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公开(公告)号:US10816541B2
公开(公告)日:2020-10-27
申请号:US15542263
申请日:2016-02-26
Applicant: AMOREPACIFIC CORPORATION
Inventor: Chang Seok Lee , Heung Soo Baek , Yung Hyup Joo , Jeong Hwan Kim , Hong-Ju Shin , Mi Young Park , Song Seok Shin
IPC: G01N33/50
Abstract: In one aspect of the present specification, provided is a method for predicting a side effect of a whitening ingredient, the method comprising measuring at least one of i) the increase in toxicity according to long-term use of a whitening ingredient, ii) the difference between a concentration having whitening effect and a concentration having cell toxicity, and iii) the increase in sensitivity to the whitening ingredient according to ultraviolet pretreatment. In addition, the method has an effect of effectively predicting whether a side effect will occur if the whitening ingredient is used for a long time.
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公开(公告)号:US11957669B2
公开(公告)日:2024-04-16
申请号:US16638038
申请日:2018-08-10
Applicant: AMOREPACIFIC CORPORATION
Inventor: Joon Ho Choi , Won Kyung Cho , Kwang-Hyun Shin , Byoung Young Woo , Ki-Wha Lee , Min-Soo Kim , Jong Hwa Roh , Mi Young Park , Young-Ho Park , Eun Sil Park , Jae Hong Park
CPC classification number: A61K31/44 , A61K9/0014 , A61K47/38
Abstract: One aspect of the present disclosure is a pharmaceutical composition which includes (R)—N-[1-(3,5-difluoro-4-methansulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide as a first component and a cellulosic polymer as a second component, wherein the composition of one aspect of the present disclosure has a formulation characteristic in which crystal formation is delayed for a long time.
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