公开(公告)号：US20230225984A1

公开(公告)日：2023-07-20

申请号：US17927780

申请日：2021-05-27

Applicant: ATTGENO AB

Inventor： Per Håkan Agvald ,  Kristofer Bo Ingemar Nilsson ,  Leif Christofer Adding

IPC: A61K31/045 ,  C07C215/06 ,  A61P31/12 ,  A61P31/04 ,  A61P33/00

CPC classification number: A61K31/045 ,  C07C215/06 ,  A61P31/12 ,  A61P31/04 ,  A61P33/00

Abstract: The present invention relates to the use of mono- and bis nitrosylated propanediols, and compositions and formulations comprising the same, in methods for the treatment of a microbial infection.

公开(公告)号：US20230201132A1

公开(公告)日：2023-06-29

申请号：US17927774

申请日：2021-05-27

Applicant: ATTGENO AB

Inventor： Per Håkan Agvald ,  Kristofer Bo Ingemar Nilsson ,  Leif Christofer Adding ,  Anna Karolina Maria Stene HURTSÉN

IPC: A61K31/047 ,  A61P9/06 ,  A61M15/06 ,  A61M15/00 ,  A61M11/00

CPC classification number: A61K31/047 ,  A61P9/06 ,  A61M15/06 ,  A61M15/0021 ,  A61M15/0028 ,  A61M11/006 ,  A61M2205/50

Abstract: The present invention relates to methods of treating a condition wherein NO has a beneficial effect, wherein such treatment comprises administering certain mono- and/or bis nitrosylated propanediols, including compositions and formulations thereof, wherein administration of said compounds, compositions or formulations is indirect to the pulmonary circulation and/or the systemic circulation of a patient in need thereof.

公开(公告)号：US20220002223A1

公开(公告)日：2022-01-06

申请号：US17296593

申请日：2019-11-27

Applicant: ATTGENO AB

Inventor： Per Håkan Agvald ,  Leif Christofer Adding ,  Kristofer Bo Ingemar Nilsson ,  Anna Lena Elisabeth Minidis ,  Johan Salman Malmberg ,  Alexander Bogdan Emil Minidis

IPC: C07C201/04

Abstract: Disclosed is a process for the synthesis of mono- and bis-nitrosylated propanediols, as well as compositions and pharmaceutical formulations that includes the compounds. The process proceeds by reacting a corresponding propanediol that is not nitrosylated with a source of nitrite, optionally in the presence of a suitable acid. When the source of nitrite is an organic nitrite, reacting step is performed in a suitable organic solvent, and when the source of nitrite is an inorganic nitrite, the reacting step is performed in a bi-phasic solvent mixture comprising an aqueous phase and a non-aqueous phase. Also disclosed are methods of treating a condition wherein administration of nitric oxide (NO) has a beneficial effect by administering said compounds, compositions or formulations.