha Lee ,  Kwang-Hyun Shin ,  Miyoung Park ,  Kyoungmi Jung ,  Joonho Choi ,  Gyeyoung Choi ,  Wonkyung Cho ,  Young-Ho Park

IPC: C07C303/42 ,  C07C303/36 ,  C07C311/08 ,  C07C303/44 ,  C07D213/56 ,  C07B57/00 ,  C07C63/06

Abstract: The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral auxiliary is an O,O′-diacyltartaric acid derivative, more specifically, a 2,3-dibenzoyl-tartaric acid or O,O′-di-p-toluoyl tartaric acid, the salt-forming auxiliary compound is mandelic acid or camphorsulfonic acid, and an optical isomer having a high level of optical purity can be obtained by using the method. Therefore, according to one aspect of the present invention, the method can be useful in pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity.